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Collagen composite hydrogels for vocal fold lamina propria restoration

Chronic voice impairment due to scarring of the vocal fold (VF) lamina propria (LP) can be debilitating in terms of quality of life. Due to the dependence of normal VF vibration on proper VF geometry, an implant inserted to restore appropriate shape and pliability to scarred LP should ideally mainta... Full description

Journal Title: Biomaterials 2006, Vol.27(7), pp.1104-1109
Main Author: Hahn, Mariah S
Other Authors: Teply, Benjamin A , Stevens, Molly M , Zeitels, Steven M , Langer, Robert
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2005.07.022
Link: https://www.sciencedirect.com/science/article/pii/S0142961205006307
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2005_07_022
title: Collagen composite hydrogels for vocal fold lamina propria restoration
format: Article
creator:
  • Hahn, Mariah S
  • Teply, Benjamin A
  • Stevens, Molly M
  • Zeitels, Steven M
  • Langer, Robert
subjects:
  • Vocal Fold
  • Tissue Engineering
  • Augmentation
  • Hydrogel
  • Collagen
  • Hyaluronan
  • Medicine
  • Engineering
ispartof: Biomaterials, 2006, Vol.27(7), pp.1104-1109
description: Chronic voice impairment due to scarring of the vocal fold (VF) lamina propria (LP) can be debilitating in terms of quality of life. Due to the dependence of normal VF vibration on proper VF geometry, an implant inserted to restore appropriate shape and pliability to scarred LP should ideally maintain its insertion-dimensions while being replaced by newly synthesized extracellular matrix (ECM). In the present study, collagen–alginate and collagen–hyaluronan (HA) composite hydrogels were investigated for their ability to support ECM synthesis by VF fibroblasts with limited hydrogel compaction and/or resorption. Collagen–HA composites showed significant mass loss over 28 days of culture, with little evidence of new matrix production. Collagen–alginate composites, in contrast, resisted scaffold compaction and mass loss for at least 42 days in culture while allowing for ECM synthesis. Collagen–alginate hydrogels appear to be promising materials for VF restoration, warranting further...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2005.07.022
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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subjectVocal Fold ; Tissue Engineering ; Augmentation ; Hydrogel ; Collagen ; Hyaluronan ; Medicine ; Engineering
descriptionChronic voice impairment due to scarring of the vocal fold (VF) lamina propria (LP) can be debilitating in terms of quality of life. Due to the dependence of normal VF vibration on proper VF geometry, an implant inserted to restore appropriate shape and pliability to scarred LP should ideally maintain its insertion-dimensions while being replaced by newly synthesized extracellular matrix (ECM). In the present study, collagen–alginate and collagen–hyaluronan (HA) composite hydrogels were investigated for their ability to support ECM synthesis by VF fibroblasts with limited hydrogel compaction and/or resorption. Collagen–HA composites showed significant mass loss over 28 days of culture, with little evidence of new matrix production. Collagen–alginate composites, in contrast, resisted scaffold compaction and mass loss for at least 42 days in culture while allowing for ECM synthesis. Collagen–alginate hydrogels appear to be promising materials for VF restoration, warranting further...
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Chronic voice impairment due to scarring of the vocal fold (VF) lamina propria (LP) can be debilitating in terms of quality of life. Due to the dependence of normal VF vibration on proper VF geometry, an implant inserted to restore appropriate shape and pliability to scarred LP should ideally maintain its insertion-dimensions while being replaced by newly synthesized extracellular matrix (ECM). In the present study, collagen–alginate and collagen–hyaluronan (HA) composite hydrogels were investigated for their ability to support ECM synthesis by VF fibroblasts with limited hydrogel compaction and/or resorption. Collagen–HA composites showed significant mass loss over 28 days of culture, with little evidence of new matrix production. Collagen–alginate composites, in contrast, resisted scaffold compaction and mass loss for at least 42 days in culture while allowing for ECM synthesis. Collagen–alginate hydrogels appear to be promising materials for VF restoration, warranting further...

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Chronic voice impairment due to scarring of the vocal fold (VF) lamina propria (LP) can be debilitating in terms of quality of life. Due to the dependence of normal VF vibration on proper VF geometry, an implant inserted to restore appropriate shape and pliability to scarred LP should ideally maintain its insertion-dimensions while being replaced by newly synthesized extracellular matrix (ECM). In the present study, collagen–alginate and collagen–hyaluronan (HA) composite hydrogels were investigated for their ability to support ECM synthesis by VF fibroblasts with limited hydrogel compaction and/or resorption. Collagen–HA composites showed significant mass loss over 28 days of culture, with little evidence of new matrix production. Collagen–alginate composites, in contrast, resisted scaffold compaction and mass loss for at least 42 days in culture while allowing for ECM synthesis. Collagen–alginate hydrogels appear to be promising materials for VF restoration, warranting further...

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