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A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

A biodegradable gel-forming controlled drug delivery system composed of curcumin loaded micelles and thermosensitive hydrogel was prepared and applied for cutaneous wound repair. Curcumin is believed to be a potent antioxidant and anti-inflammatory agent. Due to its high hydrophobicity, curcumin was... Full description

Journal Title: Biomaterials September 2013, Vol.34(27), pp.6377-6387
Main Author: Gong, Changyang
Other Authors: Wu, Qinjie , Wang, Yujun , Zhang, Doudou , Luo, Feng , Zhao, Xia , Wei, Yuquan , Qian, Zhiyong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.05.005
Link: https://www.sciencedirect.com/science/article/pii/S0142961213005590
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2013_05_005
title: A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing
format: Article
creator:
  • Gong, Changyang
  • Wu, Qinjie
  • Wang, Yujun
  • Zhang, Doudou
  • Luo, Feng
  • Zhao, Xia
  • Wei, Yuquan
  • Qian, Zhiyong
subjects:
  • Curcumin
  • Micelles
  • Thermosenstitive Hydrogel
  • Dermal Wound Healing
  • Poly(Ethylene Glycol)
  • Poly(Ɛ-Caprolactone)
  • Medicine
  • Engineering
ispartof: Biomaterials, September 2013, Vol.34(27), pp.6377-6387
description: A biodegradable gel-forming controlled drug delivery system composed of curcumin loaded micelles and thermosensitive hydrogel was prepared and applied for cutaneous wound repair. Curcumin is believed to be a potent antioxidant and anti-inflammatory agent. Due to its high hydrophobicity, curcumin was encapsulated in polymeric micelles (Cur–M) with high drug loading and encapsulation efficiency. Cur–M loaded thermosensitive hydrogel (Cur–M–H) was prepared and applied as wound dressing to enhance the cutaneous wound healing. Cur–M–H was a free-flowing sol at ambient temperature and instantly converted into a non-flowing gel at body temperature. studies suggested that Cur–M–H exhibited well tissue adhesiveness and could release curcumin in an extended period. Furthermore, linear incision and full-thickness excision wound models were employed to evaluate the wound healing activity of Cur–M–H. In incision model, Cur–M–H-treated group showed higher tensile strength and thicker epidermis. In excision model, Cur–M–H group exhibited enhancement of wound closure. Besides, in both models, Cur–M–H-treated groups showed higher collagen content, better granulation, higher wound maturity, dramatic decrease in superoxide dismutase, and slight increase in catalase. Histopathologic examination also implied that Cur–M–H could enhance cutaneous wound repair. In conclusion, biodegradable Cur–M–H composite might have great application for wound healing.
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.05.005
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleA biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing
creatorGong, Changyang ; Wu, Qinjie ; Wang, Yujun ; Zhang, Doudou ; Luo, Feng ; Zhao, Xia ; Wei, Yuquan ; Qian, Zhiyong
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subjectCurcumin ; Micelles ; Thermosenstitive Hydrogel ; Dermal Wound Healing ; Poly(Ethylene Glycol) ; Poly(Ɛ-Caprolactone) ; Medicine ; Engineering
descriptionA biodegradable gel-forming controlled drug delivery system composed of curcumin loaded micelles and thermosensitive hydrogel was prepared and applied for cutaneous wound repair. Curcumin is believed to be a potent antioxidant and anti-inflammatory agent. Due to its high hydrophobicity, curcumin was encapsulated in polymeric micelles (Cur–M) with high drug loading and encapsulation efficiency. Cur–M loaded thermosensitive hydrogel (Cur–M–H) was prepared and applied as wound dressing to enhance the cutaneous wound healing. Cur–M–H was a free-flowing sol at ambient temperature and instantly converted into a non-flowing gel at body temperature. studies suggested that Cur–M–H exhibited well tissue adhesiveness and could release curcumin in an extended period. Furthermore, linear incision and full-thickness excision wound models were employed to evaluate the wound healing activity of Cur–M–H. In incision model, Cur–M–H-treated group showed higher tensile strength and thicker epidermis. In excision model, Cur–M–H group exhibited enhancement of wound closure. Besides, in both models, Cur–M–H-treated groups showed higher collagen content, better granulation, higher wound maturity, dramatic decrease in superoxide dismutase, and slight increase in catalase. Histopathologic examination also implied that Cur–M–H could enhance cutaneous wound repair. In conclusion, biodegradable Cur–M–H composite might have great application for wound healing.
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