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Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery

Trimethyl chitosan-cysteine conjugate (TMC-Cys) was synthesized in an attempt to combine the mucoadhesion and the permeation enhancing effects of TMC and thiolated polymers related to different mechanisms for oral absorption. TMC-Cys with various molecular weights (30, 200, and 500 kDa) and quaterni... Full description

Journal Title: Biomaterials 2009, Vol.30(29), pp.5691-5700
Main Author: Yin, Lichen
Other Authors: Ding, Jieying , He, Chunbai , Cui, Liming , Tang, Cui , Yin, Chunhua
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.06.055
Link: https://www.sciencedirect.com/science/article/pii/S0142961209006802
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2009_06_055
title: Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
format: Article
creator:
  • Yin, Lichen
  • Ding, Jieying
  • He, Chunbai
  • Cui, Liming
  • Tang, Cui
  • Yin, Chunhua
subjects:
  • Thiolated Trimethyl Chitosan
  • Self-Assembled Nanoparticles
  • Insulin
  • Oral Delivery
  • Mucoadhesion
  • Permeation Enhancement
  • Medicine
  • Engineering
ispartof: Biomaterials, 2009, Vol.30(29), pp.5691-5700
description: Trimethyl chitosan-cysteine conjugate (TMC-Cys) was synthesized in an attempt to combine the mucoadhesion and the permeation enhancing effects of TMC and thiolated polymers related to different mechanisms for oral absorption. TMC-Cys with various molecular weights (30, 200, and 500 kDa) and quaternization degrees (15 and 30%) was allowed to form polyelectrolyte nanoparticles with insulin through self-assembly, which demonstrated particle size of 100–200 nm, zeta potential of +12 to +18 mV, and high encapsulation efficiency. TMC-Cys/insulin nanoparticles (TMC-Cys NP) showed a 2.1–4.7-fold increase in mucoadhesion compared to TMC/insulin nanoparticles (TMC NP), which might be partly attributed to disulfide formation between TMC-Cys and mucin as evidenced by DSC measurement. Compared to insulin solution and TMC NP, TMC-Cys NP induced increased insulin transport through rat intestine by 3.3–11.7 and 1.7–2.6 folds,...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.06.055
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleDrug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
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subjectThiolated Trimethyl Chitosan ; Self-Assembled Nanoparticles ; Insulin ; Oral Delivery ; Mucoadhesion ; Permeation Enhancement ; Medicine ; Engineering
descriptionTrimethyl chitosan-cysteine conjugate (TMC-Cys) was synthesized in an attempt to combine the mucoadhesion and the permeation enhancing effects of TMC and thiolated polymers related to different mechanisms for oral absorption. TMC-Cys with various molecular weights (30, 200, and 500 kDa) and quaternization degrees (15 and 30%) was allowed to form polyelectrolyte nanoparticles with insulin through self-assembly, which demonstrated particle size of 100–200 nm, zeta potential of +12 to +18 mV, and high encapsulation efficiency. TMC-Cys/insulin nanoparticles (TMC-Cys NP) showed a 2.1–4.7-fold increase in mucoadhesion compared to TMC/insulin nanoparticles (TMC NP), which might be partly attributed to disulfide formation between TMC-Cys and mucin as evidenced by DSC measurement. Compared to insulin solution and TMC NP, TMC-Cys NP induced increased insulin transport through rat intestine by 3.3–11.7 and 1.7–2.6 folds,...
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