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Bioactive nanofibers enable the identification of thrombospondin 2 as a key player in enamel regeneration

Tissue regeneration and development involves highly synchronized signals both between cells and with the extracellular environment. Biomaterials can be tuned to mimic specific biological signals and control cell response(s). As a result, these materials can be used as tools to elucidate cell signali... Full description

Journal Title: Biomaterials August 2015, Vol.61, pp.216-228
Main Author: Huang, Zhan
Other Authors: Newcomb, Christina J , Lei, Yaping , Zhou, Yan , Bornstein, Paul , Amendt, Brad A , Stupp, Samuel I , Snead, Malcolm L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2015.05.035
Link: http://dx.doi.org/10.1016/j.biomaterials.2015.05.035
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2015_05_035
title: Bioactive nanofibers enable the identification of thrombospondin 2 as a key player in enamel regeneration
format: Article
creator:
  • Huang, Zhan
  • Newcomb, Christina J
  • Lei, Yaping
  • Zhou, Yan
  • Bornstein, Paul
  • Amendt, Brad A
  • Stupp, Samuel I
  • Snead, Malcolm L
subjects:
  • Peptide Amphiphile
  • Nano-Fabricated Artificial Matrix
  • Enamel Regeneration
  • Signaling Pathway
  • Thrombospondin 2
  • Peptide Amphiphile
  • Nano-Fabricated Artificial Matrix
  • Enamel Regeneration
  • Signaling Pathway
  • Thrombospondin 2
  • Medicine
  • Engineering
ispartof: Biomaterials, August 2015, Vol.61, pp.216-228
description: Tissue regeneration and development involves highly synchronized signals both between cells and with the extracellular environment. Biomaterials can be tuned to mimic specific biological signals and control cell response(s). As a result, these materials can be used as tools to elucidate cell signaling pathways and candidate molecules involved with cellular processes. In this work, we explore enamel-forming cells, ameloblasts, which have a limited regenerative capacity. By exposing undifferentiated cells to a self-assembling matrix bearing RGDS epitopes, we elicited a regenerative signal at will that subsequently led to the identification of thrombospondin 2 (TSP2), an extracellular matrix protein that has not been previously recognized as a key player in enamel development and regeneration. Targeted disruption of the thrombospondin 2 gene (Thbs2) resulted in enamel formation with a disordered architecture that was highly susceptible to wear compared to their wild-type counterparts....
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2015.05.035
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleBioactive nanofibers enable the identification of thrombospondin 2 as a key player in enamel regeneration
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ispartofBiomaterials, August 2015, Vol.61, pp.216-228
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subjectPeptide Amphiphile ; Nano-Fabricated Artificial Matrix ; Enamel Regeneration ; Signaling Pathway ; Thrombospondin 2 ; Peptide Amphiphile ; Nano-Fabricated Artificial Matrix ; Enamel Regeneration ; Signaling Pathway ; Thrombospondin 2 ; Medicine ; Engineering
descriptionTissue regeneration and development involves highly synchronized signals both between cells and with the extracellular environment. Biomaterials can be tuned to mimic specific biological signals and control cell response(s). As a result, these materials can be used as tools to elucidate cell signaling pathways and candidate molecules involved with cellular processes. In this work, we explore enamel-forming cells, ameloblasts, which have a limited regenerative capacity. By exposing undifferentiated cells to a self-assembling matrix bearing RGDS epitopes, we elicited a regenerative signal at will that subsequently led to the identification of thrombospondin 2 (TSP2), an extracellular matrix protein that has not been previously recognized as a key player in enamel development and regeneration. Targeted disruption of the thrombospondin 2 gene (Thbs2) resulted in enamel formation with a disordered architecture that was highly susceptible to wear compared to their wild-type counterparts....
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Tissue regeneration and development involves highly synchronized signals both between cells and with the extracellular environment. Biomaterials can be tuned to mimic specific biological signals and control cell response(s). As a result, these materials can be used as tools to elucidate cell signaling pathways and candidate molecules involved with cellular processes. In this work, we explore enamel-forming cells, ameloblasts, which have a limited regenerative capacity. By exposing undifferentiated cells to a self-assembling matrix bearing RGDS epitopes, we elicited a regenerative signal at will that subsequently led to the identification of thrombospondin 2 (TSP2), an extracellular matrix protein that has not been previously recognized as a key player in enamel development and regeneration. Targeted disruption of the thrombospondin 2 gene (Thbs2) resulted in enamel formation with a disordered architecture that was highly susceptible to wear compared to their wild-type counterparts....

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Tissue regeneration and development involves highly synchronized signals both between cells and with the extracellular environment. Biomaterials can be tuned to mimic specific biological signals and control cell response(s). As a result, these materials can be used as tools to elucidate cell signaling pathways and candidate molecules involved with cellular processes. In this work, we explore enamel-forming cells, ameloblasts, which have a limited regenerative capacity. By exposing undifferentiated cells to a self-assembling matrix bearing RGDS epitopes, we elicited a regenerative signal at will that subsequently led to the identification of thrombospondin 2 (TSP2), an extracellular matrix protein that has not been previously recognized as a key player in enamel development and regeneration. Targeted disruption of the thrombospondin 2 gene (Thbs2) resulted in enamel formation with a disordered architecture that was highly susceptible to wear compared to their wild-type counterparts....

pubElsevier Ltd
doi10.1016/j.biomaterials.2015.05.035
lad01Biomaterials
date2015-08