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Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy

Selective targeting to the tumor niche remains a major challenge in successful cancer therapy. Somatostatin receptor 2 (SSTR2) is overexpressed in breast cancer cells thus making this receptor an attractive target for selective guidance of ligand-conjugated drug liposomes to the tumor site. In this... Full description

Journal Title: Cancer Letters 01 March 2017, Vol.388, pp.292-302
Main Author: Bharti, Rashmi
Other Authors: Dey, Goutam , Banerjee, Indranil , Dey, Kaushik Kumar , Parida, Sheetal , Kumar, B.N. Prashanth , Das, Chandan Kanta , Pal, Ipsita , Mukherjee, Manabendra , Misra, Mridula , Pradhan, Anjan K , Emdad, Luni , Das, Swadesh K , Fisher, Paul B , Mandal, Mahitosh
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0304-3835 ; E-ISSN: 1872-7980 ; DOI: 10.1016/j.canlet.2016.12.021
Link: https://www.sciencedirect.com/science/article/pii/S0304383516307844
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recordid: elsevier_sdoi_10_1016_j_canlet_2016_12_021
title: Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy
format: Article
creator:
  • Bharti, Rashmi
  • Dey, Goutam
  • Banerjee, Indranil
  • Dey, Kaushik Kumar
  • Parida, Sheetal
  • Kumar, B.N. Prashanth
  • Das, Chandan Kanta
  • Pal, Ipsita
  • Mukherjee, Manabendra
  • Misra, Mridula
  • Pradhan, Anjan K
  • Emdad, Luni
  • Das, Swadesh K
  • Fisher, Paul B
  • Mandal, Mahitosh
subjects:
  • Liposome
  • Somatostatin Analogue (Sst)
  • Diacerein and Breast Cancer
  • Medicine
ispartof: Cancer Letters, 01 March 2017, Vol.388, pp.292-302
description: Selective targeting to the tumor niche remains a major challenge in successful cancer therapy. Somatostatin receptor 2 (SSTR2) is overexpressed in breast cancer cells thus making this receptor an attractive target for selective guidance of ligand-conjugated drug liposomes to the tumor site. In this study, a synthetic somatostatin analogue (SST) was used as SSTR2 targeting agent and Diacerein was employed as therapeutic molecule. Diacerein loaded liposomes (DNL) were prepared and they were further decorated with the synthetic and stable analogue of somatostatin (SST-DNL). Fabricated liposomes were nano-size in range and biocompatible. SST-DNL displayed significantly better anti-tumor efficacy as compared to free Diacerein (DN) and DNL in breast cancer models. Enhanced apoptosis in breast cancer cells was detected in SST-DNL treated groups as monitored by cell cycle analysis and changes in expression level of apoptotic/anti-apoptotic proteins Bcl-2, Bax, cleaved Caspase 3 and PARP....
language: eng
source:
identifier: ISSN: 0304-3835 ; E-ISSN: 1872-7980 ; DOI: 10.1016/j.canlet.2016.12.021
fulltext: fulltext
issn:
  • 0304-3835
  • 03043835
  • 1872-7980
  • 18727980
url: Link


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titleSomatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy
creatorBharti, Rashmi ; Dey, Goutam ; Banerjee, Indranil ; Dey, Kaushik Kumar ; Parida, Sheetal ; Kumar, B.N. Prashanth ; Das, Chandan Kanta ; Pal, Ipsita ; Mukherjee, Manabendra ; Misra, Mridula ; Pradhan, Anjan K ; Emdad, Luni ; Das, Swadesh K ; Fisher, Paul B ; Mandal, Mahitosh
ispartofCancer Letters, 01 March 2017, Vol.388, pp.292-302
identifier
subjectLiposome ; Somatostatin Analogue (Sst) ; Diacerein and Breast Cancer ; Medicine
descriptionSelective targeting to the tumor niche remains a major challenge in successful cancer therapy. Somatostatin receptor 2 (SSTR2) is overexpressed in breast cancer cells thus making this receptor an attractive target for selective guidance of ligand-conjugated drug liposomes to the tumor site. In this study, a synthetic somatostatin analogue (SST) was used as SSTR2 targeting agent and Diacerein was employed as therapeutic molecule. Diacerein loaded liposomes (DNL) were prepared and they were further decorated with the synthetic and stable analogue of somatostatin (SST-DNL). Fabricated liposomes were nano-size in range and biocompatible. SST-DNL displayed significantly better anti-tumor efficacy as compared to free Diacerein (DN) and DNL in breast cancer models. Enhanced apoptosis in breast cancer cells was detected in SST-DNL treated groups as monitored by cell cycle analysis and changes in expression level of apoptotic/anti-apoptotic proteins Bcl-2, Bax, cleaved Caspase 3 and PARP....
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Selective targeting to the tumor niche remains a major challenge in successful cancer therapy. Somatostatin receptor 2 (SSTR2) is overexpressed in breast cancer cells thus making this receptor an attractive target for selective guidance of ligand-conjugated drug liposomes to the tumor site. In this study, a synthetic somatostatin analogue (SST) was used as SSTR2 targeting agent and Diacerein was employed as therapeutic molecule. Diacerein loaded liposomes (DNL) were prepared and they were further decorated with the synthetic and stable analogue of somatostatin (SST-DNL). Fabricated liposomes were nano-size in range and biocompatible. SST-DNL displayed significantly better anti-tumor efficacy as compared to free Diacerein (DN) and DNL in breast cancer models. Enhanced apoptosis in breast cancer cells was detected in SST-DNL treated groups as monitored by cell cycle analysis and changes in expression level of apoptotic/anti-apoptotic proteins Bcl-2, Bax, cleaved Caspase 3 and PARP....

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Selective targeting to the tumor niche remains a major challenge in successful cancer therapy. Somatostatin receptor 2 (SSTR2) is overexpressed in breast cancer cells thus making this receptor an attractive target for selective guidance of ligand-conjugated drug liposomes to the tumor site. In this study, a synthetic somatostatin analogue (SST) was used as SSTR2 targeting agent and Diacerein was employed as therapeutic molecule. Diacerein loaded liposomes (DNL) were prepared and they were further decorated with the synthetic and stable analogue of somatostatin (SST-DNL). Fabricated liposomes were nano-size in range and biocompatible. SST-DNL displayed significantly better anti-tumor efficacy as compared to free Diacerein (DN) and DNL in breast cancer models. Enhanced apoptosis in breast cancer cells was detected in SST-DNL treated groups as monitored by cell cycle analysis and changes in expression level of apoptotic/anti-apoptotic proteins Bcl-2, Bax, cleaved Caspase 3 and PARP....

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date2017-03-01