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Soluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response

► AβO induces more impairment of learning and memory function than FAβ. ► AβO stimulates more inflammatory response than FAβ. ► AβO activates more NF-κB transcriptional signaling than FAβ. Two major active species of β-amyloid protein (Aβ), fibrillar Aβ1-42 (FAβ) and soluble Aβ1-42 oligomers (AβO),... Full description

Journal Title: Biochemical and Biophysical Research Communications 14 December 2012, Vol.429(3-4), pp.125-130
Main Author: He, Yan
Other Authors: Zheng, Mei-Mei , Ma, Yan , Han, Xiao-Juan , Ma, Xue-Qiang , Qu, Chuan-Qiang , Du, Yi-Feng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.10.129
Link: https://www.sciencedirect.com/science/article/pii/S0006291X12021377
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recordid: elsevier_sdoi_10_1016_j_bbrc_2012_10_129
title: Soluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response
format: Article
creator:
  • He, Yan
  • Zheng, Mei-Mei
  • Ma, Yan
  • Han, Xiao-Juan
  • Ma, Xue-Qiang
  • Qu, Chuan-Qiang
  • Du, Yi-Feng
subjects:
  • Fibrillar Aβ1-42
  • Soluble Aβ1-42 Oligomers
  • Inflammatory Response
  • Nf-Κb
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: Biochemical and Biophysical Research Communications, 14 December 2012, Vol.429(3-4), pp.125-130
description: ► AβO induces more impairment of learning and memory function than FAβ. ► AβO stimulates more inflammatory response than FAβ. ► AβO activates more NF-κB transcriptional signaling than FAβ. Two major active species of β-amyloid protein (Aβ), fibrillar Aβ1-42 (FAβ) and soluble Aβ1-42 oligomers (AβO), are known to play important roles in the pathogenesis of Alzheimer’s disease. However, the differences between them are largely unknown. In this study, we explored the effects of FAβ and AβO on cognitive functions and hippocampal inflammatory response through a 30-days infusion of FAβ or AβO (144 pmol/d) into the left lateral ventricles of the rat brain. Morris water maze showed that the impairment of learning and memory functions was much more significant in the AβO-infused rats, compared to the FAβ-infused rats. AβO-induced neurodegeneration and ultrastructure damage in CA1 neurons were more remarkable than those induced by FAβ. Compared to FAβ,...
language: eng
source:
identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2012.10.129
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
  • 1090-2104
  • 10902104
url: Link


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titleSoluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response
creatorHe, Yan ; Zheng, Mei-Mei ; Ma, Yan ; Han, Xiao-Juan ; Ma, Xue-Qiang ; Qu, Chuan-Qiang ; Du, Yi-Feng
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subjectFibrillar Aβ1-42 ; Soluble Aβ1-42 Oligomers ; Inflammatory Response ; Nf-Κb ; Biology ; Chemistry ; Anatomy & Physiology
description► AβO induces more impairment of learning and memory function than FAβ. ► AβO stimulates more inflammatory response than FAβ. ► AβO activates more NF-κB transcriptional signaling than FAβ. Two major active species of β-amyloid protein (Aβ), fibrillar Aβ1-42 (FAβ) and soluble Aβ1-42 oligomers (AβO), are known to play important roles in the pathogenesis of Alzheimer’s disease. However, the differences between them are largely unknown. In this study, we explored the effects of FAβ and AβO on cognitive functions and hippocampal inflammatory response through a 30-days infusion of FAβ or AβO (144 pmol/d) into the left lateral ventricles of the rat brain. Morris water maze showed that the impairment of learning and memory functions was much more significant in the AβO-infused rats, compared to the FAβ-infused rats. AβO-induced neurodegeneration and ultrastructure damage in CA1 neurons were more remarkable than those induced by FAβ. Compared to FAβ,...
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titleSoluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response
description

► AβO induces more impairment of learning and memory function than FAβ. ► AβO stimulates more inflammatory response than FAβ. ► AβO activates more NF-κB transcriptional signaling than FAβ.

Two major active species of β-amyloid protein (Aβ), fibrillar Aβ1-42 (FAβ) and soluble Aβ1-42 oligomers (AβO), are known to play important roles in the pathogenesis of Alzheimer’s disease. However, the differences between them are largely unknown. In this study, we explored the effects of FAβ and AβO on cognitive functions and hippocampal inflammatory response through a 30-days infusion of FAβ or AβO (144

pmol/d) into the left lateral ventricles of the rat brain. Morris water maze showed that the impairment of learning and memory functions was much more significant in the AβO-infused rats, compared to the FAβ-infused rats. AβO-induced neurodegeneration and ultrastructure damage in CA1 neurons were more remarkable than those induced by FAβ. Compared to FAβ,...

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titleSoluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response
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► AβO induces more impairment of learning and memory function than FAβ. ► AβO stimulates more inflammatory response than FAβ. ► AβO activates more NF-κB transcriptional signaling than FAβ.

Two major active species of β-amyloid protein (Aβ), fibrillar Aβ1-42 (FAβ) and soluble Aβ1-42 oligomers (AβO), are known to play important roles in the pathogenesis of Alzheimer’s disease. However, the differences between them are largely unknown. In this study, we explored the effects of FAβ and AβO on cognitive functions and hippocampal inflammatory response through a 30-days infusion of FAβ or AβO (144

pmol/d) into the left lateral ventricles of the rat brain. Morris water maze showed that the impairment of learning and memory functions was much more significant in the AβO-infused rats, compared to the FAβ-infused rats. AβO-induced neurodegeneration and ultrastructure damage in CA1 neurons were more remarkable than those induced by FAβ. Compared to FAβ,...

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doi10.1016/j.bbrc.2012.10.129
lad01Biochemical and Biophysical Research Communications
date2012-12-14