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Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery

Hypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole deri... Full description

Journal Title: Biomaterials February 2014, Vol.35(5), pp.1735-1743
Main Author: Thambi, Thavasyappan
Other Authors: Deepagan, V.G , Yoon, Hong Yeol , Han, Hwa Seung , Kim, Seol-Hee , Son, Soyoung , Jo, Dong-Gyu , Ahn, Cheol-Hee , Suh, Yung Doug , Kim, Kwangmeyung , Chan Kwon, Ick , Lee, Doo Sung , Park, Jae Hyung
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.11.022
Link: https://www.sciencedirect.com/science/article/pii/S0142961213013756
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2013_11_022
title: Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery
format: Article
creator:
  • Thambi, Thavasyappan
  • Deepagan, V.G
  • Yoon, Hong Yeol
  • Han, Hwa Seung
  • Kim, Seol-Hee
  • Son, Soyoung
  • Jo, Dong-Gyu
  • Ahn, Cheol-Hee
  • Suh, Yung Doug
  • Kim, Kwangmeyung
  • Chan Kwon, Ick
  • Lee, Doo Sung
  • Park, Jae Hyung
subjects:
  • Hypoxia
  • Nanoparticles
  • 2-Nitroimidazole
  • Bioreduction
  • Drug Delivery
  • Medicine
  • Engineering
ispartof: Biomaterials, February 2014, Vol.35(5), pp.1735-1743
description: Hypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate remarkably increased under the hypoxic condition. From cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions. biodistribution study demonstrated that HR-NPs were selectively accumulated...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2013.11.022
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleHypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery
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subjectHypoxia ; Nanoparticles ; 2-Nitroimidazole ; Bioreduction ; Drug Delivery ; Medicine ; Engineering
descriptionHypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate remarkably increased under the hypoxic condition. From cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions. biodistribution study demonstrated that HR-NPs were selectively accumulated...
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Hypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate remarkably increased under the hypoxic condition. From

cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions.

biodistribution study demonstrated that HR-NPs were selectively accumulated...

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abstract

Hypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate remarkably increased under the hypoxic condition. From

cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions.

biodistribution study demonstrated that HR-NPs were selectively accumulated...

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doi10.1016/j.biomaterials.2013.11.022
lad01Biomaterials
date2014-02