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Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting

Systemic gene delivery systems are needed for therapeutic application to organs that are inaccessible by percutaneous injection. Currently, the main objective is the development of a stable and non-toxic vector that can encapsulate and deliver foreign genetic material to target cells. To this end, D... Full description

Journal Title: Biomaterials 2010, Vol.31(2), pp.321-329
Main Author: Morille, Marie
Other Authors: Montier, Tristan , Legras, Pierre , Carmoy, Nathalie , Brodin, Priscille , Pitard, Bruno , Benoît, Jean-Pierre , Passirani, Catherine
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.09.044
Link: http://dx.doi.org/10.1016/j.biomaterials.2009.09.044
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2009_09_044
title: Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting
format: Article
creator:
  • Morille, Marie
  • Montier, Tristan
  • Legras, Pierre
  • Carmoy, Nathalie
  • Brodin, Priscille
  • Pitard, Bruno
  • Benoît, Jean-Pierre
  • Passirani, Catherine
subjects:
  • Poly (Ethylene Glycol)
  • Non-Viral Vector
  • Stealth Properties
  • Blood Circulation
  • Tumor Accumulation
  • Enhanced Permeability and Retention Effect
  • Poly (Ethylene Glycol)
  • Non-Viral Vector
  • Stealth Properties
  • Blood Circulation
  • Tumor Accumulation
  • Enhanced Permeability and Retention Effect
  • Medicine
  • Engineering
ispartof: Biomaterials, 2010, Vol.31(2), pp.321-329
description: Systemic gene delivery systems are needed for therapeutic application to organs that are inaccessible by percutaneous injection. Currently, the main objective is the development of a stable and non-toxic vector that can encapsulate and deliver foreign genetic material to target cells. To this end, DNA, complexed with cationic lipids i.e. DOTAP/DOPE, was encapsulated into lipid nanocapsules (LNCs) leading to the formation of stable nanocarriers (DNA LNCs) with a size inferior to 130 nm. Amphiphilic and flexible poly (ethylene glycol) (PEG) polymer coatings [PEG lipid derivative (DSPE-mPEG 2000) or F108 poloxamer] at different concentrations were selected to make DNA LNCs stealthy. Some of these coated lipid nanocapsules were able to inhibit complement activation and were not phagocytised in vitro by macrophagic THP-1 cells whereas uncoated DNA LNCs accumulated in the vacuolar compartment of THP-1 cells. These results correlated with a significant increase of in vivo...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2009.09.044
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleLong-circulating DNA lipid nanocapsules as new vector for passive tumor targeting
creatorMorille, Marie ; Montier, Tristan ; Legras, Pierre ; Carmoy, Nathalie ; Brodin, Priscille ; Pitard, Bruno ; Benoît, Jean-Pierre ; Passirani, Catherine
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subjectPoly (Ethylene Glycol) ; Non-Viral Vector ; Stealth Properties ; Blood Circulation ; Tumor Accumulation ; Enhanced Permeability and Retention Effect ; Poly (Ethylene Glycol) ; Non-Viral Vector ; Stealth Properties ; Blood Circulation ; Tumor Accumulation ; Enhanced Permeability and Retention Effect ; Medicine ; Engineering
descriptionSystemic gene delivery systems are needed for therapeutic application to organs that are inaccessible by percutaneous injection. Currently, the main objective is the development of a stable and non-toxic vector that can encapsulate and deliver foreign genetic material to target cells. To this end, DNA, complexed with cationic lipids i.e. DOTAP/DOPE, was encapsulated into lipid nanocapsules (LNCs) leading to the formation of stable nanocarriers (DNA LNCs) with a size inferior to 130 nm. Amphiphilic and flexible poly (ethylene glycol) (PEG) polymer coatings [PEG lipid derivative (DSPE-mPEG 2000) or F108 poloxamer] at different concentrations were selected to make DNA LNCs stealthy. Some of these coated lipid nanocapsules were able to inhibit complement activation and were not phagocytised in vitro by macrophagic THP-1 cells whereas uncoated DNA LNCs accumulated in the vacuolar compartment of THP-1 cells. These results correlated with a significant increase of in vivo...
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Systemic gene delivery systems are needed for therapeutic application to organs that are inaccessible by percutaneous injection. Currently, the main objective is the development of a stable and non-toxic vector that can encapsulate and deliver foreign genetic material to target cells. To this end, DNA, complexed with cationic lipids i.e. DOTAP/DOPE, was encapsulated into lipid nanocapsules (LNCs) leading to the formation of stable nanocarriers (DNA LNCs) with a size inferior to 130 nm. Amphiphilic and flexible poly (ethylene glycol) (PEG) polymer coatings [PEG lipid derivative (DSPE-mPEG 2000) or F108 poloxamer] at different concentrations were selected to make DNA LNCs stealthy. Some of these coated lipid nanocapsules were able to inhibit complement activation and were not phagocytised in vitro by macrophagic THP-1 cells whereas uncoated DNA LNCs accumulated in the vacuolar compartment of THP-1 cells. These results correlated with a significant increase of in vivo...

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Systemic gene delivery systems are needed for therapeutic application to organs that are inaccessible by percutaneous injection. Currently, the main objective is the development of a stable and non-toxic vector that can encapsulate and deliver foreign genetic material to target cells. To this end, DNA, complexed with cationic lipids i.e. DOTAP/DOPE, was encapsulated into lipid nanocapsules (LNCs) leading to the formation of stable nanocarriers (DNA LNCs) with a size inferior to 130 nm. Amphiphilic and flexible poly (ethylene glycol) (PEG) polymer coatings [PEG lipid derivative (DSPE-mPEG 2000) or F108 poloxamer] at different concentrations were selected to make DNA LNCs stealthy. Some of these coated lipid nanocapsules were able to inhibit complement activation and were not phagocytised in vitro by macrophagic THP-1 cells whereas uncoated DNA LNCs accumulated in the vacuolar compartment of THP-1 cells. These results correlated with a significant increase of in vivo...

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doi10.1016/j.biomaterials.2009.09.044
lad01Biomaterials