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Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy

Immunogenic cell death (ICD) occurs when apoptotic tumor cell elicits a specific immune response, which may trigger an anti-tumor effect, via the release of immunostimulatory damage-associated molecular patterns (DAMPs). Hypothesizing that nanomedicines may impact ICD due to their proven advantages... Full description

Journal Title: Biomaterials September 2016, Vol.102, pp.187-197
Main Author: Zhao, Xiao
Other Authors: Yang, Keni , Zhao, Ruifang , Ji, Tianjiao , Wang, Xiuchao , Yang, Xiao , Zhang, Yinlong , Cheng, Keman , Liu, Shaoli , Hao, Jihui , Ren, He , Leong, Kam W , Nie, Guangjun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2016.06.032
Link: https://www.sciencedirect.com/science/article/pii/S0142961216302861
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2016_06_032
title: Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy
format: Article
creator:
  • Zhao, Xiao
  • Yang, Keni
  • Zhao, Ruifang
  • Ji, Tianjiao
  • Wang, Xiuchao
  • Yang, Xiao
  • Zhang, Yinlong
  • Cheng, Keman
  • Liu, Shaoli
  • Hao, Jihui
  • Ren, He
  • Leong, Kam W
  • Nie, Guangjun
subjects:
  • Nanocarriers
  • Immunogenic Cell Death
  • Dendritic Cells
  • Oxaliplatin
  • Gemcitabine
  • Pancreatic Cancer
  • Medicine
  • Engineering
ispartof: Biomaterials, September 2016, Vol.102, pp.187-197
description: Immunogenic cell death (ICD) occurs when apoptotic tumor cell elicits a specific immune response, which may trigger an anti-tumor effect, via the release of immunostimulatory damage-associated molecular patterns (DAMPs). Hypothesizing that nanomedicines may impact ICD due to their proven advantages in delivery of chemotherapeutics, we encapsulated oxaliplatin (OXA) or gemcitabine (GEM), an ICD and a non-ICD inducer respectively, into the amphiphilic diblock copolymer nanoparticles. Neither GEM nor nanoparticle-encapsulated GEM (NP-GEM) induced ICD, while both OXA and nanoparticle-encapsulated OXA (NP-OXA) induced ICD. Interestingly, NP-OXA treated tumor cells released more DAMPs and induced stronger immune responses of dendritic cells and T lymphocytes than OXA treatment . Furthermore, OXA and NP-OXA exhibited stronger therapeutic effects in immunocompetent mice than in immunodeficient mice, and the enhancement of therapeutic efficacy was significantly higher...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2016.06.032
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleInducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy
creatorZhao, Xiao ; Yang, Keni ; Zhao, Ruifang ; Ji, Tianjiao ; Wang, Xiuchao ; Yang, Xiao ; Zhang, Yinlong ; Cheng, Keman ; Liu, Shaoli ; Hao, Jihui ; Ren, He ; Leong, Kam W ; Nie, Guangjun
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subjectNanocarriers ; Immunogenic Cell Death ; Dendritic Cells ; Oxaliplatin ; Gemcitabine ; Pancreatic Cancer ; Medicine ; Engineering
descriptionImmunogenic cell death (ICD) occurs when apoptotic tumor cell elicits a specific immune response, which may trigger an anti-tumor effect, via the release of immunostimulatory damage-associated molecular patterns (DAMPs). Hypothesizing that nanomedicines may impact ICD due to their proven advantages in delivery of chemotherapeutics, we encapsulated oxaliplatin (OXA) or gemcitabine (GEM), an ICD and a non-ICD inducer respectively, into the amphiphilic diblock copolymer nanoparticles. Neither GEM nor nanoparticle-encapsulated GEM (NP-GEM) induced ICD, while both OXA and nanoparticle-encapsulated OXA (NP-OXA) induced ICD. Interestingly, NP-OXA treated tumor cells released more DAMPs and induced stronger immune responses of dendritic cells and T lymphocytes than OXA treatment . Furthermore, OXA and NP-OXA exhibited stronger therapeutic effects in immunocompetent mice than in immunodeficient mice, and the enhancement of therapeutic efficacy was significantly higher...
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titleInducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy
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Immunogenic cell death (ICD) occurs when apoptotic tumor cell elicits a specific immune response, which may trigger an anti-tumor effect, via the release of immunostimulatory damage-associated molecular patterns (DAMPs). Hypothesizing that nanomedicines may impact ICD due to their proven advantages in delivery of chemotherapeutics, we encapsulated oxaliplatin (OXA) or gemcitabine (GEM), an ICD and a non-ICD inducer respectively, into the amphiphilic diblock copolymer nanoparticles. Neither GEM nor nanoparticle-encapsulated GEM (NP-GEM) induced ICD, while both OXA and nanoparticle-encapsulated OXA (NP-OXA) induced ICD. Interestingly, NP-OXA treated tumor cells released more DAMPs and induced stronger immune responses of dendritic cells and T lymphocytes than OXA treatment

. Furthermore, OXA and NP-OXA exhibited stronger therapeutic effects in immunocompetent mice than in immunodeficient mice, and the enhancement of therapeutic efficacy was significantly higher...

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Immunogenic cell death (ICD) occurs when apoptotic tumor cell elicits a specific immune response, which may trigger an anti-tumor effect, via the release of immunostimulatory damage-associated molecular patterns (DAMPs). Hypothesizing that nanomedicines may impact ICD due to their proven advantages in delivery of chemotherapeutics, we encapsulated oxaliplatin (OXA) or gemcitabine (GEM), an ICD and a non-ICD inducer respectively, into the amphiphilic diblock copolymer nanoparticles. Neither GEM nor nanoparticle-encapsulated GEM (NP-GEM) induced ICD, while both OXA and nanoparticle-encapsulated OXA (NP-OXA) induced ICD. Interestingly, NP-OXA treated tumor cells released more DAMPs and induced stronger immune responses of dendritic cells and T lymphocytes than OXA treatment

. Furthermore, OXA and NP-OXA exhibited stronger therapeutic effects in immunocompetent mice than in immunodeficient mice, and the enhancement of therapeutic efficacy was significantly higher...

pubElsevier Ltd
doi10.1016/j.biomaterials.2016.06.032
lad01Biomaterials
date2016-09