schliessen

Filtern

 

Bibliotheken

Galactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages

Galactosylated trimethyl chitosan–cysteine (GTC) nanoparticles (NPs) were developed for oral delivery of a ( ) siRNA (si ) to the activated macrophages for treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). siRNA loaded GTC NPs were prepared based on ionic gelation of GTC wit... Full description

Journal Title: Biomaterials May 2013, Vol.34(14), pp.3667-3677
Main Author: Zhang, Jing
Other Authors: Tang, Cui , Yin, Chunhua
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.01.079
Link: https://www.sciencedirect.com/science/article/pii/S0142961213001348
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_biomaterials_2013_01_079
title: Galactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages
format: Article
creator:
  • Zhang, Jing
  • Tang, Cui
  • Yin, Chunhua
subjects:
  • Chitosan Derivate Nanoparticles
  • Galactosylated Modification
  • Sirna
  • Oral Administration
  • Ulcerative Colitis
  • Targeted Gene Delivery
  • Medicine
  • Engineering
ispartof: Biomaterials, May 2013, Vol.34(14), pp.3667-3677
description: Galactosylated trimethyl chitosan–cysteine (GTC) nanoparticles (NPs) were developed for oral delivery of a ( ) siRNA (si ) to the activated macrophages for treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). siRNA loaded GTC NPs were prepared based on ionic gelation of GTC with anionic crosslinkers (tripolyphosphate (TPP) or hyaluronic acid (HA)). The types of crosslinkers involved in GTC NPs significantly affected their physicochemical characteristics. GTC/TPP NPs with smaller particle size and lower zeta potential possessed superior structural stability in gastrointestinal environment compared to GTC/HA NPs. Cellular uptake of GTC/TPP NPs in activated macrophages was significantly enhanced compared to trimethyl chitosan-cysteine (TC)/TPP NPs owing to galactose receptor-mediated endocytosis. The and gene knockdown measurement showed that si ...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.01.079
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


@attributes
ID1381389793
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_biomaterials_2013_01_079
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_biomaterials_2013_01_079
sourcesystemPC
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
pqid1314704883
galeid321160872
display
typearticle
titleGalactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages
creatorZhang, Jing ; Tang, Cui ; Yin, Chunhua
ispartofBiomaterials, May 2013, Vol.34(14), pp.3667-3677
identifier
subjectChitosan Derivate Nanoparticles ; Galactosylated Modification ; Sirna ; Oral Administration ; Ulcerative Colitis ; Targeted Gene Delivery ; Medicine ; Engineering
descriptionGalactosylated trimethyl chitosan–cysteine (GTC) nanoparticles (NPs) were developed for oral delivery of a ( ) siRNA (si ) to the activated macrophages for treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). siRNA loaded GTC NPs were prepared based on ionic gelation of GTC with anionic crosslinkers (tripolyphosphate (TPP) or hyaluronic acid (HA)). The types of crosslinkers involved in GTC NPs significantly affected their physicochemical characteristics. GTC/TPP NPs with smaller particle size and lower zeta potential possessed superior structural stability in gastrointestinal environment compared to GTC/HA NPs. Cellular uptake of GTC/TPP NPs in activated macrophages was significantly enhanced compared to trimethyl chitosan-cysteine (TC)/TPP NPs owing to galactose receptor-mediated endocytosis. The and gene knockdown measurement showed that si ...
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961213001348$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Zhang, Jing
1Tang, Cui
2Yin, Chunhua
titleGalactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages
description
subject
0Chitosan Derivate Nanoparticles
1Galactosylated Modification
2Sirna
3Oral Administration
4Ulcerative Colitis
5Targeted Gene Delivery
6Medicine
7Engineering
general
0English
1Elsevier Ltd
210.1016/j.biomaterials.2013.01.079
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_biomaterials_2013_01_079
issn
00142-9612
101429612
21878-5905
318785905
rsrctypearticle
creationdate2013
addtitleBiomaterials
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
startdate20130501
enddate20130531
lsr40Biomaterials, May 2013, Vol.34 (14), pp.3667-3677
doi10.1016/j.biomaterials.2013.01.079
citationpf 3667 pt 3677 vol 34 issue 14
lsr30VSR-Enriched:[galeid, pqid]
sort
titleGalactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages
authorZhang, Jing ; Tang, Cui ; Yin, Chunhua
creationdate20130500
lso0120130500
facets
frbrgroupid560059456845297226
frbrtype5
newrecords20190904
languageeng
topic
0Chitosan Derivate Nanoparticles
1Galactosylated Modification
2Sirna
3Oral Administration
4Ulcerative Colitis
5Targeted Gene Delivery
6Medicine
7Engineering
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhang, Jing
1Tang, Cui
2Yin, Chunhua
jtitleBiomaterials
creationdate2013
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Zhang
1Tang
2Yin
aufirst
0Jing
1Cui
2Chunhua
auinitJ
auinit1J
au
0Zhang, Jing
1Tang, Cui
2Yin, Chunhua
atitleGalactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages
jtitleBiomaterials
risdate201305
volume34
issue14
spage3667
epage3677
pages3667-3677
issn0142-9612
eissn1878-5905
formatjournal
genrearticle
ristypeJOUR
abstract
pubElsevier Ltd
doi10.1016/j.biomaterials.2013.01.079
lad01Biomaterials
date2013-05