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Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell

► miR-130a levels were significantly increased after cisplatin treatment. ► Upregulated miR-130a contributed to cisplatin resistance in Huh7 cell. ► Activation of Wnt signaling was increased after cisplatin treatment. ► Cisplatin-induced miR-130a increases drug resistance by regulating RUNX3 and Wnt... Full description

Journal Title: Biochemical and Biophysical Research Communications 24 August 2012, Vol.425(2), pp.468-472
Main Author: Xu, Ning
Other Authors: Shen, Conghuan , Luo, Yi , Xia, Lei , Xue, Feng , Xia, Qiang , Zhang, Jianjun
Format: Electronic Article Electronic Article
Language: English
Subjects:
Wnt
ID: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.07.127
Link: https://www.sciencedirect.com/science/article/pii/S0006291X12014349
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recordid: elsevier_sdoi_10_1016_j_bbrc_2012_07_127
title: Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell
format: Article
creator:
  • Xu, Ning
  • Shen, Conghuan
  • Luo, Yi
  • Xia, Lei
  • Xue, Feng
  • Xia, Qiang
  • Zhang, Jianjun
subjects:
  • Cisplatin
  • Chemoresistance
  • Mir-130a
  • Runx3
  • Wnt
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: Biochemical and Biophysical Research Communications, 24 August 2012, Vol.425(2), pp.468-472
description: ► miR-130a levels were significantly increased after cisplatin treatment. ► Upregulated miR-130a contributed to cisplatin resistance in Huh7 cell. ► Activation of Wnt signaling was increased after cisplatin treatment. ► Cisplatin-induced miR-130a increases drug resistance by regulating RUNX3 and Wnt. Cisplatin is one of the commonly used chemotherapeutic drugs for the treatment of patients with advanced liver cancer. However, acquisition of cisplatin resistance is common in patients with hepatocellular carcinoma (HCC), and the underlying mechanism of such resistance is not fully understood. In the study, we found that miR-130a levels were significantly increased in HCC patients treated with cisplatin-based chemotherapy. miR-130a levels were also higher in cisplatin-resistant Huh7 cells than in Huh7 cells. Overexpression of miR-130a contributed to cisplatin resistance in Huh7 cell, whereas knockdown of miR-130a overcame cisplatin resistance in cisplatin-resistant Huh7 cell. We further demonstrated that upregulated miR-130a directly inhibited expression of tumor suppressor gene RUNX3, which resulted in activation of Wnt/β-catenin signaling and increased drug resistance. These data suggest that miR-130a/RUNX3/Wnt signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of HCC.
language: eng
source:
identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.07.127
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
  • 1090-2104
  • 10902104
url: Link


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titleUpregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell
creatorXu, Ning ; Shen, Conghuan ; Luo, Yi ; Xia, Lei ; Xue, Feng ; Xia, Qiang ; Zhang, Jianjun
ispartofBiochemical and Biophysical Research Communications, 24 August 2012, Vol.425(2), pp.468-472
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subjectCisplatin ; Chemoresistance ; Mir-130a ; Runx3 ; Wnt ; Biology ; Chemistry ; Anatomy & Physiology
description► miR-130a levels were significantly increased after cisplatin treatment. ► Upregulated miR-130a contributed to cisplatin resistance in Huh7 cell. ► Activation of Wnt signaling was increased after cisplatin treatment. ► Cisplatin-induced miR-130a increases drug resistance by regulating RUNX3 and Wnt. Cisplatin is one of the commonly used chemotherapeutic drugs for the treatment of patients with advanced liver cancer. However, acquisition of cisplatin resistance is common in patients with hepatocellular carcinoma (HCC), and the underlying mechanism of such resistance is not fully understood. In the study, we found that miR-130a levels were significantly increased in HCC patients treated with cisplatin-based chemotherapy. miR-130a levels were also higher in cisplatin-resistant Huh7 cells than in Huh7 cells. Overexpression of miR-130a contributed to cisplatin resistance in Huh7 cell, whereas knockdown of miR-130a overcame cisplatin resistance in cisplatin-resistant Huh7 cell. We further demonstrated that upregulated miR-130a directly inhibited expression of tumor suppressor gene RUNX3, which resulted in activation of Wnt/β-catenin signaling and increased drug resistance. These data suggest that miR-130a/RUNX3/Wnt signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of HCC.
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titleUpregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell
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► miR-130a levels were significantly increased after cisplatin treatment. ► Upregulated miR-130a contributed to cisplatin resistance in Huh7 cell. ► Activation of Wnt signaling was increased after cisplatin treatment. ► Cisplatin-induced miR-130a increases drug resistance by regulating RUNX3 and Wnt.

Cisplatin is one of the commonly used chemotherapeutic drugs for the treatment of patients with advanced liver cancer. However, acquisition of cisplatin resistance is common in patients with hepatocellular carcinoma (HCC), and the underlying mechanism of such resistance is not fully understood. In the study, we found that miR-130a levels were significantly increased in HCC patients treated with cisplatin-based chemotherapy. miR-130a levels were also higher in cisplatin-resistant Huh7 cells than in Huh7 cells. Overexpression of miR-130a contributed to cisplatin resistance in Huh7 cell, whereas knockdown of miR-130a overcame cisplatin resistance in cisplatin-resistant Huh7 cell. We further demonstrated that upregulated miR-130a directly inhibited expression of tumor suppressor gene RUNX3, which resulted in activation of Wnt/β-catenin signaling and increased drug resistance. These data suggest that miR-130a/RUNX3/Wnt signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of HCC.

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► miR-130a levels were significantly increased after cisplatin treatment. ► Upregulated miR-130a contributed to cisplatin resistance in Huh7 cell. ► Activation of Wnt signaling was increased after cisplatin treatment. ► Cisplatin-induced miR-130a increases drug resistance by regulating RUNX3 and Wnt.

Cisplatin is one of the commonly used chemotherapeutic drugs for the treatment of patients with advanced liver cancer. However, acquisition of cisplatin resistance is common in patients with hepatocellular carcinoma (HCC), and the underlying mechanism of such resistance is not fully understood. In the study, we found that miR-130a levels were significantly increased in HCC patients treated with cisplatin-based chemotherapy. miR-130a levels were also higher in cisplatin-resistant Huh7 cells than in Huh7 cells. Overexpression of miR-130a contributed to cisplatin resistance in Huh7 cell, whereas knockdown of miR-130a overcame cisplatin resistance in cisplatin-resistant Huh7 cell. We further demonstrated that upregulated miR-130a directly inhibited expression of tumor suppressor gene RUNX3, which resulted in activation of Wnt/β-catenin signaling and increased drug resistance. These data suggest that miR-130a/RUNX3/Wnt signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of HCC.

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date2012-08-24