schliessen

Filtern

 

Bibliotheken

A small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity

We introduce a new category of nanoparticle-based MRI contrast agents (CAs) by encapsulating paramagnetic chelated gadolinium(III), i.e., Gd ·DOTA, through supramolecular assembly of molecular building blocks that carry complementary molecular recognition motifs, including adamantane (Ad) and β-cycl... Full description

Journal Title: Biomaterials March 2011, Vol.32(8), pp.2160-2165
Main Author: Chen, Kuan-Ju
Other Authors: Wolahan, Stephanie M , Wang, Hao , Hsu, Chao-Hsiung , Chang, Hsing-Wei , Durazo, Armando , Hwang, Lian-Pin , Garcia, Mitch A , Jiang, Ziyue K , Wu, Lily , Lin, Yung-Ya , Tseng, Hsian-Rong
Format: Electronic Article Electronic Article
Language: English
Subjects:
Mri
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2010.11.043
Link: https://www.sciencedirect.com/science/article/pii/S0142961210014821
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_biomaterials_2010_11_043
title: A small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity
format: Article
creator:
  • Chen, Kuan-Ju
  • Wolahan, Stephanie M
  • Wang, Hao
  • Hsu, Chao-Hsiung
  • Chang, Hsing-Wei
  • Durazo, Armando
  • Hwang, Lian-Pin
  • Garcia, Mitch A
  • Jiang, Ziyue K
  • Wu, Lily
  • Lin, Yung-Ya
  • Tseng, Hsian-Rong
subjects:
  • Supramolecular Chemistry
  • Cyclodextrin
  • T1-Weighted Contrast Agent
  • Mri
  • Gadolinium
  • Dynamic Imaging
  • Medicine
  • Engineering
ispartof: Biomaterials, March 2011, Vol.32(8), pp.2160-2165
description: We introduce a new category of nanoparticle-based MRI contrast agents (CAs) by encapsulating paramagnetic chelated gadolinium(III), i.e., Gd ·DOTA, through supramolecular assembly of molecular building blocks that carry complementary molecular recognition motifs, including adamantane (Ad) and β-cyclodextrin (CD). A small library of Gd ·DOTA-encapsulated supramolecular nanoparticles (Gd ·DOTA⊂SNPs) was produced by systematically altering the molecular building block mixing ratios. A broad spectrum of relaxation rates was correlated to the resulting Gd ·DOTA⊂SNP library. Consequently, an optimal synthetic formulation of Gd ·DOTA⊂SNPs with an of 17.3 s  mM (ca. 4-fold higher than clinical Gd chelated complexes at high field strengths) was identified. -weighted imaging of Gd ·DOTA⊂SNPs exhibits an enhanced sensitivity with a contrast-to-noise ratio (C/N ratio) ca. 3.6 times greater than that observed for free Gd ·DTPA. A Gd ·DOTA⊂SNPs solution was injected into foot pads of mice, and MRI was employed to monitor dynamic lymphatic drainage of the Gd ·DOTA⊂SNPs-based CA. We observe an increase in signal intensity of the brachial lymph node in -weighted imaging after injecting Gd ·DOTA⊂SNPs but not after injecting Gd ·DTPA. The MRI results are supported by ICP-MS analysis . These results show that Gd ·DOTA⊂SNPs not only exhibits enhanced relaxivity and high sensitivity but also can serve as a potential tool for diagnosis of cancer metastasis.
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2010.11.043
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


@attributes
ID1339800316
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_biomaterials_2010_11_043
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_biomaterials_2010_11_043
sourcesystemOther
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
pqid1671427302
galeid302503659
display
typearticle
titleA small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity
creatorChen, Kuan-Ju ; Wolahan, Stephanie M ; Wang, Hao ; Hsu, Chao-Hsiung ; Chang, Hsing-Wei ; Durazo, Armando ; Hwang, Lian-Pin ; Garcia, Mitch A ; Jiang, Ziyue K ; Wu, Lily ; Lin, Yung-Ya ; Tseng, Hsian-Rong
ispartofBiomaterials, March 2011, Vol.32(8), pp.2160-2165
identifier
subjectSupramolecular Chemistry ; Cyclodextrin ; T1-Weighted Contrast Agent ; Mri ; Gadolinium ; Dynamic Imaging ; Medicine ; Engineering
descriptionWe introduce a new category of nanoparticle-based MRI contrast agents (CAs) by encapsulating paramagnetic chelated gadolinium(III), i.e., Gd ·DOTA, through supramolecular assembly of molecular building blocks that carry complementary molecular recognition motifs, including adamantane (Ad) and β-cyclodextrin (CD). A small library of Gd ·DOTA-encapsulated supramolecular nanoparticles (Gd ·DOTA⊂SNPs) was produced by systematically altering the molecular building block mixing ratios. A broad spectrum of relaxation rates was correlated to the resulting Gd ·DOTA⊂SNP library. Consequently, an optimal synthetic formulation of Gd ·DOTA⊂SNPs with an of 17.3 s  mM (ca. 4-fold higher than clinical Gd chelated complexes at high field strengths) was identified. -weighted imaging of Gd ·DOTA⊂SNPs exhibits an enhanced sensitivity with a contrast-to-noise ratio (C/N ratio) ca. 3.6 times greater than that observed for free Gd ·DTPA. A Gd ·DOTA⊂SNPs solution was injected into foot pads of mice, and MRI was employed to monitor dynamic lymphatic drainage of the Gd ·DOTA⊂SNPs-based CA. We observe an increase in signal intensity of the brachial lymph node in -weighted imaging after injecting Gd ·DOTA⊂SNPs but not after injecting Gd ·DTPA. The MRI results are supported by ICP-MS analysis . These results show that Gd ·DOTA⊂SNPs not only exhibits enhanced relaxivity and high sensitivity but also can serve as a potential tool for diagnosis of cancer metastasis.
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961210014821$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Chen, Kuan-Ju
1Wolahan, Stephanie M
2Wang, Hao
3Hsu, Chao-Hsiung
4Chang, Hsing-Wei
5Durazo, Armando
6Hwang, Lian-Pin
7Garcia, Mitch A
8Jiang, Ziyue K
9Wu, Lily
10Lin, Yung-Ya
11Tseng, Hsian-Rong
titleA small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity
description
subject
0Supramolecular Chemistry
1Cyclodextrin
2T1-Weighted Contrast Agent
3Mri
4Gadolinium
5Dynamic Imaging
6Medicine
7Engineering
general
0English
1Elsevier Ltd
210.1016/j.biomaterials.2010.11.043
3ScienceDirect (Elsevier B.V.)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_biomaterials_2010_11_043
issn
00142-9612
101429612
21878-5905
318785905
rsrctypearticle
creationdate2011
addtitleBiomaterials
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
startdate20110301
enddate20110331
lsr40Biomaterials, March 2011, Vol.32 (8), pp.2160-2165
doi10.1016/j.biomaterials.2010.11.043
citationpf 2160 pt 2165 vol 32 issue 8
lsr30VSR-Enriched:[pqid, galeid]
sort
titleA small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity
authorChen, Kuan-Ju ; Wolahan, Stephanie M ; Wang, Hao ; Hsu, Chao-Hsiung ; Chang, Hsing-Wei ; Durazo, Armando ; Hwang, Lian-Pin ; Garcia, Mitch A ; Jiang, Ziyue K ; Wu, Lily ; Lin, Yung-Ya ; Tseng, Hsian-Rong
creationdate20110300
lso0120110300
facets
frbrgroupid5302803983613119193
frbrtype5
newrecords20190904
languageeng
topic
0Supramolecular Chemistry
1Cyclodextrin
2T1-Weighted Contrast Agent
3Mri
4Gadolinium
5Dynamic Imaging
6Medicine
7Engineering
collectionScienceDirect (Elsevier B.V.)
prefilterarticles
rsrctypearticles
creatorcontrib
0Chen, Kuan-Ju
1Wolahan, Stephanie M
2Wang, Hao
3Hsu, Chao-Hsiung
4Chang, Hsing-Wei
5Durazo, Armando
6Hwang, Lian-Pin
7Garcia, Mitch A
8Jiang, Ziyue K
9Wu, Lily
10Lin, Yung-Ya
11Tseng, Hsian-Rong
jtitleBiomaterials
creationdate2011
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Chen
1Wolahan
2Wang
3Hsu
4Chang
5Durazo
6Hwang
7Garcia
8Jiang
9Wu
10Lin
11Tseng
aufirst
0Kuan-Ju
1Stephanie M
2Hao
3Chao-Hsiung
4Hsing-Wei
5Armando
6Lian-Pin
7Mitch A
8Ziyue K
9Lily
10Yung-Ya
11Hsian-Rong
auinitK
auinit1K
au
0Chen, Kuan-Ju
1Wolahan, Stephanie M
2Wang, Hao
3Hsu, Chao-Hsiung
4Chang, Hsing-Wei
5Durazo, Armando
6Hwang, Lian-Pin
7Garcia, Mitch A
8Jiang, Ziyue K
9Wu, Lily
10Lin, Yung-Ya
11Tseng, Hsian-Rong
atitleA small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity
jtitleBiomaterials
risdate201103
volume32
issue8
spage2160
epage2165
pages2160-2165
issn0142-9612
eissn1878-5905
formatjournal
genrearticle
ristypeJOUR
abstract
pubElsevier Ltd
doi10.1016/j.biomaterials.2010.11.043
lad01Biomaterials
date2011-03