schliessen

Filtern

 

Bibliotheken

Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model

Parkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by de... Full description

Journal Title: Biomaterials September 2015, Vol.64, pp.45-56
Main Author: Kim, Mi Jin
Other Authors: Park, Meeyoung , Kim, Dae Won , Shin, Min Jea , Son, Ora , Jo, Hyo Sang , Yeo, Hyeon Ji , Cho, Su Bin , Park, Jung Hwan , Lee, Chi Hern , Kim, Duk-Soo , Kwon, Oh-Shin , Kim, Joon , Han, Kyu Hyung , Park, Jinseu , Eum, Won Sik , Choi, Soo Young
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2015.06.015
Link: http://dx.doi.org/10.1016/j.biomaterials.2015.06.015
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_biomaterials_2015_06_015
title: Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model
format: Article
creator:
  • Kim, Mi Jin
  • Park, Meeyoung
  • Kim, Dae Won
  • Shin, Min Jea
  • Son, Ora
  • Jo, Hyo Sang
  • Yeo, Hyeon Ji
  • Cho, Su Bin
  • Park, Jung Hwan
  • Lee, Chi Hern
  • Kim, Duk-Soo
  • Kwon, Oh-Shin
  • Kim, Joon
  • Han, Kyu Hyung
  • Park, Jinseu
  • Eum, Won Sik
  • Choi, Soo Young
subjects:
  • Parkinson'S Disease
  • PEP-1-Pon1
  • Inflammation
  • Dopaminergic Neuronal Death
  • Oxidative Stress
  • Protein Therapy
  • Parkinson'S Disease
  • PEP-1-Pon1
  • Inflammation
  • Dopaminergic Neuronal Death
  • Oxidative Stress
  • Protein Therapy
  • Medicine
  • Engineering
ispartof: Biomaterials, September 2015, Vol.64, pp.45-56
description: Parkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by destroying biologically active phospholipids with potential protective effects against oxidative stress-induced inflammatory disorders. In a previous study, we constructed protein transduction domain (PTD) fusion PEP-1-PON1 protein to transduce PON1 into cells and tissue. In this study, we examined the role of transduced PEP-1-PON1 protein in repressing oxidative stress-mediated inflammatory response in microglial BV2 cells after exposure to lipopolysaccharide (LPS). Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2015.06.015
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


@attributes
ID1666424384
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_biomaterials_2015_06_015
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_biomaterials_2015_06_015
sourcesystemPC
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADALY
29ADEWK
30ADTZH
31ADUVX
32AECPX
33AEHWI
34AEKER
35AEVXI
36AEZYN
37AFKWA
38AFTJW
39AFXIZ
40AGHFR
41AGRDE
42AGUBO
43AGYEJ
44AHHHB
45AHPOS
46AIKHN
47AITUG
48AJBFU
49AJOXV
50AJUYK
51AMFUW
52BJAXD
53BLXMC
54DOVZS
55ENUVR
56EO8
57EO9
58EP2
59EP3
60FDB
61FGOYB
62FIRID
63FNPLU
64G-Q
65GBLVA
66HMK
67HMO
68J1W
69JJJVA
70KOM
71MAGPM
72OAUVE
73OB-
74OM.
75P-8
76P-9
77PC.
78Q38
79R2-
80RPZ
81SAE
82SCC
83SDF
84SDG
85SDP
86SES
87SEW
88SMS
89SPC
90SSG
91SSM
92SST
93SSU
94SSZ
95T5K
96Z5R
97~G-
pqid1746894339
galeid519870627
display
typearticle
titleTransduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model
creatorKim, Mi Jin ; Park, Meeyoung ; Kim, Dae Won ; Shin, Min Jea ; Son, Ora ; Jo, Hyo Sang ; Yeo, Hyeon Ji ; Cho, Su Bin ; Park, Jung Hwan ; Lee, Chi Hern ; Kim, Duk-Soo ; Kwon, Oh-Shin ; Kim, Joon ; Han, Kyu Hyung ; Park, Jinseu ; Eum, Won Sik ; Choi, Soo Young
ispartofBiomaterials, September 2015, Vol.64, pp.45-56
identifier
subjectParkinson'S Disease ; PEP-1-Pon1 ; Inflammation ; Dopaminergic Neuronal Death ; Oxidative Stress ; Protein Therapy ; Parkinson'S Disease ; PEP-1-Pon1 ; Inflammation ; Dopaminergic Neuronal Death ; Oxidative Stress ; Protein Therapy ; Medicine ; Engineering
descriptionParkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by destroying biologically active phospholipids with potential protective effects against oxidative stress-induced inflammatory disorders. In a previous study, we constructed protein transduction domain (PTD) fusion PEP-1-PON1 protein to transduce PON1 into cells and tissue. In this study, we examined the role of transduced PEP-1-PON1 protein in repressing oxidative stress-mediated inflammatory response in microglial BV2 cells after exposure to lipopolysaccharide (LPS). Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression...
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1016/j.biomaterials.2015.06.015$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Kim, Mi Jin
1Park, Meeyoung
2Kim, Dae Won
3Shin, Min Jea
4Son, Ora
5Jo, Hyo Sang
6Yeo, Hyeon Ji
7Cho, Su Bin
8Park, Jung Hwan
9Lee, Chi Hern
10Kim, Duk-Soo
11Kwon, Oh-Shin
12Kim, Joon
13Han, Kyu Hyung
14Park, Jinseu
15Eum, Won Sik
16Choi, Soo Young
titleTransduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model
description

Parkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by destroying biologically active phospholipids with potential protective effects against oxidative stress-induced inflammatory disorders. In a previous study, we constructed protein transduction domain (PTD) fusion PEP-1-PON1 protein to transduce PON1 into cells and tissue. In this study, we examined the role of transduced PEP-1-PON1 protein in repressing oxidative stress-mediated inflammatory response in microglial BV2 cells after exposure to lipopolysaccharide (LPS). Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression...

subject
0Parkinson'S Disease
1PEP-1-Pon1
2Inflammation
3Dopaminergic Neuronal Death
4Oxidative Stress
5Protein Therapy
6Medicine
7Engineering
general
0English
1Elsevier Ltd
210.1016/j.biomaterials.2015.06.015
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_biomaterials_2015_06_015
issn
00142-9612
101429612
21878-5905
318785905
rsrctypearticle
creationdate2015
addtitleBiomaterials
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADALY
29ADEWK
30ADTZH
31ADUVX
32AECPX
33AEHWI
34AEKER
35AEVXI
36AEZYN
37AFKWA
38AFTJW
39AFXIZ
40AGHFR
41AGRDE
42AGUBO
43AGYEJ
44AHHHB
45AHPOS
46AIKHN
47AITUG
48AJBFU
49AJOXV
50AJUYK
51AMFUW
52BJAXD
53BLXMC
54DOVZS
55ENUVR
56EO8
57EO9
58EP2
59EP3
60FDB
61FGOYB
62FIRID
63FNPLU
64G-Q
65GBLVA
66HMK
67HMO
68J1W
69JJJVA
70KOM
71MAGPM
72OAUVE
73OB-
74OM.
75P-8
76P-9
77PC.
78Q38
79R2-
80RPZ
81SAE
82SCC
83SDF
84SDG
85SDP
86SES
87SEW
88SMS
89SPC
90SSG
91SSM
92SST
93SSU
94SSZ
95T5K
96Z5R
97~G-
startdate20150901
enddate20150931
lsr40Biomaterials, September 2015, Vol.64, pp.45-56
doi10.1016/j.biomaterials.2015.06.015
citationpf 45 pt 56 vol 64
lsr30VSR-Enriched:[galeid, pqid]
sort
titleTransduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model
authorKim, Mi Jin ; Park, Meeyoung ; Kim, Dae Won ; Shin, Min Jea ; Son, Ora ; Jo, Hyo Sang ; Yeo, Hyeon Ji ; Cho, Su Bin ; Park, Jung Hwan ; Lee, Chi Hern ; Kim, Duk-Soo ; Kwon, Oh-Shin ; Kim, Joon ; Han, Kyu Hyung ; Park, Jinseu ; Eum, Won Sik ; Choi, Soo Young
creationdate20150900
lso0120150900
facets
frbrgroupid3837524613845881394
frbrtype5
newrecords20190904
languageeng
topic
0Parkinson'S Disease
1PEP-1-Pon1
2Inflammation
3Dopaminergic Neuronal Death
4Oxidative Stress
5Protein Therapy
6Medicine
7Engineering
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Kim, Mi Jin
1Park, Meeyoung
2Kim, Dae Won
3Shin, Min Jea
4Son, Ora
5Jo, Hyo Sang
6Yeo, Hyeon Ji
7Cho, Su Bin
8Park, Jung Hwan
9Lee, Chi Hern
10Kim, Duk-Soo
11Kwon, Oh-Shin
12Kim, Joon
13Han, Kyu Hyung
14Park, Jinseu
15Eum, Won Sik
16Choi, Soo Young
jtitleBiomaterials
creationdate2015
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Kim
1Park
2Shin
3Son
4Jo
5Yeo
6Cho
7Lee
8Kwon
9Han
10Eum
11Choi
aufirst
0Mi Jin
1Meeyoung
2Dae Won
3Min Jea
4Ora
5Hyo Sang
6Hyeon Ji
7Su Bin
8Jung Hwan
9Chi Hern
10Duk-Soo
11Oh-Shin
12Joon
13Kyu Hyung
14Jinseu
15Won Sik
16Soo Young
auinitM
auinit1M
au
0Kim, Mi Jin
1Park, Meeyoung
2Kim, Dae Won
3Shin, Min Jea
4Son, Ora
5Jo, Hyo Sang
6Yeo, Hyeon Ji
7Cho, Su Bin
8Park, Jung Hwan
9Lee, Chi Hern
10Kim, Duk-Soo
11Kwon, Oh-Shin
12Kim, Joon
13Han, Kyu Hyung
14Park, Jinseu
15Eum, Won Sik
16Choi, Soo Young
atitleTransduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model
jtitleBiomaterials
risdate201509
volume64
spage45
epage56
pages45-56
issn0142-9612
eissn1878-5905
formatjournal
genrearticle
ristypeJOUR
abstract

Parkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by destroying biologically active phospholipids with potential protective effects against oxidative stress-induced inflammatory disorders. In a previous study, we constructed protein transduction domain (PTD) fusion PEP-1-PON1 protein to transduce PON1 into cells and tissue. In this study, we examined the role of transduced PEP-1-PON1 protein in repressing oxidative stress-mediated inflammatory response in microglial BV2 cells after exposure to lipopolysaccharide (LPS). Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression...

pubElsevier Ltd
doi10.1016/j.biomaterials.2015.06.015
lad01Biomaterials
date2015-09