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The effect of simvastatin on chemotactic capability of SDF-1α and the promotion of bone regeneration

The purpose of this study was to investigate the cooperative effects of simvastatin (SIM) and stromal cell-derived factor-1α (SDF-1α) on the osteogenic and migration capabilities of mesenchymal stem cells (MSCs), and construct a cell-free bone tissue engineering system comprising SIM, SDF-1α and sca... Full description

Journal Title: Biomaterials May 2014, Vol.35(15), pp.4489-4498
Main Author: Liu, Yun-Song
Other Authors: Ou, Meng-En , Liu, Hao , Gu, Ming , Lv, Long-Wei , Fan, Cong , Chen, Tong , Zhao, Xiang-Hui , Jin, Chan-Yuan , Zhang, Xiao , Ding, Yun , Zhou, Yong-Sheng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2014.02.025
Link: https://www.sciencedirect.com/science/article/pii/S0142961214001653
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2014_02_025
title: The effect of simvastatin on chemotactic capability of SDF-1α and the promotion of bone regeneration
format: Article
creator:
  • Liu, Yun-Song
  • Ou, Meng-En
  • Liu, Hao
  • Gu, Ming
  • Lv, Long-Wei
  • Fan, Cong
  • Chen, Tong
  • Zhao, Xiang-Hui
  • Jin, Chan-Yuan
  • Zhang, Xiao
  • Ding, Yun
  • Zhou, Yong-Sheng
subjects:
  • Simvastatin
  • Stromal Cell-Derived Factor 1
  • Bone Healing
  • Cell Homing
  • Medicine
  • Engineering
ispartof: Biomaterials, May 2014, Vol.35(15), pp.4489-4498
description: The purpose of this study was to investigate the cooperative effects of simvastatin (SIM) and stromal cell-derived factor-1α (SDF-1α) on the osteogenic and migration capabilities of mesenchymal stem cells (MSCs), and construct a cell-free bone tissue engineering system comprising SIM, SDF-1α and scaffold. We found that 0.2 μ SIM significantly increased alkaline phosphatase activity (  
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2014.02.025
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleThe effect of simvastatin on chemotactic capability of SDF-1α and the promotion of bone regeneration
creatorLiu, Yun-Song ; Ou, Meng-En ; Liu, Hao ; Gu, Ming ; Lv, Long-Wei ; Fan, Cong ; Chen, Tong ; Zhao, Xiang-Hui ; Jin, Chan-Yuan ; Zhang, Xiao ; Ding, Yun ; Zhou, Yong-Sheng
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subjectSimvastatin ; Stromal Cell-Derived Factor 1 ; Bone Healing ; Cell Homing ; Medicine ; Engineering
descriptionThe purpose of this study was to investigate the cooperative effects of simvastatin (SIM) and stromal cell-derived factor-1α (SDF-1α) on the osteogenic and migration capabilities of mesenchymal stem cells (MSCs), and construct a cell-free bone tissue engineering system comprising SIM, SDF-1α and scaffold. We found that 0.2 μ SIM significantly increased alkaline phosphatase activity (  < 0.05) of mouse bone marrow MSCs with no inhibition of cell proliferation, and enhanced the chemotactic capability of SDF-1α (  < 0.05). Next, we constructed a novel cell-free bone tissue engineering system using PLGA loaded with SIM and SDF-1α, and applied it in critical-sized calvarial defects in mice. New bone formation in the defect was evaluated by micro-CT, HE staining and immunohistochemistry. The results showed that PLGA loaded with SIM and SDF-1α promoted bone regeneration significantly more than controls. We investigated possible...
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