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Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promote... Full description

Journal Title: Cancer Letters 2012, Vol.315(1), pp.28-37
Main Author: Zhu, Wei
Other Authors: Huang, Ling , Li, Yahong , Zhang, Xu , Gu, Jianmei , Yan, Yongmin , Xu, Xiaomeng , Wang, Mei , Qian, Hui , Xu, Wenrong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0304-3835 ; E-ISSN: 1872-7980 ; DOI: 10.1016/j.canlet.2011.10.002
Link: http://dx.doi.org/10.1016/j.canlet.2011.10.002
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recordid: elsevier_sdoi_10_1016_j_canlet_2011_10_002
title: Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
format: Article
creator:
  • Zhu, Wei
  • Huang, Ling
  • Li, Yahong
  • Zhang, Xu
  • Gu, Jianmei
  • Yan, Yongmin
  • Xu, Xiaomeng
  • Wang, Mei
  • Qian, Hui
  • Xu, Wenrong
subjects:
  • Mesenchymal Stem Cell
  • Exosome
  • Tumor Growth
  • Xenograft Model
  • Mapk Pathway
  • Mscs
  • Hgc-Mscs
  • Msc-Exosomes
  • Mapk
  • Erk1/2
  • Vegf
  • Α-Sma
  • Cxcr4
  • Pcna
  • Mesenchymal Stem Cell
  • Exosome
  • Tumor Growth
  • Xenograft Model
  • Mapk Pathway
ispartof: Cancer Letters, 2012, Vol.315(1), pp.28-37
description: Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell–cell interactions may contribute to tumor progression.
language: eng
source:
identifier: ISSN: 0304-3835 ; E-ISSN: 1872-7980 ; DOI: 10.1016/j.canlet.2011.10.002
fulltext: fulltext
issn:
  • 0304-3835
  • 03043835
  • 1872-7980
  • 18727980
url: Link


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titleExosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
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ispartofCancer Letters, 2012, Vol.315(1), pp.28-37
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subjectMesenchymal Stem Cell ; Exosome ; Tumor Growth ; Xenograft Model ; Mapk Pathway ; Mscs ; Hgc-Mscs ; Msc-Exosomes ; Mapk ; Erk1/2 ; Vegf ; Α-Sma ; Cxcr4 ; Pcna ; Mesenchymal Stem Cell ; Exosome ; Tumor Growth ; Xenograft Model ; Mapk Pathway
descriptionMesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell–cell interactions may contribute to tumor progression.
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Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell–cell interactions may contribute to tumor progression.

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Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell–cell interactions may contribute to tumor progression.

pubElsevier Ireland Ltd
doi10.1016/j.canlet.2011.10.002
lad01Cancer Letters