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Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology

Wound dressing biomaterials are increasingly being designed to incorporate bioactive molecules to promote healing, but the impact of matrix mechanical properties on the biology of resident cells orchestrating skin repair and regeneration remains to be fully understood. This study investigated whethe... Full description

Journal Title: Biomaterials October 2014, Vol.35(32), pp.8927-8936
Main Author: Branco Da Cunha, Cristiana
Other Authors: Klumpers, Darinka D , Li, Weiwei A , Koshy, Sandeep T , Weaver, James C , Chaudhuri, Ovijit , Granja, Pedro L , Mooney, David J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2014.06.047
Link: https://www.sciencedirect.com/science/article/pii/S0142961214007534
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2014_06_047
title: Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology
format: Article
creator:
  • Branco Da Cunha, Cristiana
  • Klumpers, Darinka D
  • Li, Weiwei A
  • Koshy, Sandeep T
  • Weaver, James C
  • Chaudhuri, Ovijit
  • Granja, Pedro L
  • Mooney, David J
subjects:
  • Wound Healing
  • Ecm (Extracellular Matrix)
  • Mechanical Properties
  • Interpenetrating Networks (Ipns)
  • Inflammation
  • Wound Dressing Biomaterial
  • Medicine
  • Engineering
ispartof: Biomaterials, October 2014, Vol.35(32), pp.8927-8936
description: Wound dressing biomaterials are increasingly being designed to incorporate bioactive molecules to promote healing, but the impact of matrix mechanical properties on the biology of resident cells orchestrating skin repair and regeneration remains to be fully understood. This study investigated whether tuning the stiffness of a model wound dressing biomaterial could control the behavior of dermal fibroblasts. Fully interpenetrating networks (IPNs) of collagen-I and alginate were fabricated to enable gel stiffness to be tuned independently of gel architecture, polymer concentration or adhesion ligand density. Three-dimensional cultures of dermal fibroblasts encapsulated within matrices of different stiffness were shown to promote dramatically different cell morphologies, and enhanced stiffness resulted in upregulation of key-mediators of inflammation such as IL-10 and COX-2. These findings suggest that simply modulating the matrix mechanical properties of a given wound dressing biomaterial...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2014.06.047
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleInfluence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology
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ispartofBiomaterials, October 2014, Vol.35(32), pp.8927-8936
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subjectWound Healing ; Ecm (Extracellular Matrix) ; Mechanical Properties ; Interpenetrating Networks (Ipns) ; Inflammation ; Wound Dressing Biomaterial ; Medicine ; Engineering
descriptionWound dressing biomaterials are increasingly being designed to incorporate bioactive molecules to promote healing, but the impact of matrix mechanical properties on the biology of resident cells orchestrating skin repair and regeneration remains to be fully understood. This study investigated whether tuning the stiffness of a model wound dressing biomaterial could control the behavior of dermal fibroblasts. Fully interpenetrating networks (IPNs) of collagen-I and alginate were fabricated to enable gel stiffness to be tuned independently of gel architecture, polymer concentration or adhesion ligand density. Three-dimensional cultures of dermal fibroblasts encapsulated within matrices of different stiffness were shown to promote dramatically different cell morphologies, and enhanced stiffness resulted in upregulation of key-mediators of inflammation such as IL-10 and COX-2. These findings suggest that simply modulating the matrix mechanical properties of a given wound dressing biomaterial...
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Wound dressing biomaterials are increasingly being designed to incorporate bioactive molecules to promote healing, but the impact of matrix mechanical properties on the biology of resident cells orchestrating skin repair and regeneration remains to be fully understood. This study investigated whether tuning the stiffness of a model wound dressing biomaterial could control the behavior of dermal fibroblasts. Fully interpenetrating networks (IPNs) of collagen-I and alginate were fabricated to enable gel stiffness to be tuned independently of gel architecture, polymer concentration or adhesion ligand density. Three-dimensional cultures of dermal fibroblasts encapsulated within matrices of different stiffness were shown to promote dramatically different cell morphologies, and enhanced stiffness resulted in upregulation of key-mediators of inflammation such as IL-10 and COX-2. These findings suggest that simply modulating the matrix mechanical properties of a given wound dressing biomaterial...

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Wound dressing biomaterials are increasingly being designed to incorporate bioactive molecules to promote healing, but the impact of matrix mechanical properties on the biology of resident cells orchestrating skin repair and regeneration remains to be fully understood. This study investigated whether tuning the stiffness of a model wound dressing biomaterial could control the behavior of dermal fibroblasts. Fully interpenetrating networks (IPNs) of collagen-I and alginate were fabricated to enable gel stiffness to be tuned independently of gel architecture, polymer concentration or adhesion ligand density. Three-dimensional cultures of dermal fibroblasts encapsulated within matrices of different stiffness were shown to promote dramatically different cell morphologies, and enhanced stiffness resulted in upregulation of key-mediators of inflammation such as IL-10 and COX-2. These findings suggest that simply modulating the matrix mechanical properties of a given wound dressing biomaterial...

pubElsevier Ltd
doi10.1016/j.biomaterials.2014.06.047
lad01Biomaterials
date2014-10