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Significance of oxygen supply in production of a novel antibiotic by Pseudomonas sp. SJT25

Highlights► Production of a novel powerful antibiotic, HHCA, was significantly improved. ► Oxygen supply was found to be a key factor in fermentation of a newly isolated Pseudomonas sp. SJT25. ► An oxygen supply strategy was proposed and successfully applied in a bubble column bioreactor. ► The work... Full description

Journal Title: Bioresource Technology October 2011, Vol.102(19), pp.9167-9174
Main Author: Xu, Yan
Other Authors: Zhong, Jian-Jiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0960-8524 ; E-ISSN: 1873-2976 ; DOI: 10.1016/j.biortech.2011.07.011
Link: https://www.sciencedirect.com/science/article/pii/S0960852411009370
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recordid: elsevier_sdoi_10_1016_j_biortech_2011_07_011
title: Significance of oxygen supply in production of a novel antibiotic by Pseudomonas sp. SJT25
format: Article
creator:
  • Xu, Yan
  • Zhong, Jian-Jiang
subjects:
  • Antibiotic Production
  • Oxygen Supply
  • Initial Kla
  • Bubble Column Bioreactor
  • Pseudomonas Strains
  • Agriculture
  • Engineering
  • Chemistry
ispartof: Bioresource Technology, October 2011, Vol.102(19), pp.9167-9174
description: Highlights► Production of a novel powerful antibiotic, HHCA, was significantly improved. ► Oxygen supply was found to be a key factor in fermentation of a newly isolated Pseudomonas sp. SJT25. ► An oxygen supply strategy was proposed and successfully applied in a bubble column bioreactor. ► The work is helpful to large scale production of the promising new antibiotic and to its future application in agriculture. A new agricultural antibiotic, 2-heptyl-5-hexylfuran-3-carboxylic acid (HHCA), was recently discovered, but its further application was limited due to its low production titer. In shake flask fermentation, the effect of initial KLa within the range of 2.12–18.87h−1 on HHCA production was investigated. The cell growth and glycerol consumption were faster at a higher initial KLa value, but the maximum production (14.43mg/L) was attained at an initial KLa value of 12.46h−1. The oxygen supply information was further applied to a 2-L bubble column bioreactor (BCB) by varying initial KLa from 1.45 to 30.18h−1, and the hyperproduction of HHCA was achieved at a relatively low initial KLa around 5–10h−1. The control of oxygen supply is considered to be an important strategy to enhance HHCA production, and the information obtained will be useful to production of this powerful new antibiotic on a large scale.
language: eng
source:
identifier: ISSN: 0960-8524 ; E-ISSN: 1873-2976 ; DOI: 10.1016/j.biortech.2011.07.011
fulltext: no_fulltext
issn:
  • 0960-8524
  • 09608524
  • 1873-2976
  • 18732976
url: Link


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titleSignificance of oxygen supply in production of a novel antibiotic by Pseudomonas sp. SJT25
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descriptionHighlights► Production of a novel powerful antibiotic, HHCA, was significantly improved. ► Oxygen supply was found to be a key factor in fermentation of a newly isolated Pseudomonas sp. SJT25. ► An oxygen supply strategy was proposed and successfully applied in a bubble column bioreactor. ► The work is helpful to large scale production of the promising new antibiotic and to its future application in agriculture. A new agricultural antibiotic, 2-heptyl-5-hexylfuran-3-carboxylic acid (HHCA), was recently discovered, but its further application was limited due to its low production titer. In shake flask fermentation, the effect of initial KLa within the range of 2.12–18.87h−1 on HHCA production was investigated. The cell growth and glycerol consumption were faster at a higher initial KLa value, but the maximum production (14.43mg/L) was attained at an initial KLa value of 12.46h−1. The oxygen supply information was further applied to a 2-L bubble column bioreactor (BCB) by varying initial KLa from 1.45 to 30.18h−1, and the hyperproduction of HHCA was achieved at a relatively low initial KLa around 5–10h−1. The control of oxygen supply is considered to be an important strategy to enhance HHCA production, and the information obtained will be useful to production of this powerful new antibiotic on a large scale.
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