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Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart

Cell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate if acute retention can be improved with a biomaterial carrier. Cells were quant... Full description

Journal Title: Biomaterials August 2014, Vol.35(25), pp.6850-6858
Main Author: Roche, Ellen T
Other Authors: Hastings, Conn L , Lewin, Sarah A , Shvartsman, Dmitry E , Brudno, Yevgeny , Vasilyev, Nikolay V , O'Brien, Fergal J , Walsh, Conor J , Duffy, Garry P , Mooney, David J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2014.04.114
Link: https://www.sciencedirect.com/science/article/pii/S0142961214005274
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2014_04_114
title: Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart
format: Article
creator:
  • Roche, Ellen T
  • Hastings, Conn L
  • Lewin, Sarah A
  • Shvartsman, Dmitry E
  • Brudno, Yevgeny
  • Vasilyev, Nikolay V
  • O'Brien, Fergal J
  • Walsh, Conor J
  • Duffy, Garry P
  • Mooney, David J
subjects:
  • Alginate
  • Collagen
  • Cell Viability
  • Heart
  • Hydrogel
  • Medicine
  • Engineering
ispartof: Biomaterials, August 2014, Vol.35(25), pp.6850-6858
description: Cell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate if acute retention can be improved with a biomaterial carrier. Cells were quantified post-implantation in a rat myocardial infarct model in five groups (  = 7–8); saline injection (current clinical standard), two injectable hydrogels (alginate, chitosan/β-glycerophosphate (chitosan/ß-GP)) and two epicardial patches (alginate, collagen). Human mesenchymal stem cells (hMSCs) were delivered to the infarct border zone with each biomaterial. At 24 h, retained cells were quantified by fluorescence. All biomaterials produced superior fluorescence to saline control, with approximately 8- and 14-fold increases with alginate and chitosan/β-GP injectables, and 47 and 59-fold increases achieved with collagen and alginate patches, respectively. Immunohistochemical...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2014.04.114
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleComparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart
creatorRoche, Ellen T ; Hastings, Conn L ; Lewin, Sarah A ; Shvartsman, Dmitry E ; Brudno, Yevgeny ; Vasilyev, Nikolay V ; O'Brien, Fergal J ; Walsh, Conor J ; Duffy, Garry P ; Mooney, David J
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subjectAlginate ; Collagen ; Cell Viability ; Heart ; Hydrogel ; Medicine ; Engineering
descriptionCell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate if acute retention can be improved with a biomaterial carrier. Cells were quantified post-implantation in a rat myocardial infarct model in five groups (  = 7–8); saline injection (current clinical standard), two injectable hydrogels (alginate, chitosan/β-glycerophosphate (chitosan/ß-GP)) and two epicardial patches (alginate, collagen). Human mesenchymal stem cells (hMSCs) were delivered to the infarct border zone with each biomaterial. At 24 h, retained cells were quantified by fluorescence. All biomaterials produced superior fluorescence to saline control, with approximately 8- and 14-fold increases with alginate and chitosan/β-GP injectables, and 47 and 59-fold increases achieved with collagen and alginate patches, respectively. Immunohistochemical...
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titleComparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart
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Cell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate if acute retention can be improved with a biomaterial carrier. Cells were quantified post-implantation in a rat myocardial infarct model in five groups (

 = 7–8); saline injection (current clinical standard), two injectable hydrogels (alginate, chitosan/β-glycerophosphate (chitosan/ß-GP)) and two epicardial patches (alginate, collagen). Human mesenchymal stem cells (hMSCs) were delivered to the infarct border zone with each biomaterial. At 24 h, retained cells were quantified by fluorescence. All biomaterials produced superior fluorescence to saline control, with approximately 8- and 14-fold increases with alginate and chitosan/β-GP injectables, and 47 and 59-fold increases achieved with collagen and alginate patches, respectively. Immunohistochemical...

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abstract

Cell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate if acute retention can be improved with a biomaterial carrier. Cells were quantified post-implantation in a rat myocardial infarct model in five groups (

 = 7–8); saline injection (current clinical standard), two injectable hydrogels (alginate, chitosan/β-glycerophosphate (chitosan/ß-GP)) and two epicardial patches (alginate, collagen). Human mesenchymal stem cells (hMSCs) were delivered to the infarct border zone with each biomaterial. At 24 h, retained cells were quantified by fluorescence. All biomaterials produced superior fluorescence to saline control, with approximately 8- and 14-fold increases with alginate and chitosan/β-GP injectables, and 47 and 59-fold increases achieved with collagen and alginate patches, respectively. Immunohistochemical...

pubElsevier Ltd
doi10.1016/j.biomaterials.2014.04.114
lad01Biomaterials
date2014-08