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The effects of cell–matrix interactions on encapsulated β-cell function within hydrogels functionalized with matrix-derived adhesive peptides

The influence of matrix-derived adhesive peptide sequences on encapsulated -cell survival and glucose-stimulated insulin release was explored by covalently incorporating synthetic peptide sequences within a model encapsulation environment. Photopolymerized poly(ethylene glycol) (PEG) hydrogels were... Full description

Journal Title: Biomaterials 2007, Vol.28(19), pp.3004-3011
Main Author: Weber, Laney M
Other Authors: Hayda, Kirsten N , Haskins, Kathryn , Anseth, Kristi S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2007.03.005
Link: https://www.sciencedirect.com/science/article/pii/S0142961207002244
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2007_03_005
title: The effects of cell–matrix interactions on encapsulated β-cell function within hydrogels functionalized with matrix-derived adhesive peptides
format: Article
creator:
  • Weber, Laney M
  • Hayda, Kirsten N
  • Haskins, Kathryn
  • Anseth, Kristi S
subjects:
  • Cell Encapsulation
  • Peptide
  • Hydrogel
  • Β-Cell
  • Laminin
  • Medicine
  • Engineering
ispartof: Biomaterials, 2007, Vol.28(19), pp.3004-3011
description: The influence of matrix-derived adhesive peptide sequences on encapsulated -cell survival and glucose-stimulated insulin release was explored by covalently incorporating synthetic peptide sequences within a model encapsulation environment. Photopolymerized poly(ethylene glycol) (PEG) hydrogels were functionalized via the addition of acrylate-PEG-peptide conjugates to the polymer precursor solution prior to -cell photoencapsulation. Individual MIN6 -cells were encapsulated in the presence of the laminin-derived recognition sequences, IKLLI, IKVAV, LRE, PDSGR, RGD, and YIGSR, and the collagen type I sequence, DGEA. In the absence of cell–cell and cell–matrix contacts, encapsulated MIN6 -cell survival diminishes within one week; however, in PEG hydrogel derivatives including the laminin sequences IKLLI and IKVAV, encapsulated -cells exhibit preserved viability,...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2007.03.005
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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descriptionThe influence of matrix-derived adhesive peptide sequences on encapsulated -cell survival and glucose-stimulated insulin release was explored by covalently incorporating synthetic peptide sequences within a model encapsulation environment. Photopolymerized poly(ethylene glycol) (PEG) hydrogels were functionalized via the addition of acrylate-PEG-peptide conjugates to the polymer precursor solution prior to -cell photoencapsulation. Individual MIN6 -cells were encapsulated in the presence of the laminin-derived recognition sequences, IKLLI, IKVAV, LRE, PDSGR, RGD, and YIGSR, and the collagen type I sequence, DGEA. In the absence of cell–cell and cell–matrix contacts, encapsulated MIN6 -cell survival diminishes within one week; however, in PEG hydrogel derivatives including the laminin sequences IKLLI and IKVAV, encapsulated -cells exhibit preserved viability,...
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