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Acidosis leads to neurological disorders through overexciting cortical pyramidal neurons

► Extracellular low pH impairs cortical pyramidal neurons in response to excitatory synaptic inputs. ► Extracellular low pH impairs the abilities of encoding spikes at these pyramidal neurons. ► Neuronal impairment is associated with the decreases of spike refractory periods and thresholds. ► Extrac... Full description

Journal Title: Biochemical and Biophysical Research Communications 18 November 2011, Vol.415(2), pp.224-228
Main Author: Zhao, Hong
Other Authors: Cai, Yan , Yang, Zichao , He, Dandan , Shen, Baozhong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2011.08.008
Link: https://www.sciencedirect.com/science/article/pii/S0006291X11013933
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recordid: elsevier_sdoi_10_1016_j_bbrc_2011_08_008
title: Acidosis leads to neurological disorders through overexciting cortical pyramidal neurons
format: Article
creator:
  • Zhao, Hong
  • Cai, Yan
  • Yang, Zichao
  • He, Dandan
  • Shen, Baozhong
subjects:
  • Acidosis
  • Pyramidal Neuron
  • Action Potential
  • Synaptic Transmission
  • Sodium Channel
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: Biochemical and Biophysical Research Communications, 18 November 2011, Vol.415(2), pp.224-228
description: ► Extracellular low pH impairs cortical pyramidal neurons in response to excitatory synaptic inputs. ► Extracellular low pH impairs the abilities of encoding spikes at these pyramidal neurons. ► Neuronal impairment is associated with the decreases of spike refractory periods and thresholds. ► Extracellular low pH impairs GABAergic synaptic transmission at these pyramidal neurons. The patients suffering from acidosis usually sign psychological deficits. The cerebral dysfunction is reportedly caused by an acid-induced functional impairment of GABAergic neurons; however, the role of pyramidal neurons in this process remains unclear. By using electrophysiological method and changing extracellular pH, we investigated the influence of acidic environment on pyramidal neurons in the cortical slices, such as their ability of firing spikes and response to synaptic inputs. A low pH of artificial cerebral spinal fluid elevates the responses of pyramidal neurons to excitatory...
language: eng
source:
identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2011.08.008
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
  • 1090-2104
  • 10902104
url: Link


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titleAcidosis leads to neurological disorders through overexciting cortical pyramidal neurons
creatorZhao, Hong ; Cai, Yan ; Yang, Zichao ; He, Dandan ; Shen, Baozhong
ispartofBiochemical and Biophysical Research Communications, 18 November 2011, Vol.415(2), pp.224-228
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subjectAcidosis ; Pyramidal Neuron ; Action Potential ; Synaptic Transmission ; Sodium Channel ; Biology ; Chemistry ; Anatomy & Physiology
description► Extracellular low pH impairs cortical pyramidal neurons in response to excitatory synaptic inputs. ► Extracellular low pH impairs the abilities of encoding spikes at these pyramidal neurons. ► Neuronal impairment is associated with the decreases of spike refractory periods and thresholds. ► Extracellular low pH impairs GABAergic synaptic transmission at these pyramidal neurons. The patients suffering from acidosis usually sign psychological deficits. The cerebral dysfunction is reportedly caused by an acid-induced functional impairment of GABAergic neurons; however, the role of pyramidal neurons in this process remains unclear. By using electrophysiological method and changing extracellular pH, we investigated the influence of acidic environment on pyramidal neurons in the cortical slices, such as their ability of firing spikes and response to synaptic inputs. A low pH of artificial cerebral spinal fluid elevates the responses of pyramidal neurons to excitatory...
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► Extracellular low pH impairs cortical pyramidal neurons in response to excitatory synaptic inputs. ► Extracellular low pH impairs the abilities of encoding spikes at these pyramidal neurons. ► Neuronal impairment is associated with the decreases of spike refractory periods and thresholds. ► Extracellular low pH impairs GABAergic synaptic transmission at these pyramidal neurons.

The patients suffering from acidosis usually sign psychological deficits. The cerebral dysfunction is reportedly caused by an acid-induced functional impairment of GABAergic neurons; however, the role of pyramidal neurons in this process remains unclear. By using electrophysiological method and changing extracellular pH, we investigated the influence of acidic environment on pyramidal neurons in the cortical slices, such as their ability of firing spikes and response to synaptic inputs. A low pH of artificial cerebral spinal fluid elevates the responses of pyramidal neurons to excitatory...

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► Extracellular low pH impairs cortical pyramidal neurons in response to excitatory synaptic inputs. ► Extracellular low pH impairs the abilities of encoding spikes at these pyramidal neurons. ► Neuronal impairment is associated with the decreases of spike refractory periods and thresholds. ► Extracellular low pH impairs GABAergic synaptic transmission at these pyramidal neurons.

The patients suffering from acidosis usually sign psychological deficits. The cerebral dysfunction is reportedly caused by an acid-induced functional impairment of GABAergic neurons; however, the role of pyramidal neurons in this process remains unclear. By using electrophysiological method and changing extracellular pH, we investigated the influence of acidic environment on pyramidal neurons in the cortical slices, such as their ability of firing spikes and response to synaptic inputs. A low pH of artificial cerebral spinal fluid elevates the responses of pyramidal neurons to excitatory...

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