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Screening and verifying endometrial carcinoma diagnostic biomarkers based on a urine metabolomic profiling study using UPLC-Q-TOF/MS

Endometrial carcinoma (EOC) is a gynecological disease with one of the highest worldwide incidences. Due to the lack of typical clinical symptoms and limited sensitive screening methods used to diagnose endometrial carcinoma, the disease is easily neglected before patients are aware of its presence.... Full description

Journal Title: Clinica Chimica Acta 01 December 2016, Vol.463, pp.200-206
Main Author: Shao, Xidong
Other Authors: Wang, Ke , Liu, Xinyu , Gu, Caiyun , Zhang, Pengjie , Xie, Jiabin , Liu, Wenxin , Sun, Lu , Chen, Tong , Li, Yubo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0009-8981 ; E-ISSN: 1873-3492 ; DOI: 10.1016/j.cca.2016.10.027
Link: https://www.sciencedirect.com/science/article/pii/S0009898116304363
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recordid: elsevier_sdoi_10_1016_j_cca_2016_10_027
title: Screening and verifying endometrial carcinoma diagnostic biomarkers based on a urine metabolomic profiling study using UPLC-Q-TOF/MS
format: Article
creator:
  • Shao, Xidong
  • Wang, Ke
  • Liu, Xinyu
  • Gu, Caiyun
  • Zhang, Pengjie
  • Xie, Jiabin
  • Liu, Wenxin
  • Sun, Lu
  • Chen, Tong
  • Li, Yubo
subjects:
  • Metabolomics
  • Endometrial Carcinoma
  • Diagnostic Biomarkers
  • Medicine
  • Chemistry
ispartof: Clinica Chimica Acta, 01 December 2016, Vol.463, pp.200-206
description: Endometrial carcinoma (EOC) is a gynecological disease with one of the highest worldwide incidences. Due to the lack of typical clinical symptoms and limited sensitive screening methods used to diagnose endometrial carcinoma, the disease is easily neglected before patients are aware of its presence. Therefore, EOC results in serious impacts on women's lives and health. We screened diagnostic biomarkers of EOC with a noninvasive method that compared healthy individuals and endometrial hyperplasia (EOH) patients. The morning urine of 25 healthy individuals, 25 patients with EOC and 10 patients with EOH were analyzed using an ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) platform. Metabolomics data were used to screen the different metabolites according to principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) analyses. Furthermore, the screened biomarkers of the newly diagnosed...
language: eng
source:
identifier: ISSN: 0009-8981 ; E-ISSN: 1873-3492 ; DOI: 10.1016/j.cca.2016.10.027
fulltext: fulltext
issn:
  • 0009-8981
  • 00098981
  • 1873-3492
  • 18733492
url: Link


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titleScreening and verifying endometrial carcinoma diagnostic biomarkers based on a urine metabolomic profiling study using UPLC-Q-TOF/MS
creatorShao, Xidong ; Wang, Ke ; Liu, Xinyu ; Gu, Caiyun ; Zhang, Pengjie ; Xie, Jiabin ; Liu, Wenxin ; Sun, Lu ; Chen, Tong ; Li, Yubo
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subjectMetabolomics ; Endometrial Carcinoma ; Diagnostic Biomarkers ; Medicine ; Chemistry
descriptionEndometrial carcinoma (EOC) is a gynecological disease with one of the highest worldwide incidences. Due to the lack of typical clinical symptoms and limited sensitive screening methods used to diagnose endometrial carcinoma, the disease is easily neglected before patients are aware of its presence. Therefore, EOC results in serious impacts on women's lives and health. We screened diagnostic biomarkers of EOC with a noninvasive method that compared healthy individuals and endometrial hyperplasia (EOH) patients. The morning urine of 25 healthy individuals, 25 patients with EOC and 10 patients with EOH were analyzed using an ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) platform. Metabolomics data were used to screen the different metabolites according to principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) analyses. Furthermore, the screened biomarkers of the newly diagnosed...
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titleScreening and verifying endometrial carcinoma diagnostic biomarkers based on a urine metabolomic profiling study using UPLC-Q-TOF/MS
description

Endometrial carcinoma (EOC) is a gynecological disease with one of the highest worldwide incidences. Due to the lack of typical clinical symptoms and limited sensitive screening methods used to diagnose endometrial carcinoma, the disease is easily neglected before patients are aware of its presence. Therefore, EOC results in serious impacts on women's lives and health. We screened diagnostic biomarkers of EOC with a noninvasive method that compared healthy individuals and endometrial hyperplasia (EOH) patients.

The morning urine of 25 healthy individuals, 25 patients with EOC and 10 patients with EOH were analyzed using an ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) platform. Metabolomics data were used to screen the different metabolites according to principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) analyses. Furthermore, the screened biomarkers of the newly diagnosed...

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Endometrial carcinoma (EOC) is a gynecological disease with one of the highest worldwide incidences. Due to the lack of typical clinical symptoms and limited sensitive screening methods used to diagnose endometrial carcinoma, the disease is easily neglected before patients are aware of its presence. Therefore, EOC results in serious impacts on women's lives and health. We screened diagnostic biomarkers of EOC with a noninvasive method that compared healthy individuals and endometrial hyperplasia (EOH) patients.

The morning urine of 25 healthy individuals, 25 patients with EOC and 10 patients with EOH were analyzed using an ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) platform. Metabolomics data were used to screen the different metabolites according to principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) analyses. Furthermore, the screened biomarkers of the newly diagnosed...

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