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Indole–porphyrin hybrids produced by metagenomics

New indole–porphyrin hybrid molecules were isolated from harboring metagenomic DNA from the Japanese marine sponge . The indole was appended to the reactive vinyl substituent of the harderoporphyrin chromophore, encoded by the insert DNA. Thus, the chimeric pathway between the heterologously express... Full description

Journal Title: Bioorganic & Medicinal Chemistry Letters 01 July 2013, Vol.23(13), pp.3810-3813
Main Author: Yang, Xiao-Long
Other Authors: Wakimoto, Toshiyuki , Takeshige, Yuya , He, Rui , Egami, Yoko , Awakawa, Takayoshi , Abe, Ikuro
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/j.bmcl.2013.04.076
Link: https://www.sciencedirect.com/science/article/pii/S0960894X13005660
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recordid: elsevier_sdoi_10_1016_j_bmcl_2013_04_076
title: Indole–porphyrin hybrids produced by metagenomics
format: Article
creator:
  • Yang, Xiao-Long
  • Wakimoto, Toshiyuki
  • Takeshige, Yuya
  • He, Rui
  • Egami, Yoko
  • Awakawa, Takayoshi
  • Abe, Ikuro
subjects:
  • Metagenome
  • Marine Sponge
  • Discodermia Calyx
  • Indole–Porphyrin Hybrid
  • Escherichia Coli
  • Medicine
  • Chemistry
  • Anatomy & Physiology
ispartof: Bioorganic & Medicinal Chemistry Letters, 01 July 2013, Vol.23(13), pp.3810-3813
description: New indole–porphyrin hybrid molecules were isolated from harboring metagenomic DNA from the Japanese marine sponge . The indole was appended to the reactive vinyl substituent of the harderoporphyrin chromophore, encoded by the insert DNA. Thus, the chimeric pathway between the heterologously expressed porphyrins and the endogenous indole generated new indole-conjugated chiral porphyrins in .
language: eng
source:
identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/j.bmcl.2013.04.076
fulltext: fulltext
issn:
  • 0960-894X
  • 0960894X
  • 1464-3405
  • 14643405
url: Link


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subjectMetagenome ; Marine Sponge ; Discodermia Calyx ; Indole–Porphyrin Hybrid ; Escherichia Coli ; Medicine ; Chemistry ; Anatomy & Physiology
descriptionNew indole–porphyrin hybrid molecules were isolated from harboring metagenomic DNA from the Japanese marine sponge . The indole was appended to the reactive vinyl substituent of the harderoporphyrin chromophore, encoded by the insert DNA. Thus, the chimeric pathway between the heterologously expressed porphyrins and the endogenous indole generated new indole-conjugated chiral porphyrins in .
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