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Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4

► Cereblon (CRBN) directly interacts with the 20S proteasome subunit PSMB4. ► GFPu accumulates in cells expressing exogenous CRBN. ► Suppressing endogenous CRBN strongly enhances proteasome activity. In humans, mutations in the gene encoding cereblon (CRBN) are associated with mental retardation. Al... Full description

Journal Title: Biochemical and Biophysical Research Communications 26 October 2012, Vol.427(3), pp.618-622
Main Author: Lee, Kwang Min
Other Authors: Lee, Jongwon , Park, Chul-Seung
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.09.108
Link: http://dx.doi.org/10.1016/j.bbrc.2012.09.108
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recordid: elsevier_sdoi_10_1016_j_bbrc_2012_09_108
title: Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4
format: Article
creator:
  • Lee, Kwang Min
  • Lee, Jongwon
  • Park, Chul-Seung
subjects:
  • Cereblon
  • Proteasome Subunit Beta Type 4
  • Binding Protein
  • Proteasome Activity
  • Cereblon
  • Proteasome Subunit Beta Type 4
  • Binding Protein
  • Proteasome Activity
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: Biochemical and Biophysical Research Communications, 26 October 2012, Vol.427(3), pp.618-622
description: ► Cereblon (CRBN) directly interacts with the 20S proteasome subunit PSMB4. ► GFPu accumulates in cells expressing exogenous CRBN. ► Suppressing endogenous CRBN strongly enhances proteasome activity. In humans, mutations in the gene encoding cereblon (CRBN) are associated with mental retardation. Although CRBN has been investigated in several cellular contexts, its function remains unclear. Here, we demonstrate that CRBN plays a role in regulating the ubiquitin–proteasome system (UPS). Heterologous expression of CRBN inhibited proteasome activity in a human neuroblastoma cell line. Furthermore, proteasome subunit beta type 4 (PSMB4), the β7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. These findings suggest that CRBN may modulate proteasome activity by directly interacting with the β7 subunit.
language: eng
source:
identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.09.108
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
  • 1090-2104
  • 10902104
url: Link


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titleCereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4
creatorLee, Kwang Min ; Lee, Jongwon ; Park, Chul-Seung
ispartofBiochemical and Biophysical Research Communications, 26 October 2012, Vol.427(3), pp.618-622
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subjectCereblon ; Proteasome Subunit Beta Type 4 ; Binding Protein ; Proteasome Activity ; Cereblon ; Proteasome Subunit Beta Type 4 ; Binding Protein ; Proteasome Activity ; Biology ; Chemistry ; Anatomy & Physiology
description► Cereblon (CRBN) directly interacts with the 20S proteasome subunit PSMB4. ► GFPu accumulates in cells expressing exogenous CRBN. ► Suppressing endogenous CRBN strongly enhances proteasome activity. In humans, mutations in the gene encoding cereblon (CRBN) are associated with mental retardation. Although CRBN has been investigated in several cellular contexts, its function remains unclear. Here, we demonstrate that CRBN plays a role in regulating the ubiquitin–proteasome system (UPS). Heterologous expression of CRBN inhibited proteasome activity in a human neuroblastoma cell line. Furthermore, proteasome subunit beta type 4 (PSMB4), the β7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. These findings suggest that CRBN may modulate proteasome activity by directly interacting with the β7 subunit.
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► Cereblon (CRBN) directly interacts with the 20S proteasome subunit PSMB4. ► GFPu accumulates in cells expressing exogenous CRBN. ► Suppressing endogenous CRBN strongly enhances proteasome activity.

In humans, mutations in the gene encoding cereblon (CRBN) are associated with mental retardation. Although CRBN has been investigated in several cellular contexts, its function remains unclear. Here, we demonstrate that CRBN plays a role in regulating the ubiquitin–proteasome system (UPS). Heterologous expression of CRBN inhibited proteasome activity in a human neuroblastoma cell line. Furthermore, proteasome subunit beta type 4 (PSMB4), the β7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. These findings suggest that CRBN may modulate proteasome activity by directly interacting with the β7 subunit.

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► Cereblon (CRBN) directly interacts with the 20S proteasome subunit PSMB4. ► GFPu accumulates in cells expressing exogenous CRBN. ► Suppressing endogenous CRBN strongly enhances proteasome activity.

In humans, mutations in the gene encoding cereblon (CRBN) are associated with mental retardation. Although CRBN has been investigated in several cellular contexts, its function remains unclear. Here, we demonstrate that CRBN plays a role in regulating the ubiquitin–proteasome system (UPS). Heterologous expression of CRBN inhibited proteasome activity in a human neuroblastoma cell line. Furthermore, proteasome subunit beta type 4 (PSMB4), the β7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. These findings suggest that CRBN may modulate proteasome activity by directly interacting with the β7 subunit.

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lad01Biochemical and Biophysical Research Communications
date2012-10-26