schliessen

Filtern

 

Bibliotheken

A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing transport of chemotherapeutics into the tumor. The g... Full description

Journal Title: Biomaterials July 2016, Vol.93, pp.71-82
Main Author: Indolfi, Laura
Other Authors: Ligorio, Matteo , Ting, David T , Xega, Kristina , Tzafriri, Abraham R , Bersani, Francesca , Aceto, Nicola , Thapar, Vishal , Fuchs, Bryan C , Deshpande, Vikram , Baker, Aaron B , Ferrone, Cristina R , Haber, Daniel A , Langer, Robert , Clark, Jeffrey W , Edelman, Elazer R
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2016.03.044
Link: https://www.sciencedirect.com/science/article/pii/S0142961216300837
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_biomaterials_2016_03_044
title: A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma
format: Article
creator:
  • Indolfi, Laura
  • Ligorio, Matteo
  • Ting, David T
  • Xega, Kristina
  • Tzafriri, Abraham R
  • Bersani, Francesca
  • Aceto, Nicola
  • Thapar, Vishal
  • Fuchs, Bryan C
  • Deshpande, Vikram
  • Baker, Aaron B
  • Ferrone, Cristina R
  • Haber, Daniel A
  • Langer, Robert
  • Clark, Jeffrey W
  • Edelman, Elazer R
subjects:
  • Pancreatic Cancer
  • Chemoresistance
  • Local Delivery
  • Patient-Derived Xenograft
  • Paclitaxel
  • Poly(Lactic-Co-Glycolic Acid)
  • Medicine
  • Engineering
ispartof: Biomaterials, July 2016, Vol.93, pp.71-82
description: Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing transport of chemotherapeutics into the tumor. The growth of the tumor in pancreatic cancer often leads to invasion of other organs and partial or complete biliary obstruction, inducing intense pain for patients and necessitating tumor resection or repeated stenting. Here, we have developed a delivery device to provide enhanced palliative therapy for pancreatic cancer patients by providing high concentrations of chemotherapeutic compounds locally at the tumor site. This treatment could reduce the need for repeated procedures in advanced PDAC patients to debulk the tumor mass or stent the obstructed bile duct. To facilitate clinical translation, we created the device out of currently approved materials and drugs. We engineered an implantable...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2016.03.044
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


@attributes
ID1932668047
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_biomaterials_2016_03_044
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_biomaterials_2016_03_044
sourcesystemPC
dbid
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
pqid1784463109
galeid522039255
display
typearticle
titleA tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma
creatorIndolfi, Laura ; Ligorio, Matteo ; Ting, David T ; Xega, Kristina ; Tzafriri, Abraham R ; Bersani, Francesca ; Aceto, Nicola ; Thapar, Vishal ; Fuchs, Bryan C ; Deshpande, Vikram ; Baker, Aaron B ; Ferrone, Cristina R ; Haber, Daniel A ; Langer, Robert ; Clark, Jeffrey W ; Edelman, Elazer R
ispartofBiomaterials, July 2016, Vol.93, pp.71-82
identifier
subjectPancreatic Cancer ; Chemoresistance ; Local Delivery ; Patient-Derived Xenograft ; Paclitaxel ; Poly(Lactic-Co-Glycolic Acid) ; Medicine ; Engineering
descriptionPancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing transport of chemotherapeutics into the tumor. The growth of the tumor in pancreatic cancer often leads to invasion of other organs and partial or complete biliary obstruction, inducing intense pain for patients and necessitating tumor resection or repeated stenting. Here, we have developed a delivery device to provide enhanced palliative therapy for pancreatic cancer patients by providing high concentrations of chemotherapeutic compounds locally at the tumor site. This treatment could reduce the need for repeated procedures in advanced PDAC patients to debulk the tumor mass or stent the obstructed bile duct. To facilitate clinical translation, we created the device out of currently approved materials and drugs. We engineered an implantable...
languageeng
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961216300837$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Indolfi, Laura
1Ligorio, Matteo
2Ting, David T
3Xega, Kristina
4Tzafriri, Abraham R
5Bersani, Francesca
6Aceto, Nicola
7Thapar, Vishal
8Fuchs, Bryan C
9Deshpande, Vikram
10Baker, Aaron B
11Ferrone, Cristina R
12Haber, Daniel A
13Langer, Robert
14Clark, Jeffrey W
15Edelman, Elazer R
titleA tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma
description

Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing transport of chemotherapeutics into the tumor. The growth of the tumor in pancreatic cancer often leads to invasion of other organs and partial or complete biliary obstruction, inducing intense pain for patients and necessitating tumor resection or repeated stenting. Here, we have developed a delivery device to provide enhanced palliative therapy for pancreatic cancer patients by providing high concentrations of chemotherapeutic compounds locally at the tumor site. This treatment could reduce the need for repeated procedures in advanced PDAC patients to debulk the tumor mass or stent the obstructed bile duct. To facilitate clinical translation, we created the device out of currently approved materials and drugs. We engineered an implantable...

subject
0Pancreatic Cancer
1Chemoresistance
2Local Delivery
3Patient-Derived Xenograft
4Paclitaxel
5Poly(Lactic-Co-Glycolic Acid)
6Medicine
7Engineering
general
0English
1Elsevier Ltd
210.1016/j.biomaterials.2016.03.044
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_biomaterials_2016_03_044
issn
00142-9612
101429612
21878-5905
318785905
rsrctypearticle
creationdate2016
addtitleBiomaterials
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.FO
3.~1
41B1
51P~
61RT
71~.
8457
94G.
107-5
118P~
129JM
139JN
14AABNK
15AAEDT
16AAEPC
17AAKOC
18AAOAW
19AAQFI
20ABFNM
21ABGSF
22ABNUV
23ABXRA
24ABYKQ
25ACDAQ
26ACIUM
27ACRLP
28ADEWK
29ADTZH
30ADUVX
31AECPX
32AEHWI
33AEKER
34AEVXI
35AEZYN
36AFKWA
37AFTJW
38AFXIZ
39AGHFR
40AGRDE
41AGUBO
42AGYEJ
43AHHHB
44AHPOS
45AIKHN
46AITUG
47AJBFU
48AJOXV
49AJUYK
50AMFUW
51BJAXD
52BLXMC
53DOVZS
54ENUVR
55EO8
56EO9
57EP2
58EP3
59FDB
60FGOYB
61FIRID
62FNPLU
63G-Q
64GBLVA
65HMK
66HMO
67J1W
68JJJVA
69KOM
70MAGPM
71OAUVE
72OB-
73OM.
74P-8
75P-9
76PC.
77Q38
78R2-
79RPZ
80SAE
81SCC
82SDF
83SDG
84SDP
85SES
86SEW
87SMS
88SPC
89SSG
90SSM
91SST
92SSU
93SSZ
94T5K
95Z5R
96~G-
startdate20160701
enddate20160731
lsr40Biomaterials, July 2016, Vol.93, pp.71-82
doi10.1016/j.biomaterials.2016.03.044
citationpf 71 pt 82 vol 93
lsr30VSR-Enriched:[pqid, galeid]
sort
titleA tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma
authorIndolfi, Laura ; Ligorio, Matteo ; Ting, David T ; Xega, Kristina ; Tzafriri, Abraham R ; Bersani, Francesca ; Aceto, Nicola ; Thapar, Vishal ; Fuchs, Bryan C ; Deshpande, Vikram ; Baker, Aaron B ; Ferrone, Cristina R ; Haber, Daniel A ; Langer, Robert ; Clark, Jeffrey W ; Edelman, Elazer R
creationdate20160700
lso0120160700
facets
frbrgroupid-3233658694605863599
frbrtype5
newrecords20190904
languageeng
topic
0Pancreatic Cancer
1Chemoresistance
2Local Delivery
3Patient-Derived Xenograft
4Paclitaxel
5Poly(Lactic-Co-Glycolic Acid)
6Medicine
7Engineering
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Indolfi, Laura
1Ligorio, Matteo
2Ting, David T
3Xega, Kristina
4Tzafriri, Abraham R
5Bersani, Francesca
6Aceto, Nicola
7Thapar, Vishal
8Fuchs, Bryan C
9Deshpande, Vikram
10Baker, Aaron B
11Ferrone, Cristina R
12Haber, Daniel A
13Langer, Robert
14Clark, Jeffrey W
15Edelman, Elazer R
jtitleBiomaterials
creationdate2016
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Indolfi
1Ligorio
2Ting
3Xega
4Tzafriri
5Bersani
6Aceto
7Thapar
8Fuchs
9Deshpande
10Baker
11Ferrone
12Haber
13Langer
14Clark
15Edelman
aufirst
0Laura
1Matteo
2David T
3Kristina
4Abraham R
5Francesca
6Nicola
7Vishal
8Bryan C
9Vikram
10Aaron B
11Cristina R
12Daniel A
13Robert
14Jeffrey W
15Elazer R
auinitL
auinit1L
au
0Indolfi, Laura
1Ligorio, Matteo
2Ting, David T
3Xega, Kristina
4Tzafriri, Abraham R
5Bersani, Francesca
6Aceto, Nicola
7Thapar, Vishal
8Fuchs, Bryan C
9Deshpande, Vikram
10Baker, Aaron B
11Ferrone, Cristina R
12Haber, Daniel A
13Langer, Robert
14Clark, Jeffrey W
15Edelman, Elazer R
atitleA tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma
jtitleBiomaterials
risdate201607
volume93
spage71
epage82
pages71-82
issn0142-9612
eissn1878-5905
formatjournal
genrearticle
ristypeJOUR
abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing transport of chemotherapeutics into the tumor. The growth of the tumor in pancreatic cancer often leads to invasion of other organs and partial or complete biliary obstruction, inducing intense pain for patients and necessitating tumor resection or repeated stenting. Here, we have developed a delivery device to provide enhanced palliative therapy for pancreatic cancer patients by providing high concentrations of chemotherapeutic compounds locally at the tumor site. This treatment could reduce the need for repeated procedures in advanced PDAC patients to debulk the tumor mass or stent the obstructed bile duct. To facilitate clinical translation, we created the device out of currently approved materials and drugs. We engineered an implantable...

pubElsevier Ltd
doi10.1016/j.biomaterials.2016.03.044
lad01Biomaterials
date2016-07