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Chondrogenesis of mesenchymal stem cells and dedifferentiated chondrocytes by transfection with SOX Trio genes

In this study, bone marrow-derived mesenchymal stem cells (MSCs), adipose-derived mesenchymal stem cells (ASCs) and dedifferentiated chondrocytes were transfected with SOX5, 6, and 9 genes (SOX Trio) and grown under pellet culture conditions (encapsulated in a fibrin hydrogel) to evaluate the chondr... Full description

Journal Title: Biomaterials October 2011, Vol.32(30), pp.7695-7704
Main Author: Yang, Han Na
Other Authors: Park, Ji Sun , Woo, Dae Gyun , Jeon, Su Yeon , Do, Hyun-Jin , Lim, Hye-Young , Kim, Seung Who , Kim, Jae-Hwan , Park, Keun-Hong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2011.06.059
Link: https://www.sciencedirect.com/science/article/pii/S0142961211007393
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2011_06_059
title: Chondrogenesis of mesenchymal stem cells and dedifferentiated chondrocytes by transfection with SOX Trio genes
format: Article
creator:
  • Yang, Han Na
  • Park, Ji Sun
  • Woo, Dae Gyun
  • Jeon, Su Yeon
  • Do, Hyun-Jin
  • Lim, Hye-Young
  • Kim, Seung Who
  • Kim, Jae-Hwan
  • Park, Keun-Hong
subjects:
  • Fibrin
  • Hmsc
  • Sox Trio
  • Chondrogenesis
  • Matured Chondrocytes
  • Medicine
  • Engineering
ispartof: Biomaterials, October 2011, Vol.32(30), pp.7695-7704
description: In this study, bone marrow-derived mesenchymal stem cells (MSCs), adipose-derived mesenchymal stem cells (ASCs) and dedifferentiated chondrocytes were transfected with SOX5, 6, and 9 genes (SOX Trio) and grown under pellet culture conditions (encapsulated in a fibrin hydrogel) to evaluate the chondrogenic potential and . RT-PCR, real-time quantitative PCR (qPCR), histology, and immunohistochemical assays were performed to determine the chondrogenic potential of the stem cells and dedifferentiated chondrocytes. Chondrogenic genes and proteins were more highly expressed in SOX Trio-expressing cells than in untransfected cells. In addition, not only specific genes and proteins, but cartilage-forming tissues were observed in nude mice transplanted with fibrin hydrogel encapsulated SOX Trio-expressing MSCs, ASCs, and dedifferentiated chondrocytes. Both and analyses revealed that fibrin hydrogel encapsulated...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2011.06.059
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleChondrogenesis of mesenchymal stem cells and dedifferentiated chondrocytes by transfection with SOX Trio genes
creatorYang, Han Na ; Park, Ji Sun ; Woo, Dae Gyun ; Jeon, Su Yeon ; Do, Hyun-Jin ; Lim, Hye-Young ; Kim, Seung Who ; Kim, Jae-Hwan ; Park, Keun-Hong
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subjectFibrin ; Hmsc ; Sox Trio ; Chondrogenesis ; Matured Chondrocytes ; Medicine ; Engineering
descriptionIn this study, bone marrow-derived mesenchymal stem cells (MSCs), adipose-derived mesenchymal stem cells (ASCs) and dedifferentiated chondrocytes were transfected with SOX5, 6, and 9 genes (SOX Trio) and grown under pellet culture conditions (encapsulated in a fibrin hydrogel) to evaluate the chondrogenic potential and . RT-PCR, real-time quantitative PCR (qPCR), histology, and immunohistochemical assays were performed to determine the chondrogenic potential of the stem cells and dedifferentiated chondrocytes. Chondrogenic genes and proteins were more highly expressed in SOX Trio-expressing cells than in untransfected cells. In addition, not only specific genes and proteins, but cartilage-forming tissues were observed in nude mice transplanted with fibrin hydrogel encapsulated SOX Trio-expressing MSCs, ASCs, and dedifferentiated chondrocytes. Both and analyses revealed that fibrin hydrogel encapsulated...
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