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Dental cell sheet biomimetic tooth bud model

Tissue engineering and regenerative medicine technologies offer promising therapies for both medicine and dentistry. Our long-term goal is to create functional biomimetic tooth buds for eventual tooth replacement in humans. Here, our objective was to create a biomimetic 3D tooth bud model consisting... Full description

Journal Title: Biomaterials November 2016, Vol.106, pp.167-179
Main Author: Monteiro, Nelson
Other Authors: Smith, Elizabeth E , Angstadt, Shantel , Zhang, Weibo , Khademhosseini, Ali , Yelick, Pamela C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2016.08.024
Link: https://www.sciencedirect.com/science/article/pii/S0142961216304100
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recordid: elsevier_sdoi_10_1016_j_biomaterials_2016_08_024
title: Dental cell sheet biomimetic tooth bud model
format: Article
creator:
  • Monteiro, Nelson
  • Smith, Elizabeth E
  • Angstadt, Shantel
  • Zhang, Weibo
  • Khademhosseini, Ali
  • Yelick, Pamela C
subjects:
  • Tooth Development
  • Dental Stem Cells
  • Tissue Engineering
  • Regenerative Medicine
  • Biomaterials
  • Medicine
  • Engineering
ispartof: Biomaterials, November 2016, Vol.106, pp.167-179
description: Tissue engineering and regenerative medicine technologies offer promising therapies for both medicine and dentistry. Our long-term goal is to create functional biomimetic tooth buds for eventual tooth replacement in humans. Here, our objective was to create a biomimetic 3D tooth bud model consisting of dental epithelial (DE) – dental mesenchymal (DM) cell sheets (CSs) combined with biomimetic enamel organ and pulp organ layers created using GelMA hydrogels. Pig DE or DM cells seeded on temperature-responsive plates at various cell densities (0.02, 0.114 and 0.228 cells 10 /cm ) and cultured for 7, 14 and 21 days were used to generate DE and DM cell sheets, respectively. Dental CSs were combined with GelMA encapsulated DE and DM cell layers to form bioengineered 3D tooth buds. Biomimetic 3D tooth bud constructs were cultured , or implanted for 3 weeks. Analyses were performed using micro-CT, H&E...
language: eng
source:
identifier: ISSN: 0142-9612 ; E-ISSN: 1878-5905 ; DOI: 10.1016/j.biomaterials.2016.08.024
fulltext: fulltext
issn:
  • 0142-9612
  • 01429612
  • 1878-5905
  • 18785905
url: Link


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titleDental cell sheet biomimetic tooth bud model
creatorMonteiro, Nelson ; Smith, Elizabeth E ; Angstadt, Shantel ; Zhang, Weibo ; Khademhosseini, Ali ; Yelick, Pamela C
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subjectTooth Development ; Dental Stem Cells ; Tissue Engineering ; Regenerative Medicine ; Biomaterials ; Medicine ; Engineering
descriptionTissue engineering and regenerative medicine technologies offer promising therapies for both medicine and dentistry. Our long-term goal is to create functional biomimetic tooth buds for eventual tooth replacement in humans. Here, our objective was to create a biomimetic 3D tooth bud model consisting of dental epithelial (DE) – dental mesenchymal (DM) cell sheets (CSs) combined with biomimetic enamel organ and pulp organ layers created using GelMA hydrogels. Pig DE or DM cells seeded on temperature-responsive plates at various cell densities (0.02, 0.114 and 0.228 cells 10 /cm ) and cultured for 7, 14 and 21 days were used to generate DE and DM cell sheets, respectively. Dental CSs were combined with GelMA encapsulated DE and DM cell layers to form bioengineered 3D tooth buds. Biomimetic 3D tooth bud constructs were cultured , or implanted for 3 weeks. Analyses were performed using micro-CT, H&E...
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