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Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites

The development of particulate bone void fillers with added biological function to augment skeletal tissue formation will lead to improved efficacy in bone replacement surgery. We demonstrate the potential for vaterite microsphere biocomposites to augment bone matrix formation within an model for im... Full description

Journal Title: Biomaterials 2009, Vol.30(10), pp.1918-1927
Main Author: Green, David W
Other Authors: Bolland, Benjamin J.R.F , Kanczler, Janos M , Lanham, Stuart A , Walsh, Dominic , Mann, Stephen , Oreffo, Richard O.C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2008.12.052
Link: https://www.sciencedirect.com/science/article/pii/S0142961208010144
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2008_12_052
title: Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites
format: Article
creator:
  • Green, David W
  • Bolland, Benjamin J.R.F
  • Kanczler, Janos M
  • Lanham, Stuart A
  • Walsh, Dominic
  • Mann, Stephen
  • Oreffo, Richard O.C
subjects:
  • Human Osteoprogenitor
  • Calcium Carbonate
  • Osteogenesis
  • Biomimetic Material
  • Mineralization
  • Bone Tissue Engineering
  • Medicine
  • Engineering
ispartof: Biomaterials, 2009, Vol.30(10), pp.1918-1927
description: The development of particulate bone void fillers with added biological function to augment skeletal tissue formation will lead to improved efficacy in bone replacement surgery. We demonstrate the potential for vaterite microsphere biocomposites to augment bone matrix formation within an model for impaction bone grafting seeded with human bone marrow stromal cells. tests demonstrate the significance of vaterite microspheres in the activation and promotion of 3D skeletal tissue formation. Further experiments using functionalized microspheres with surface integrated RGD peptide activate co-cultured skeletal populations in pellets and promote secretion of extracellular matrix collagens and human osteocalcin. Specific temporal release of entrapped RNase A was successfully demonstrated using these specialized microspheres with integrated magnetic beads, which physically disrupted the inorganic macrostructure....
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2008.12.052
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleAugmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites
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subjectHuman Osteoprogenitor ; Calcium Carbonate ; Osteogenesis ; Biomimetic Material ; Mineralization ; Bone Tissue Engineering ; Medicine ; Engineering
descriptionThe development of particulate bone void fillers with added biological function to augment skeletal tissue formation will lead to improved efficacy in bone replacement surgery. We demonstrate the potential for vaterite microsphere biocomposites to augment bone matrix formation within an model for impaction bone grafting seeded with human bone marrow stromal cells. tests demonstrate the significance of vaterite microspheres in the activation and promotion of 3D skeletal tissue formation. Further experiments using functionalized microspheres with surface integrated RGD peptide activate co-cultured skeletal populations in pellets and promote secretion of extracellular matrix collagens and human osteocalcin. Specific temporal release of entrapped RNase A was successfully demonstrated using these specialized microspheres with integrated magnetic beads, which physically disrupted the inorganic macrostructure....
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