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Functional PEG–peptide hydrogels to modulate local inflammation inducedby the pro-inflammatory cytokine TNFα

Hydrogels are an important class of biomaterials for cell encapsulation and delivery, providing a physical barrier or “immuno-isolation” between the host tissue and encapsulated cells. The semi-permeable gel protects the encapsulated cells from host immune cells and/or antibody recognition while all... Full description

Journal Title: Biomaterials 2009, Vol.30(28), pp.4907-4914
Main Author: Lin, Chien-Chi
Other Authors: Metters, Andrew T , Anseth, Kristi S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.05.083
Link: https://www.sciencedirect.com/science/article/pii/S014296120900605X
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2009_05_083
title: Functional PEG–peptide hydrogels to modulate local inflammation inducedby the pro-inflammatory cytokine TNFα
format: Article
creator:
  • Lin, Chien-Chi
  • Metters, Andrew T
  • Anseth, Kristi S
subjects:
  • Hydrogel
  • Inflammation
  • Cytokine
  • Apoptosis
  • Mesenchymal Stem Cells
  • Medicine
  • Engineering
ispartof: Biomaterials, 2009, Vol.30(28), pp.4907-4914
description: Hydrogels are an important class of biomaterials for cell encapsulation and delivery, providing a physical barrier or “immuno-isolation” between the host tissue and encapsulated cells. The semi-permeable gel protects the encapsulated cells from host immune cells and/or antibody recognition while allowing facile diffusion of nutrients. However, a previously un-addressed problem is that highly permissive hydrogels cannot exclude the infiltration of soluble immune-mediators, such as pro-inflammatory cytokines that are highly expressed in wounded environments . When encountered with pro-inflammatory cytokines, encapsulated cells fail to perform their desired functions. Here, we report the synthesis, characterization, and application of peptide-functionalized, cytokine-antagonizing poly(ethylene glycol) (PEG) hydrogels capable of sequestering the pro-inflammatory cytokine, tumor necrosis factor α (TNFα). Results demonstrate that the survival, function, and differentiation...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.05.083
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleFunctional PEG–peptide hydrogels to modulate local inflammation inducedby the pro-inflammatory cytokine TNFα
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subjectHydrogel ; Inflammation ; Cytokine ; Apoptosis ; Mesenchymal Stem Cells ; Medicine ; Engineering
descriptionHydrogels are an important class of biomaterials for cell encapsulation and delivery, providing a physical barrier or “immuno-isolation” between the host tissue and encapsulated cells. The semi-permeable gel protects the encapsulated cells from host immune cells and/or antibody recognition while allowing facile diffusion of nutrients. However, a previously un-addressed problem is that highly permissive hydrogels cannot exclude the infiltration of soluble immune-mediators, such as pro-inflammatory cytokines that are highly expressed in wounded environments . When encountered with pro-inflammatory cytokines, encapsulated cells fail to perform their desired functions. Here, we report the synthesis, characterization, and application of peptide-functionalized, cytokine-antagonizing poly(ethylene glycol) (PEG) hydrogels capable of sequestering the pro-inflammatory cytokine, tumor necrosis factor α (TNFα). Results demonstrate that the survival, function, and differentiation...
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Hydrogels are an important class of biomaterials for cell encapsulation and delivery, providing a physical barrier or “immuno-isolation” between the host tissue and encapsulated cells. The semi-permeable gel protects the encapsulated cells from host immune cells and/or antibody recognition while allowing facile diffusion of nutrients. However, a previously un-addressed problem is that highly permissive hydrogels cannot exclude the infiltration of soluble immune-mediators, such as pro-inflammatory cytokines that are highly expressed in wounded environments

. When encountered with pro-inflammatory cytokines, encapsulated cells fail to perform their desired functions. Here, we report the synthesis, characterization, and application of peptide-functionalized, cytokine-antagonizing poly(ethylene glycol) (PEG) hydrogels capable of sequestering the pro-inflammatory cytokine, tumor necrosis factor α (TNFα). Results demonstrate that the survival, function, and differentiation...

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