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Genetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease

rs2869967 and rs3821104 are associated with COPD in Chinese Han population. ► No statistically significant association between rs2568494 and COPD. ► The discovery of variants may contribute to the development of new therapeutic approaches to COPD. Recently, variants (rs2568494, rs2869967 and rs38211... Full description

Journal Title: Biochemical and Biophysical Research Communications 18 November 2011, Vol.415(2), pp.284-287
Main Author: Guo, Yi
Other Authors: Lin, Hua , Gao, Kai , Xu, Hongbo , Deng, Xiong , Zhang, Qiang , Luo, Ziqiang , Sun, Shenghua , Deng, Hao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2011.10.042
Link: https://www.sciencedirect.com/science/article/pii/S0006291X11018390
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recordid: elsevier_sdoi_10_1016_j_bbrc_2011_10_042
title: Genetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease
format: Article
creator:
  • Guo, Yi
  • Lin, Hua
  • Gao, Kai
  • Xu, Hongbo
  • Deng, Xiong
  • Zhang, Qiang
  • Luo, Ziqiang
  • Sun, Shenghua
  • Deng, Hao
subjects:
  • Chronic Obstructive Pulmonary Disease
  • Genetics
  • Ireb2
  • Fam13a
  • Xrcc5
  • Association
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: Biochemical and Biophysical Research Communications, 18 November 2011, Vol.415(2), pp.284-287
description: rs2869967 and rs3821104 are associated with COPD in Chinese Han population. ► No statistically significant association between rs2568494 and COPD. ► The discovery of variants may contribute to the development of new therapeutic approaches to COPD. Recently, variants (rs2568494, rs2869967 and rs3821104) in the , and genes were found to be associated with chronic obstructive pulmonary disease (COPD) in non-Asian populations by genome-wide association study (GWAS) analysis. To evaluate whether variants in these genes are related to COPD in Chinese Han population, we investigated COPD patients of Chinese Han ethnicity from Mainland China. Significant differences in genotypic distributions ( = 6.319, = 0.042 for rs2869967; = 6.062, = 0.048 for rs3821104) and allele distributions ( = 4.014, = 0.045 for rs2869967; = 5.607, = 0.018 for rs3821104) were observed between patients and control subjects for variants rs2869967 and rs3821104, whereas no statistically significant associations for genotypic and allelic distribution between rs2568494 and COPD phenotype ( > 0.05) were identified. Our results support that rs2869967 and rs3821104 are associated with COPD in Chinese Han population.
language: eng
source:
identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2011.10.042
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
  • 1090-2104
  • 10902104
url: Link


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titleGenetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease
creatorGuo, Yi ; Lin, Hua ; Gao, Kai ; Xu, Hongbo ; Deng, Xiong ; Zhang, Qiang ; Luo, Ziqiang ; Sun, Shenghua ; Deng, Hao
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subjectChronic Obstructive Pulmonary Disease ; Genetics ; Ireb2 ; Fam13a ; Xrcc5 ; Association ; Biology ; Chemistry ; Anatomy & Physiology
descriptionrs2869967 and rs3821104 are associated with COPD in Chinese Han population. ► No statistically significant association between rs2568494 and COPD. ► The discovery of variants may contribute to the development of new therapeutic approaches to COPD. Recently, variants (rs2568494, rs2869967 and rs3821104) in the , and genes were found to be associated with chronic obstructive pulmonary disease (COPD) in non-Asian populations by genome-wide association study (GWAS) analysis. To evaluate whether variants in these genes are related to COPD in Chinese Han population, we investigated COPD patients of Chinese Han ethnicity from Mainland China. Significant differences in genotypic distributions ( = 6.319, = 0.042 for rs2869967; = 6.062, = 0.048 for rs3821104) and allele distributions ( = 4.014, = 0.045 for rs2869967; = 5.607, = 0.018 for rs3821104) were observed between patients and control subjects for variants rs2869967 and rs3821104, whereas no statistically significant associations for genotypic and allelic distribution between rs2568494 and COPD phenotype ( > 0.05) were identified. Our results support that rs2869967 and rs3821104 are associated with COPD in Chinese Han population.
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