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New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth

[Display omitted] Human African trypanosomiasis (HAT), commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually. Chemotherapy, which is the main form of control against HAT has been characterized lately by the v... Full description

Journal Title: Bioorganic & medicinal chemistry letters 01 August 2015, Vol.25(15), pp.3030-3033
Main Author: Suzuki, Mitsuko
Other Authors: Tung, Nguyen Huu , Kwofie, Kofi D , Adegle, Richard , Amoa-Bosompem, Michael , Sakyiamah, Maxwell , Ayertey, Frederick , Owusu, Kofi Baffour-Awuah , Tuffour, Isaac , Atchoglo, Philip , Frempong, Kwadwo Kyereme , Anyan, William K , Uto, Takuhiro , Morinaga, Osamu , Yamashita, Taizo , Aboagye, Frederic , Appiah, Alfred Ampomah , Appiah-Opong, Regina , Nyarko, Alexander K , Yamaoka, Shoji
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/j.bmcl.2015.05.003
Link: http://dx.doi.org/10.1016/j.bmcl.2015.05.003
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recordid: elsevier_sdoi_10_1016_j_bmcl_2015_05_003
title: New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth
format: Article
creator:
  • Suzuki, Mitsuko
  • Tung, Nguyen Huu
  • Kwofie, Kofi D
  • Adegle, Richard
  • Amoa-Bosompem, Michael
  • Sakyiamah, Maxwell
  • Ayertey, Frederick
  • Owusu, Kofi Baffour-Awuah
  • Tuffour, Isaac
  • Atchoglo, Philip
  • Frempong, Kwadwo Kyereme
  • Anyan, William K
  • Uto, Takuhiro
  • Morinaga, Osamu
  • Yamashita, Taizo
  • Aboagye, Frederic
  • Appiah, Alfred Ampomah
  • Appiah-Opong, Regina
  • Nyarko, Alexander K
  • Yamaoka, Shoji
subjects:
  • Morinda Lucida
  • Tetracyclic Iridoid
  • Molucidin
  • Anti-Trypanosomal Activity
  • Medicinal Plants
  • Morinda Lucida
  • Tetracyclic Iridoid
  • Molucidin
  • Anti-Trypanosomal Activity
  • Medicinal Plants
  • Medicine
  • Chemistry
  • Anatomy & Physiology
ispartof: Bioorganic & medicinal chemistry letters, 01 August 2015, Vol.25(15), pp.3030-3033
description: [Display omitted] Human African trypanosomiasis (HAT), commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually. Chemotherapy, which is the main form of control against HAT has been characterized lately by the viewpoints of toxicity and drug resistance issues. Recently, there have been a lot of emphases on the use of medicinal plants world-wide. Morinda lucida Benth. is one of the most popular medicinal plants widely distributed in Africa and several groups have reported on its anti-protozoa activities. In this study, we have isolated one novel tetracyclic iridoid, named as molucidin, from the CHCl3 fraction of the M. lucida leaves by bioassay-guided fractionation and purification. Molucidin was structurally elucidated by 1H and 13C NMR including HMQC, HMBC, H–H COSY and NOESY resulting in tetracyclic iridoid skeleton, and its absolute configuration was determined. We...
language: eng
source:
identifier: ISSN: 0960-894X ; E-ISSN: 1464-3405 ; DOI: 10.1016/j.bmcl.2015.05.003
fulltext: fulltext
issn:
  • 0960-894X
  • 0960894X
  • 1464-3405
  • 14643405
url: Link


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titleNew anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth
creatorSuzuki, Mitsuko ; Tung, Nguyen Huu ; Kwofie, Kofi D ; Adegle, Richard ; Amoa-Bosompem, Michael ; Sakyiamah, Maxwell ; Ayertey, Frederick ; Owusu, Kofi Baffour-Awuah ; Tuffour, Isaac ; Atchoglo, Philip ; Frempong, Kwadwo Kyereme ; Anyan, William K ; Uto, Takuhiro ; Morinaga, Osamu ; Yamashita, Taizo ; Aboagye, Frederic ; Appiah, Alfred Ampomah ; Appiah-Opong, Regina ; Nyarko, Alexander K ; Yamaoka, Shoji
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subjectMorinda Lucida ; Tetracyclic Iridoid ; Molucidin ; Anti-Trypanosomal Activity ; Medicinal Plants ; Morinda Lucida ; Tetracyclic Iridoid ; Molucidin ; Anti-Trypanosomal Activity ; Medicinal Plants ; Medicine ; Chemistry ; Anatomy & Physiology
description[Display omitted] Human African trypanosomiasis (HAT), commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually. Chemotherapy, which is the main form of control against HAT has been characterized lately by the viewpoints of toxicity and drug resistance issues. Recently, there have been a lot of emphases on the use of medicinal plants world-wide. Morinda lucida Benth. is one of the most popular medicinal plants widely distributed in Africa and several groups have reported on its anti-protozoa activities. In this study, we have isolated one novel tetracyclic iridoid, named as molucidin, from the CHCl3 fraction of the M. lucida leaves by bioassay-guided fractionation and purification. Molucidin was structurally elucidated by 1H and 13C NMR including HMQC, HMBC, H–H COSY and NOESY resulting in tetracyclic iridoid skeleton, and its absolute configuration was determined. We...
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titleNew anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth
description

[Display omitted]

Human African trypanosomiasis (HAT), commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually. Chemotherapy, which is the main form of control against HAT has been characterized lately by the viewpoints of toxicity and drug resistance issues. Recently, there have been a lot of emphases on the use of medicinal plants world-wide. Morinda lucida Benth. is one of the most popular medicinal plants widely distributed in Africa and several groups have reported on its anti-protozoa activities. In this study, we have isolated one novel tetracyclic iridoid, named as molucidin, from the CHCl3 fraction of the M. lucida leaves by bioassay-guided fractionation and purification. Molucidin was structurally elucidated by 1H and 13C NMR including HMQC, HMBC, H–H COSY and NOESY resulting in tetracyclic iridoid skeleton, and its absolute configuration was determined. We...

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abstract

[Display omitted]

Human African trypanosomiasis (HAT), commonly known as sleeping sickness has remained a serious health problem in many African countries with thousands of new infected cases annually. Chemotherapy, which is the main form of control against HAT has been characterized lately by the viewpoints of toxicity and drug resistance issues. Recently, there have been a lot of emphases on the use of medicinal plants world-wide. Morinda lucida Benth. is one of the most popular medicinal plants widely distributed in Africa and several groups have reported on its anti-protozoa activities. In this study, we have isolated one novel tetracyclic iridoid, named as molucidin, from the CHCl3 fraction of the M. lucida leaves by bioassay-guided fractionation and purification. Molucidin was structurally elucidated by 1H and 13C NMR including HMQC, HMBC, H–H COSY and NOESY resulting in tetracyclic iridoid skeleton, and its absolute configuration was determined. We...

pubElsevier Ltd
doi10.1016/j.bmcl.2015.05.003
lad01Bioorganic & medicinal chemistry letters
date2015-08-01