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Neuroprotective effects of exogenous methane in a rat model of acute carbon monoxide poisoning

Delayed neuropsychological sequelae (DNS) are the most common and serious effects of severe carbon monoxide (CO) poisoning, occurring in approximately half of all CO poisoning cases. Growing evidence suggests that oxidative stress and secondary reactions in delayed brain injury are crucial to CO tox... Full description

Journal Title: Brain Research 15 February 2016, Vol.1633, pp.62-72
Main Author: Fan, Dan-Feng
Other Authors: Hu, Hui-Jun , Sun, Qiang , Lv, Yan , Ye, Zhou-Heng , Sun, Xue-Jun , Pan, Shu-Yi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-8993 ; E-ISSN: 1872-6240 ; DOI: 10.1016/j.brainres.2015.12.019
Link: https://www.sciencedirect.com/science/article/pii/S0006899315009580
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recordid: elsevier_sdoi_10_1016_j_brainres_2015_12_019
title: Neuroprotective effects of exogenous methane in a rat model of acute carbon monoxide poisoning
format: Article
creator:
  • Fan, Dan-Feng
  • Hu, Hui-Jun
  • Sun, Qiang
  • Lv, Yan
  • Ye, Zhou-Heng
  • Sun, Xue-Jun
  • Pan, Shu-Yi
subjects:
  • Methane
  • Carbon Monoxide Poisoning
  • Neuroprotection
  • Oxidative Stress
  • Apoptosis
  • Anatomy & Physiology
ispartof: Brain Research, 15 February 2016, Vol.1633, pp.62-72
description: Delayed neuropsychological sequelae (DNS) are the most common and serious effects of severe carbon monoxide (CO) poisoning, occurring in approximately half of all CO poisoning cases. Growing evidence suggests that oxidative stress and secondary reactions in delayed brain injury are crucial to CO toxicity, similar to ischaemia–reperfusion injury. Exogenous methane plays a protective role in ischaemia–reperfusion injury by affecting key events through anti-oxidant, anti-inflammatory, and anti-apoptosis actions. Our study aimed to explore the potential of exogenous methane to relieve the severity of DNS. Thirty-six male Sprague–Dawley (SD) rats were divided into three groups of normal-, CO- and CO plus methane-treated rats. The rats in the latter two groups were exposed to 1000 ppm CO for 40 min and then to 3000 ppm CO for another 20 min. Following CO exposure, saline or methane saline...
language: eng
source:
identifier: ISSN: 0006-8993 ; E-ISSN: 1872-6240 ; DOI: 10.1016/j.brainres.2015.12.019
fulltext: fulltext
issn:
  • 0006-8993
  • 00068993
  • 1872-6240
  • 18726240
url: Link


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titleNeuroprotective effects of exogenous methane in a rat model of acute carbon monoxide poisoning
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subjectMethane ; Carbon Monoxide Poisoning ; Neuroprotection ; Oxidative Stress ; Apoptosis ; Anatomy & Physiology
descriptionDelayed neuropsychological sequelae (DNS) are the most common and serious effects of severe carbon monoxide (CO) poisoning, occurring in approximately half of all CO poisoning cases. Growing evidence suggests that oxidative stress and secondary reactions in delayed brain injury are crucial to CO toxicity, similar to ischaemia–reperfusion injury. Exogenous methane plays a protective role in ischaemia–reperfusion injury by affecting key events through anti-oxidant, anti-inflammatory, and anti-apoptosis actions. Our study aimed to explore the potential of exogenous methane to relieve the severity of DNS. Thirty-six male Sprague–Dawley (SD) rats were divided into three groups of normal-, CO- and CO plus methane-treated rats. The rats in the latter two groups were exposed to 1000 ppm CO for 40 min and then to 3000 ppm CO for another 20 min. Following CO exposure, saline or methane saline...
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