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Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells

Type I Collagen matrices of defined porosity, incorporating carbonate substituted hydroxyapatite (HA) crystals, were assessed for their ability to support osteo- and chondrogenic differentiation of human bone marrow stromal cells (HBMSCs). Collagen–HA composite scaffolds supported the osteogenic dif... Full description

Journal Title: Biomaterials 2008, Vol.29(21), pp.3105-3116
Main Author: Dawson, Jonathan I
Other Authors: Wahl, Denys A , Lanham, Stuart A , Kanczler, Janos M , Czernuszka, Jan T , Oreffo, Richard O.C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2008.03.040
Link: https://www.sciencedirect.com/science/article/pii/S0142961208002044
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2008_03_040
title: Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells
format: Article
creator:
  • Dawson, Jonathan I
  • Wahl, Denys A
  • Lanham, Stuart A
  • Kanczler, Janos M
  • Czernuszka, Jan T
  • Oreffo, Richard O.C
subjects:
  • Bone Tissue Engineering
  • Cartilage Tissue Engineering
  • Collagen
  • Scaffold
  • Biomimetic Material
  • Medicine
  • Engineering
ispartof: Biomaterials, 2008, Vol.29(21), pp.3105-3116
description: Type I Collagen matrices of defined porosity, incorporating carbonate substituted hydroxyapatite (HA) crystals, were assessed for their ability to support osteo- and chondrogenic differentiation of human bone marrow stromal cells (HBMSCs). Collagen–HA composite scaffolds supported the osteogenic differentiation of HBMSCs both and as demonstrated by histological and micro-CT analyses indicating the extensive penetration of alkaline phosphatase expressing cells and new matrix synthesis with localised areas immunologically positive for osteocalcin. , extensive new osteoid formation of implant origin was observed in the areas of vasculature. Chondrogenic matrix synthesis was evidenced in the peripheral regions of pure collagen systems by an abundance of Sox9 expressing chondrocytes embedded within a proteoglycan and collagen II rich ECM. The introduction of microchannels to the scaffold architecture was seen...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2008.03.040
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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descriptionType I Collagen matrices of defined porosity, incorporating carbonate substituted hydroxyapatite (HA) crystals, were assessed for their ability to support osteo- and chondrogenic differentiation of human bone marrow stromal cells (HBMSCs). Collagen–HA composite scaffolds supported the osteogenic differentiation of HBMSCs both and as demonstrated by histological and micro-CT analyses indicating the extensive penetration of alkaline phosphatase expressing cells and new matrix synthesis with localised areas immunologically positive for osteocalcin. , extensive new osteoid formation of implant origin was observed in the areas of vasculature. Chondrogenic matrix synthesis was evidenced in the peripheral regions of pure collagen systems by an abundance of Sox9 expressing chondrocytes embedded within a proteoglycan and collagen II rich ECM. The introduction of microchannels to the scaffold architecture was seen...
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