schliessen

Filtern

 

Bibliotheken

Rapamycin encapsulated in dual-responsive micelles for cancer therapy

Rapamycin has been developed as a potential anticancer drug for treatment in rapamycin-sensitive cancer models, but its poor water solubility greatly hampers the application to cancer therapy. This study investigated the preparation, release profiles, uptake and / study of a dual-responsive micellar... Full description

Journal Title: Biomaterials January 2013, Vol.34(4), pp.1115-1127
Main Author: Chen, Yi-Chun
Other Authors: Lo, Chun-Liang , Lin, Yu-Fen , Hsiue, Ging-Ho
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2012.10.034
Link: https://www.sciencedirect.com/science/article/pii/S0142961212011556
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_biomaterials_2012_10_034
title: Rapamycin encapsulated in dual-responsive micelles for cancer therapy
format: Article
creator:
  • Chen, Yi-Chun
  • Lo, Chun-Liang
  • Lin, Yu-Fen
  • Hsiue, Ging-Ho
subjects:
  • Polymeric Micelles
  • Ph-Responsive
  • Rapamycin
  • Autophagy
  • Intracellular Drug Delivery
  • Medicine
  • Engineering
ispartof: Biomaterials, January 2013, Vol.34(4), pp.1115-1127
description: Rapamycin has been developed as a potential anticancer drug for treatment in rapamycin-sensitive cancer models, but its poor water solubility greatly hampers the application to cancer therapy. This study investigated the preparation, release profiles, uptake and / study of a dual-responsive micellar formulation of rapamycin. Rapamycin-loaded micelles (rapa-micelles) measured approximately ca. 150 nm with narrow size distribution and high stability in bovine serum albumin solution. It was shown that rapamycin could be loaded efficiently in mixed micelles up to a concentration of 1.8 mg/mL by a hot shock protocol. Rapamycin release kinetic studies demonstrated that this type of micellar system could be applied in physiological conditions under varied pH environments. Confocal and pH-topography imaging revealed a clear distribution of rapa-micelles, and visible intracellular pH changes which induced encapsulated rapamycin to be released and then induced autophagolysosome formation. tumor growth inhibition showed that rapa-micelles exhibited excellent antitumor activity and a high rate of apoptosis in HCT116 cancer cells. These results indicated that dual-responsive mixed micelles provided a suitable delivery system for the parenteral administration of drugs with poor water solubility, such as rapamycin, in cancer therapy.
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2012.10.034
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


@attributes
ID619213504
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_biomaterials_2012_10_034
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_biomaterials_2012_10_034
sourcesystemOther
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
pqid1664201322
galeid310714756
display
typearticle
titleRapamycin encapsulated in dual-responsive micelles for cancer therapy
creatorChen, Yi-Chun ; Lo, Chun-Liang ; Lin, Yu-Fen ; Hsiue, Ging-Ho
ispartofBiomaterials, January 2013, Vol.34(4), pp.1115-1127
identifier
subjectPolymeric Micelles ; Ph-Responsive ; Rapamycin ; Autophagy ; Intracellular Drug Delivery ; Medicine ; Engineering
descriptionRapamycin has been developed as a potential anticancer drug for treatment in rapamycin-sensitive cancer models, but its poor water solubility greatly hampers the application to cancer therapy. This study investigated the preparation, release profiles, uptake and / study of a dual-responsive micellar formulation of rapamycin. Rapamycin-loaded micelles (rapa-micelles) measured approximately ca. 150 nm with narrow size distribution and high stability in bovine serum albumin solution. It was shown that rapamycin could be loaded efficiently in mixed micelles up to a concentration of 1.8 mg/mL by a hot shock protocol. Rapamycin release kinetic studies demonstrated that this type of micellar system could be applied in physiological conditions under varied pH environments. Confocal and pH-topography imaging revealed a clear distribution of rapa-micelles, and visible intracellular pH changes which induced encapsulated rapamycin to be released and then induced autophagolysosome formation. tumor growth inhibition showed that rapa-micelles exhibited excellent antitumor activity and a high rate of apoptosis in HCT116 cancer cells. These results indicated that dual-responsive mixed micelles provided a suitable delivery system for the parenteral administration of drugs with poor water solubility, such as rapamycin, in cancer therapy.
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961212011556$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Chen, Yi-Chun
1Lo, Chun-Liang
2Lin, Yu-Fen
3Hsiue, Ging-Ho
titleRapamycin encapsulated in dual-responsive micelles for cancer therapy
description
subject
0Polymeric Micelles
1Ph-Responsive
2Rapamycin
3Autophagy
4Intracellular Drug Delivery
5Medicine
6Engineering
general
0English
1Elsevier Ltd
210.1016/j.biomaterials.2012.10.034
3ScienceDirect (Elsevier B.V.)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_biomaterials_2012_10_034
issn
00142-9612
101429612
21878-5905
318785905
rsrctypearticle
creationdate2013
addtitleBiomaterials
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
startdate20130101
enddate20130131
lsr40Biomaterials, January 2013, Vol.34 (4), pp.1115-1127
doi10.1016/j.biomaterials.2012.10.034
citationpf 1115 pt 1127 vol 34 issue 4
lsr30VSR-Enriched:[galeid, pqid]
sort
titleRapamycin encapsulated in dual-responsive micelles for cancer therapy
authorChen, Yi-Chun ; Lo, Chun-Liang ; Lin, Yu-Fen ; Hsiue, Ging-Ho
creationdate20130100
lso0120130100
facets
frbrgroupid5701223523015553649
frbrtype5
newrecords20190904
languageeng
topic
0Polymeric Micelles
1Ph-Responsive
2Rapamycin
3Autophagy
4Intracellular Drug Delivery
5Medicine
6Engineering
collectionScienceDirect (Elsevier B.V.)
prefilterarticles
rsrctypearticles
creatorcontrib
0Chen, Yi-Chun
1Lo, Chun-Liang
2Lin, Yu-Fen
3Hsiue, Ging-Ho
jtitleBiomaterials
creationdate2013
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Chen
1Lo
2Lin
3Hsiue
aufirst
0Yi-Chun
1Chun-Liang
2Yu-Fen
3Ging-Ho
auinitY
auinit1Y
au
0Chen, Yi-Chun
1Lo, Chun-Liang
2Lin, Yu-Fen
3Hsiue, Ging-Ho
atitleRapamycin encapsulated in dual-responsive micelles for cancer therapy
jtitleBiomaterials
risdate201301
volume34
issue4
spage1115
epage1127
pages1115-1127
issn0142-9612
eissn1878-5905
formatjournal
genrearticle
ristypeJOUR
abstract
pubElsevier Ltd
doi10.1016/j.biomaterials.2012.10.034
lad01Biomaterials
date2013-01