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A new series of HAPs as anti-HBV agents targeting at capsid assembly

A series of novel Heteroaryldihydropyrimidines (HAPs) derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds were prepared from efforts to optimize an earlier series of HAPs, and compounds , , , , , and demonstrated potent inhibition of HBV DNA replica... Full description

Journal Title: Bioorganic & Medicinal Chemistry Letters 01 September 2014, Vol.24(17), pp.4247-4249
Main Author: Yang, Xiu-Yan
Other Authors: Xu, Xiao-Qian , Guan, Hua , Wang, LI-Li , Wu, Qin , Zhao, Guo-Ming , Li, Song
Format: Electronic Article Electronic Article
Language: English
Subjects:
Sec
ID: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/j.bmcl.2014.07.032
Link: https://www.sciencedirect.com/science/article/pii/S0960894X14007562
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recordid: elsevier_sdoi_10_1016_j_bmcl_2014_07_032
title: A new series of HAPs as anti-HBV agents targeting at capsid assembly
format: Article
creator:
  • Yang, Xiu-Yan
  • Xu, Xiao-Qian
  • Guan, Hua
  • Wang, LI-Li
  • Wu, Qin
  • Zhao, Guo-Ming
  • Li, Song
subjects:
  • Anti-Hbv
  • Capsid
  • Haps
  • Sec
  • Medicine
  • Chemistry
  • Anatomy & Physiology
ispartof: Bioorganic & Medicinal Chemistry Letters, 01 September 2014, Vol.24(17), pp.4247-4249
description: A series of novel Heteroaryldihydropyrimidines (HAPs) derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds were prepared from efforts to optimize an earlier series of HAPs, and compounds , , , , , and demonstrated potent inhibition of HBV DNA replication at submicromolar range.
language: eng
source:
identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/j.bmcl.2014.07.032
fulltext: fulltext
issn:
  • 0960-894X
  • 0960894X
  • 1464-3405
  • 14643405
url: Link


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descriptionA series of novel Heteroaryldihydropyrimidines (HAPs) derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds were prepared from efforts to optimize an earlier series of HAPs, and compounds , , , , , and demonstrated potent inhibition of HBV DNA replication at submicromolar range.
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