schliessen

Filtern

 

Bibliotheken

Cyclophilin A inhibits rotavirus replication by facilitating host IFN-I production

► CYPA inhibited RV replication in host cells. ► CYPA regulated IFN-β production in RV-infected MA104 cells. ► IFN-β produced by host cells inhibited RV infection. ► The effect of CYPA on IFN-β production in RV infection depended on JNK activation. Rotavirus (RV) infection causes serious dehydrating... Full description

Journal Title: Biochemical and Biophysical Research Communications 15 June 2012, Vol.422(4), pp.664-669
Main Author: He, Haiyang
Other Authors: Zhou, Daijun , Fan, Weiping , Fu, Xiaolan , Zhang, Ji , Shen, Zigang , Li, Jian , Li, Jintao , Wu, Yuzhang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.05.050
Link: https://www.sciencedirect.com/science/article/pii/S0006291X12009278
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_bbrc_2012_05_050
title: Cyclophilin A inhibits rotavirus replication by facilitating host IFN-I production
format: Article
creator:
  • He, Haiyang
  • Zhou, Daijun
  • Fan, Weiping
  • Fu, Xiaolan
  • Zhang, Ji
  • Shen, Zigang
  • Li, Jian
  • Li, Jintao
  • Wu, Yuzhang
subjects:
  • Cyclophilin A
  • IFN-I
  • Jnk Signaling Pathway
  • Rotavirus
  • Viral Production
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: Biochemical and Biophysical Research Communications, 15 June 2012, Vol.422(4), pp.664-669
description: ► CYPA inhibited RV replication in host cells. ► CYPA regulated IFN-β production in RV-infected MA104 cells. ► IFN-β produced by host cells inhibited RV infection. ► The effect of CYPA on IFN-β production in RV infection depended on JNK activation. Rotavirus (RV) infection causes serious dehydrating diarrhoea in infants and newborn animals. Our previous study revealed that cyclophilin A (CYPA), a peptidyl-prolyl cis–trans isomerase (PPIase), could be temporarily upregulated in RV-infected MA104 cells in early stage of infection (unpublished data). To find out the possible roles of CYPA in RV infection, we overexpressed and silenced CYPA in various cell lines by gene transfection and shRNA. We found that transfection of CYPA significantly inhibited RV replication, while silencing the expression of CYPA significantly increased RV replication. Accordingly, overexpression of CYPA significantly increased IFN-β production; while silencing CYPA significantly reduced...
language: eng
source:
identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.05.050
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
  • 1090-2104
  • 10902104
url: Link


@attributes
ID796691919
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_bbrc_2012_05_050
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_bbrc_2012_05_050
sourcesystemPC
dbid
0--K
1--M
2.~1
31B1
41RT
51~.
6457
74G.
87-5
98P~
109JM
11AABNK
12AAEDT
13AAKOC
14AAOAW
15AAQFI
16ABFNM
17ABGSF
18ABYKQ
19ACDAQ
20ACRLP
21ADUVX
22AEHWI
23AEKER
24AFKWA
25AFTJW
26AFXIZ
27AGHFR
28AGUBO
29AGYEJ
30AIKHN
31AITUG
32AJBFU
33AJOXV
34AMFUW
35BLXMC
36DOVZS
37EO8
38EO9
39EP2
40EP3
41FDB
42FIRID
43FNPLU
44G-Q
45GBLVA
46J1W
47KOM
48OAUVE
49P-8
50P-9
51PC.
52Q38
53RPZ
54SCC
55SDF
56SDG
57SDP
58SES
59SSU
60SSZ
61T5K
62~G-
pqid1021125155
galeid293403277
display
typearticle
titleCyclophilin A inhibits rotavirus replication by facilitating host IFN-I production
creatorHe, Haiyang ; Zhou, Daijun ; Fan, Weiping ; Fu, Xiaolan ; Zhang, Ji ; Shen, Zigang ; Li, Jian ; Li, Jintao ; Wu, Yuzhang
ispartofBiochemical and Biophysical Research Communications, 15 June 2012, Vol.422(4), pp.664-669
identifier
subjectCyclophilin A ; IFN-I ; Jnk Signaling Pathway ; Rotavirus ; Viral Production ; Biology ; Chemistry ; Anatomy & Physiology
description► CYPA inhibited RV replication in host cells. ► CYPA regulated IFN-β production in RV-infected MA104 cells. ► IFN-β produced by host cells inhibited RV infection. ► The effect of CYPA on IFN-β production in RV infection depended on JNK activation. Rotavirus (RV) infection causes serious dehydrating diarrhoea in infants and newborn animals. Our previous study revealed that cyclophilin A (CYPA), a peptidyl-prolyl cis–trans isomerase (PPIase), could be temporarily upregulated in RV-infected MA104 cells in early stage of infection (unpublished data). To find out the possible roles of CYPA in RV infection, we overexpressed and silenced CYPA in various cell lines by gene transfection and shRNA. We found that transfection of CYPA significantly inhibited RV replication, while silencing the expression of CYPA significantly increased RV replication. Accordingly, overexpression of CYPA significantly increased IFN-β production; while silencing CYPA significantly reduced...
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X12009278$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0He, Haiyang
1Zhou, Daijun
2Fan, Weiping
3Fu, Xiaolan
4Zhang, Ji
5Shen, Zigang
6Li, Jian
7Li, Jintao
8Wu, Yuzhang
titleCyclophilin A inhibits rotavirus replication by facilitating host IFN-I production
description

► CYPA inhibited RV replication in host cells. ► CYPA regulated IFN-β production in RV-infected MA104 cells. ► IFN-β produced by host cells inhibited RV infection. ► The effect of CYPA on IFN-β production in RV infection depended on JNK activation.

Rotavirus (RV) infection causes serious dehydrating diarrhoea in infants and newborn animals. Our previous study revealed that cyclophilin A (CYPA), a peptidyl-prolyl cis–trans isomerase (PPIase), could be temporarily upregulated in RV-infected MA104 cells in early stage of infection (unpublished data). To find out the possible roles of CYPA in RV infection, we overexpressed and silenced CYPA in various cell lines by gene transfection and shRNA. We found that transfection of CYPA significantly inhibited RV replication, while silencing the expression of CYPA significantly increased RV replication. Accordingly, overexpression of CYPA significantly increased IFN-β production; while silencing CYPA significantly reduced...

subject
0Cyclophilin A
1IFN-I
2Jnk Signaling Pathway
3Rotavirus
4Viral Production
5Biology
6Chemistry
7Anatomy & Physiology
general
0English
1Elsevier Inc
210.1016/j.bbrc.2012.05.050
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_bbrc_2012_05_050
issn
00006-291X
10006291X
21090-2104
310902104
rsrctypearticle
creationdate2012
addtitleBiochemical and Biophysical Research Communications
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.~1
31B1
41RT
51~.
6457
74G.
87-5
98P~
109JM
11AABNK
12AAEDT
13AAKOC
14AAOAW
15AAQFI
16ABFNM
17ABGSF
18ABYKQ
19ACDAQ
20ACRLP
21ADUVX
22AEHWI
23AEKER
24AFKWA
25AFTJW
26AFXIZ
27AGHFR
28AGUBO
29AGYEJ
30AIKHN
31AITUG
32AJBFU
33AJOXV
34AMFUW
35BLXMC
36DOVZS
37EO8
38EO9
39EP2
40EP3
41FDB
42FIRID
43FNPLU
44G-Q
45GBLVA
46J1W
47KOM
48OAUVE
49P-8
50P-9
51PC.
52Q38
53RPZ
54SCC
55SDF
56SDG
57SDP
58SES
59SSU
60SSZ
61T5K
62~G-
startdate20120615
enddate20120615
lsr40Biochemical and Biophysical Research Communications, 15 June 2012, Vol.422 (4), pp.664-669
doi10.1016/j.bbrc.2012.05.050
citationpf 664 pt 669 vol 422 issue 4
lsr30VSR-Enriched:[galeid, pqid]
sort
titleCyclophilin A inhibits rotavirus replication by facilitating host IFN-I production
authorHe, Haiyang ; Zhou, Daijun ; Fan, Weiping ; Fu, Xiaolan ; Zhang, Ji ; Shen, Zigang ; Li, Jian ; Li, Jintao ; Wu, Yuzhang
creationdate20120615
lso0120120615
facets
frbrgroupid8759887386405653063
frbrtype5
newrecords20190904
languageeng
topic
0Cyclophilin A
1IFN-I
2Jnk Signaling Pathway
3Rotavirus
4Viral Production
5Biology
6Chemistry
7Anatomy & Physiology
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0He, Haiyang
1Zhou, Daijun
2Fan, Weiping
3Fu, Xiaolan
4Zhang, Ji
5Shen, Zigang
6Li, Jian
7Li, Jintao
8Wu, Yuzhang
jtitleBiochemical and Biophysical Research Communications
creationdate2012
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0He
1Zhou
2Fan
3Fu
4Zhang
5Shen
6Li
7Wu
aufirst
0Haiyang
1Daijun
2Weiping
3Xiaolan
4Ji
5Zigang
6Jian
7Jintao
8Yuzhang
auinitH
auinit1H
au
0He, Haiyang
1Zhou, Daijun
2Fan, Weiping
3Fu, Xiaolan
4Zhang, Ji
5Shen, Zigang
6Li, Jian
7Li, Jintao
8Wu, Yuzhang
atitleCyclophilin A inhibits rotavirus replication by facilitating host IFN-I production
jtitleBiochemical and Biophysical Research Communications
risdate20120615
volume422
issue4
spage664
epage669
pages664-669
issn0006-291X
eissn1090-2104
formatjournal
genrearticle
ristypeJOUR
abstract

► CYPA inhibited RV replication in host cells. ► CYPA regulated IFN-β production in RV-infected MA104 cells. ► IFN-β produced by host cells inhibited RV infection. ► The effect of CYPA on IFN-β production in RV infection depended on JNK activation.

Rotavirus (RV) infection causes serious dehydrating diarrhoea in infants and newborn animals. Our previous study revealed that cyclophilin A (CYPA), a peptidyl-prolyl cis–trans isomerase (PPIase), could be temporarily upregulated in RV-infected MA104 cells in early stage of infection (unpublished data). To find out the possible roles of CYPA in RV infection, we overexpressed and silenced CYPA in various cell lines by gene transfection and shRNA. We found that transfection of CYPA significantly inhibited RV replication, while silencing the expression of CYPA significantly increased RV replication. Accordingly, overexpression of CYPA significantly increased IFN-β production; while silencing CYPA significantly reduced...

pubElsevier Inc
doi10.1016/j.bbrc.2012.05.050
lad01Biochemical and Biophysical Research Communications
date2012-06-15