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Using living radical polymerization to enable facile incorporation of materials in microfluidic cell culture devices

High throughput screening tools are expediting cell culture studies with applications in drug discovery and tissue engineering. This contribution demonstrates a method to incorporate 3D cell culture sites into microfluidic devices and enables the fabrication of high throughput screening tools with u... Full description

Journal Title: Biomaterials 2008, Vol.29(14), pp.2228-2236
Main Author: Simms, Helen M
Other Authors: Bowman, Christopher M , Anseth, Kristi S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2008.02.001
Link: http://dx.doi.org/10.1016/j.biomaterials.2008.02.001
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2008_02_001
title: Using living radical polymerization to enable facile incorporation of materials in microfluidic cell culture devices
format: Article
creator:
  • Simms, Helen M
  • Bowman, Christopher M
  • Anseth, Kristi S
subjects:
  • Three-Dimensional
  • Scaffold
  • Hydrogel
  • Photopolymerization
  • Photolithography
  • Tissue Engineering
  • Three-Dimensional
  • Scaffold
  • Hydrogel
  • Photopolymerization
  • Photolithography
  • Tissue Engineering
  • Medicine
  • Engineering
ispartof: Biomaterials, 2008, Vol.29(14), pp.2228-2236
description: High throughput screening tools are expediting cell culture studies with applications in drug discovery and tissue engineering. This contribution demonstrates a method to incorporate 3D cell culture sites into microfluidic devices and enables the fabrication of high throughput screening tools with uniquely addressable culture environments. Contact lithographic photopolymerization (CLiPP) was used to fabricate microfluidic devices with two types of 3D culture sites: macroporous rigid polymer cell scaffolds and poly(ethylene glycol) (PEG) encapsulated cell matrices. Cells were cultured on-device with both types of culture sites, demonstrating material cytocompatibility. Multilayer microfluidic devices were fabricated with channels passing the top and bottom sides of a series of rigid porous polymer scaffolds. Cells were seeded and cultured on device, demonstrating the ability to deliver cells and culture cells on multiple scaffolds along the length of a single channel. Flow control...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2008.02.001
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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subjectThree-Dimensional ; Scaffold ; Hydrogel ; Photopolymerization ; Photolithography ; Tissue Engineering ; Three-Dimensional ; Scaffold ; Hydrogel ; Photopolymerization ; Photolithography ; Tissue Engineering ; Medicine ; Engineering
descriptionHigh throughput screening tools are expediting cell culture studies with applications in drug discovery and tissue engineering. This contribution demonstrates a method to incorporate 3D cell culture sites into microfluidic devices and enables the fabrication of high throughput screening tools with uniquely addressable culture environments. Contact lithographic photopolymerization (CLiPP) was used to fabricate microfluidic devices with two types of 3D culture sites: macroporous rigid polymer cell scaffolds and poly(ethylene glycol) (PEG) encapsulated cell matrices. Cells were cultured on-device with both types of culture sites, demonstrating material cytocompatibility. Multilayer microfluidic devices were fabricated with channels passing the top and bottom sides of a series of rigid porous polymer scaffolds. Cells were seeded and cultured on device, demonstrating the ability to deliver cells and culture cells on multiple scaffolds along the length of a single channel. Flow control...
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abstract

High throughput screening tools are expediting cell culture studies with applications in drug discovery and tissue engineering. This contribution demonstrates a method to incorporate 3D cell culture sites into microfluidic devices and enables the fabrication of high throughput screening tools with uniquely addressable culture environments. Contact lithographic photopolymerization (CLiPP) was used to fabricate microfluidic devices with two types of 3D culture sites: macroporous rigid polymer cell scaffolds and poly(ethylene glycol) (PEG) encapsulated cell matrices. Cells were cultured on-device with both types of culture sites, demonstrating material cytocompatibility. Multilayer microfluidic devices were fabricated with channels passing the top and bottom sides of a series of rigid porous polymer scaffolds. Cells were seeded and cultured on device, demonstrating the ability to deliver cells and culture cells on multiple scaffolds along the length of a single channel. Flow control...

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