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The encapsulation of DNA molecules within biomimetic lipid nanocapsules

Most of DNA synthetic complexes result from the self-assembly of DNA molecules with cationic lipids or polymers in an aqueous controlled medium. However, injection of such self-assembled complexes in medium like blood that differ from that of their formulation leads to strong instability. Therefore,... Full description

Journal Title: Biomaterials 2009, Vol.30(18), pp.3197-3204
Main Author: Vonarbourg, Arnaud
Other Authors: Passirani, Catherine , Desigaux, Léa , Allard, Emilie , Saulnier, Patrick , Lambert, Olivier , Benoit, Jean-Pierre , Pitard, Bruno
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
DNA
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.03.009
Link: http://dx.doi.org/10.1016/j.biomaterials.2009.03.009
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2009_03_009
title: The encapsulation of DNA molecules within biomimetic lipid nanocapsules
format: Article
creator:
  • Vonarbourg, Arnaud
  • Passirani, Catherine
  • Desigaux, Léa
  • Allard, Emilie
  • Saulnier, Patrick
  • Lambert, Olivier
  • Benoit, Jean-Pierre
  • Pitard, Bruno
subjects:
  • DNA
  • Liposome
  • Nanoparticle
  • Stealthiness
  • Poly(Ethylene Glycol)
  • Blood
  • DNA
  • Liposome
  • Nanoparticle
  • Stealthiness
  • Poly(Ethylene Glycol)
  • Blood
  • Medicine
  • Engineering
ispartof: Biomaterials, 2009, Vol.30(18), pp.3197-3204
description: Most of DNA synthetic complexes result from the self-assembly of DNA molecules with cationic lipids or polymers in an aqueous controlled medium. However, injection of such self-assembled complexes in medium like blood that differ from that of their formulation leads to strong instability. Therefore, DNA vectors that have physico-chemical properties and structural organisation that will not be sensitive to a completely different medium in terms of ionic and protein composition are actively sought. To this end, the goal here was to discover and optimize a nanostructured system where DNA molecules would be encapsulated in nanocapsules consisting in an oily core and a shell covered by PEG stretches obtained through a nanoemulsion process in the absence of organic solvent. This encapsulation form of DNA molecules would prevent interactions with external hostile biological fluid. The results show the entrapment of lipoplexes into lipid nanocapsules, leading to the formation of neutral...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.03.009
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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subjectDNA ; Liposome ; Nanoparticle ; Stealthiness ; Poly(Ethylene Glycol) ; Blood ; DNA ; Liposome ; Nanoparticle ; Stealthiness ; Poly(Ethylene Glycol) ; Blood ; Medicine ; Engineering
descriptionMost of DNA synthetic complexes result from the self-assembly of DNA molecules with cationic lipids or polymers in an aqueous controlled medium. However, injection of such self-assembled complexes in medium like blood that differ from that of their formulation leads to strong instability. Therefore, DNA vectors that have physico-chemical properties and structural organisation that will not be sensitive to a completely different medium in terms of ionic and protein composition are actively sought. To this end, the goal here was to discover and optimize a nanostructured system where DNA molecules would be encapsulated in nanocapsules consisting in an oily core and a shell covered by PEG stretches obtained through a nanoemulsion process in the absence of organic solvent. This encapsulation form of DNA molecules would prevent interactions with external hostile biological fluid. The results show the entrapment of lipoplexes into lipid nanocapsules, leading to the formation of neutral...
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Most of DNA synthetic complexes result from the self-assembly of DNA molecules with cationic lipids or polymers in an aqueous controlled medium. However, injection of such self-assembled complexes in medium like blood that differ from that of their formulation leads to strong instability. Therefore, DNA vectors that have physico-chemical properties and structural organisation that will not be sensitive to a completely different medium in terms of ionic and protein composition are actively sought. To this end, the goal here was to discover and optimize a nanostructured system where DNA molecules would be encapsulated in nanocapsules consisting in an oily core and a shell covered by PEG stretches obtained through a nanoemulsion process in the absence of organic solvent. This encapsulation form of DNA molecules would prevent interactions with external hostile biological fluid. The results show the entrapment of lipoplexes into lipid nanocapsules, leading to the formation of neutral...

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lad01Biomaterials