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Nanoparticle formulation of ormeloxifene for pancreatic cancer

Pancreatic cancer is the fourth most prevalent cancer with about an 85% mortality rate; thus, an utmost need exists to discover new therapeutic modalities that would enhance therapy outcomes of this disease with minimal or no side effects. Ormeloxifene (ORM), a synthetic molecule, has exhibited pote... Full description

Journal Title: Biomaterials June 2015, Vol.53, pp.731-743
Main Author: Khan, Sheema
Other Authors: Chauhan, Neeraj , Yallapu, Murali M , Ebeling, Mara C , Balakrishna, Swathi , Ellis, Robert T , Thompson, Paul A , Balabathula, Pavan , Behrman, Stephen W , Zafar, Nadeem , Singh, Man M , Halaweish, Fathi T , Jaggi, Meena , Chauhan, Subhash C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2015.02.082
Link: https://www.sciencedirect.com/science/article/pii/S0142961215002124
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2015_02_082
title: Nanoparticle formulation of ormeloxifene for pancreatic cancer
format: Article
creator:
  • Khan, Sheema
  • Chauhan, Neeraj
  • Yallapu, Murali M
  • Ebeling, Mara C
  • Balakrishna, Swathi
  • Ellis, Robert T
  • Thompson, Paul A
  • Balabathula, Pavan
  • Behrman, Stephen W
  • Zafar, Nadeem
  • Singh, Man M
  • Halaweish, Fathi T
  • Jaggi, Meena
  • Chauhan, Subhash C
subjects:
  • Pancreatic Cancer
  • Nanoparticles
  • Ormeloxifene
  • Drug Delivery
  • Cancer Therapeutics
  • Sonic Hedgehog
  • Medicine
  • Engineering
ispartof: Biomaterials, June 2015, Vol.53, pp.731-743
description: Pancreatic cancer is the fourth most prevalent cancer with about an 85% mortality rate; thus, an utmost need exists to discover new therapeutic modalities that would enhance therapy outcomes of this disease with minimal or no side effects. Ormeloxifene (ORM), a synthetic molecule, has exhibited potent anti-cancer effects through inhibition of important oncogenic and proliferation signaling pathways. However, the anti-cancer efficacy of ORM can be further improved by developing its nanoformulation, which will also offer tumor specific targeted delivery. Therefore, we have developed a novel ORM encapsulated poly(lactic- -glycolic acid) nanoparticle (NP) formulation (PLGA-ORM NP). This formulation was characterized for particle size, chemical composition, and drug loading efficiency, using various physico-chemical methods (TEM, FT-IR, DSC, TGA, and HPLC). Because of its facile composition, this novel formulation is compatible with antibody/aptamer conjugation to...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2015.02.082
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleNanoparticle formulation of ormeloxifene for pancreatic cancer
creatorKhan, Sheema ; Chauhan, Neeraj ; Yallapu, Murali M ; Ebeling, Mara C ; Balakrishna, Swathi ; Ellis, Robert T ; Thompson, Paul A ; Balabathula, Pavan ; Behrman, Stephen W ; Zafar, Nadeem ; Singh, Man M ; Halaweish, Fathi T ; Jaggi, Meena ; Chauhan, Subhash C
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subjectPancreatic Cancer ; Nanoparticles ; Ormeloxifene ; Drug Delivery ; Cancer Therapeutics ; Sonic Hedgehog ; Medicine ; Engineering
descriptionPancreatic cancer is the fourth most prevalent cancer with about an 85% mortality rate; thus, an utmost need exists to discover new therapeutic modalities that would enhance therapy outcomes of this disease with minimal or no side effects. Ormeloxifene (ORM), a synthetic molecule, has exhibited potent anti-cancer effects through inhibition of important oncogenic and proliferation signaling pathways. However, the anti-cancer efficacy of ORM can be further improved by developing its nanoformulation, which will also offer tumor specific targeted delivery. Therefore, we have developed a novel ORM encapsulated poly(lactic- -glycolic acid) nanoparticle (NP) formulation (PLGA-ORM NP). This formulation was characterized for particle size, chemical composition, and drug loading efficiency, using various physico-chemical methods (TEM, FT-IR, DSC, TGA, and HPLC). Because of its facile composition, this novel formulation is compatible with antibody/aptamer conjugation to...
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Pancreatic cancer is the fourth most prevalent cancer with about an 85% mortality rate; thus, an utmost need exists to discover new therapeutic modalities that would enhance therapy outcomes of this disease with minimal or no side effects. Ormeloxifene (ORM), a synthetic molecule, has exhibited potent anti-cancer effects through inhibition of important oncogenic and proliferation signaling pathways. However, the anti-cancer efficacy of ORM can be further improved by developing its nanoformulation, which will also offer tumor specific targeted delivery. Therefore, we have developed a novel ORM encapsulated poly(lactic-

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abstract

Pancreatic cancer is the fourth most prevalent cancer with about an 85% mortality rate; thus, an utmost need exists to discover new therapeutic modalities that would enhance therapy outcomes of this disease with minimal or no side effects. Ormeloxifene (ORM), a synthetic molecule, has exhibited potent anti-cancer effects through inhibition of important oncogenic and proliferation signaling pathways. However, the anti-cancer efficacy of ORM can be further improved by developing its nanoformulation, which will also offer tumor specific targeted delivery. Therefore, we have developed a novel ORM encapsulated poly(lactic-

-glycolic acid) nanoparticle (NP) formulation (PLGA-ORM NP). This formulation was characterized for particle size, chemical composition, and drug loading efficiency, using various physico-chemical methods (TEM, FT-IR, DSC, TGA, and HPLC). Because of its facile composition, this novel formulation is compatible with antibody/aptamer conjugation to...

pubElsevier Ltd
doi10.1016/j.biomaterials.2015.02.082
lad01Biomaterials
date2015-06