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By Hook or by Crook: Multifaceted DNA-Binding Properties of MeCP2

Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interac... Full description

Journal Title: Cell 28 February 2013, Vol.152(5), pp.940-942
Main Author: Shin, Jaehoon
Other Authors: Ming, Guo-Li , Song, Hongjun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0092-8674 ; E-ISSN: 1097-4172 ; DOI: 10.1016/j.cell.2013.02.017
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recordid: elsevier_sdoi_10_1016_j_cell_2013_02_017
title: By Hook or by Crook: Multifaceted DNA-Binding Properties of MeCP2
format: Article
creator:
  • Shin, Jaehoon
  • Ming, Guo-Li
  • Song, Hongjun
subjects:
  • Biology
ispartof: Cell, 28 February 2013, Vol.152(5), pp.940-942
description: Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.
language: eng
source:
identifier: ISSN: 0092-8674 ; E-ISSN: 1097-4172 ; DOI: 10.1016/j.cell.2013.02.017
fulltext: fulltext
issn:
  • 0092-8674
  • 00928674
  • 1097-4172
  • 10974172
url: Link


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descriptionTwo new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.
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Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.

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