schliessen

Filtern

 

Bibliotheken

A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence

Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We... Full description

Journal Title: Cell Reports 10 April 2018, Vol.23(2), pp.637-651
Main Author: de Souza, Camila Ferreira
Other Authors: Sabedot, Thais S , Malta, Tathiane M , Stetson, Lindsay , Morozova, Olena , Sokolov, Artem , Laird, Peter W , Wiznerowicz, Maciej , Iavarone, Antonio , Snyder, James , Decarvalho, Ana , Sanborn, Zachary , Mcdonald, Kerrie L , Friedman, William A , Tirapelli, Daniela , Poisson, Laila , Mikkelsen, Tom , Carlotti, Carlos G , Kalkanis, Steven , Zenklusen, Jean
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 2211-1247 ; E-ISSN: 2211-1247 ; DOI: 10.1016/j.celrep.2018.03.107
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_celrep_2018_03_107
title: A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
format: Article
creator:
  • de Souza, Camila Ferreira
  • Sabedot, Thais S
  • Malta, Tathiane M
  • Stetson, Lindsay
  • Morozova, Olena
  • Sokolov, Artem
  • Laird, Peter W
  • Wiznerowicz, Maciej
  • Iavarone, Antonio
  • Snyder, James
  • Decarvalho, Ana
  • Sanborn, Zachary
  • Mcdonald, Kerrie L
  • Friedman, William A
  • Tirapelli, Daniela
  • Poisson, Laila
  • Mikkelsen, Tom
  • Carlotti, Carlos G
  • Kalkanis, Steven
  • Zenklusen, Jean
subjects:
  • Longitudinal Gliomas
  • DNA Methylation
  • Idh Mutation
  • G-Cimp-High
  • Intra-Subtype Heterogeneity
  • Malignant Transformation and Recurrence
  • G-Cimp-Low
  • Stem Cell-Like Glioblastoma
  • Predictive Biomarkers
  • Longitudinal Gliomas
  • DNA Methylation
  • Idh Mutation
  • G-Cimp-High
  • Intra-Subtype Heterogeneity
  • Malignant Transformation and Recurrence
  • G-Cimp-Low
  • Stem Cell-Like Glioblastoma
  • Predictive Biomarkers
  • Biology
ispartof: Cell Reports, 10 April 2018, Vol.23(2), pp.637-651
description: Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We previously reported that the IDH mutant G-CIMP-high subtype would be a predecessor to the G-CIMP-low subtype. Here, we performed a comprehensive DNA methylation longitudinal analysis of diffuse gliomas from 77 patients (200 tumors) to enlighten the epigenome-based malignant transformation of initially lower-grade gliomas. Intra-subtype heterogeneity among G-CIMP-high primary tumors allowed us to identify predictive biomarkers for assessing the risk of malignant recurrence at early stages of disease. G-CIMP-low recurrence appeared in 9.5% of all gliomas, and these resembled IDH-wild-type primary glioblastoma. G-CIMP-low recurrence can be characterized by distinct epigenetic changes...
language: eng
source:
identifier: ISSN: 2211-1247 ; E-ISSN: 2211-1247 ; DOI: 10.1016/j.celrep.2018.03.107
fulltext: fulltext
issn:
  • 2211-1247
  • 22111247
url: Link


@attributes
ID60608613
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_celrep_2018_03_107
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_celrep_2018_03_107
sourcesystemPC
dbid
00SF
1457
26I.
3AAEDT
4AAFTH
5AAKRW
6AAXJY
7AFTJW
8AGHFR
9AITUG
10ALKID
11FDB
12IXB
13SSZ
pqid2024466538
display
typearticle
titleA Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
creatorde Souza, Camila Ferreira ; Sabedot, Thais S ; Malta, Tathiane M ; Stetson, Lindsay ; Morozova, Olena ; Sokolov, Artem ; Laird, Peter W ; Wiznerowicz, Maciej ; Iavarone, Antonio ; Snyder, James ; Decarvalho, Ana ; Sanborn, Zachary ; Mcdonald, Kerrie L ; Friedman, William A ; Tirapelli, Daniela ; Poisson, Laila ; Mikkelsen, Tom ; Carlotti, Carlos G ; Kalkanis, Steven ; Zenklusen, Jean
ispartofCell Reports, 10 April 2018, Vol.23(2), pp.637-651
identifier
subjectLongitudinal Gliomas ; DNA Methylation ; Idh Mutation ; G-Cimp-High ; Intra-Subtype Heterogeneity ; Malignant Transformation and Recurrence ; G-Cimp-Low ; Stem Cell-Like Glioblastoma ; Predictive Biomarkers ; Longitudinal Gliomas ; DNA Methylation ; Idh Mutation ; G-Cimp-High ; Intra-Subtype Heterogeneity ; Malignant Transformation and Recurrence ; G-Cimp-Low ; Stem Cell-Like Glioblastoma ; Predictive Biomarkers ; Biology
descriptionGlioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We previously reported that the IDH mutant G-CIMP-high subtype would be a predecessor to the G-CIMP-low subtype. Here, we performed a comprehensive DNA methylation longitudinal analysis of diffuse gliomas from 77 patients (200 tumors) to enlighten the epigenome-based malignant transformation of initially lower-grade gliomas. Intra-subtype heterogeneity among G-CIMP-high primary tumors allowed us to identify predictive biomarkers for assessing the risk of malignant recurrence at early stages of disease. G-CIMP-low recurrence appeared in 9.5% of all gliomas, and these resembled IDH-wild-type primary glioblastoma. G-CIMP-low recurrence can be characterized by distinct epigenetic changes...
languageeng
oafree_for_read
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
linktorsrc$$Uhttp://dx.doi.org/10.1016/j.celrep.2018.03.107$$EView_full_text_in_ScienceDirect
search
creatorcontrib
0de Souza, Camila Ferreira
1Sabedot, Thais S
2Malta, Tathiane M
3Stetson, Lindsay
4Morozova, Olena
5Sokolov, Artem
6Laird, Peter W
7Wiznerowicz, Maciej
8Iavarone, Antonio
9Snyder, James
10Decarvalho, Ana
11Sanborn, Zachary
12Mcdonald, Kerrie L
13Friedman, William A
14Tirapelli, Daniela
15Poisson, Laila
16Mikkelsen, Tom
17Carlotti, Carlos G
18Kalkanis, Steven
19Zenklusen, Jean
titleA Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
description

Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We previously reported that the IDH mutant G-CIMP-high subtype would be a predecessor to the G-CIMP-low subtype. Here, we performed a comprehensive DNA methylation longitudinal analysis of diffuse gliomas from 77 patients (200 tumors) to enlighten the epigenome-based malignant transformation of initially lower-grade gliomas. Intra-subtype heterogeneity among G-CIMP-high primary tumors allowed us to identify predictive biomarkers for assessing the risk of malignant recurrence at early stages of disease. G-CIMP-low recurrence appeared in 9.5% of all gliomas, and these resembled IDH-wild-type primary glioblastoma. G-CIMP-low recurrence can be characterized by distinct epigenetic changes...

subject
0Longitudinal Gliomas
1DNA Methylation
2Idh Mutation
3G-Cimp-High
4Intra-Subtype Heterogeneity
5Malignant Transformation and Recurrence
6G-Cimp-Low
7Stem Cell-Like Glioblastoma
8Predictive Biomarkers
9Biology
general
0English
1Elsevier Inc
210.1016/j.celrep.2018.03.107
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_celrep_2018_03_107
issn
02211-1247
122111247
rsrctypearticle
creationdate2018
addtitleCell Reports
searchscope
0elsevier_full
1elsevier4
2elsevier2
scope
0elsevier_full
1elsevier4
2elsevier2
lsr45$$EView_full_text_in_ScienceDirect
tmp01ScienceDirect Journals (Elsevier)
tmp02
00SF
1457
26I.
3AAEDT
4AAFTH
5AAKRW
6AAXJY
7AFTJW
8AGHFR
9AITUG
10ALKID
11FDB
12IXB
13SSZ
orcidid0000-0003-4051-8114
startdate20180410
enddate20180410
lsr40Cell Reports, 10 April 2018, Vol.23 (2), pp.637-651
doi10.1016/j.celrep.2018.03.107
citationpf 637 pt 651 vol 23 issue 2
lsr30VSR-Enriched:[pqid]
sort
titleA Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
authorde Souza, Camila Ferreira ; Sabedot, Thais S ; Malta, Tathiane M ; Stetson, Lindsay ; Morozova, Olena ; Sokolov, Artem ; Laird, Peter W ; Wiznerowicz, Maciej ; Iavarone, Antonio ; Snyder, James ; Decarvalho, Ana ; Sanborn, Zachary ; Mcdonald, Kerrie L ; Friedman, William A ; Tirapelli, Daniela ; Poisson, Laila ; Mikkelsen, Tom ; Carlotti, Carlos G ; Kalkanis, Steven ; Zenklusen, Jean
creationdate20180410
lso0120180410
facets
frbrgroupid6463630286189664364
frbrtype5
newrecords20190904
languageeng
topic
0Longitudinal Gliomas
1DNA Methylation
2Idh Mutation
3G-Cimp-High
4Intra-Subtype Heterogeneity
5Malignant Transformation and Recurrence
6G-Cimp-Low
7Stem Cell-Like Glioblastoma
8Predictive Biomarkers
9Biology
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0de Souza, Camila Ferreira
1Sabedot, Thais S
2Malta, Tathiane M
3Stetson, Lindsay
4Morozova, Olena
5Sokolov, Artem
6Laird, Peter W
7Wiznerowicz, Maciej
8Iavarone, Antonio
9Snyder, James
10Decarvalho, Ana
11Sanborn, Zachary
12Mcdonald, Kerrie L
13Friedman, William A
14Tirapelli, Daniela
15Poisson, Laila
16Mikkelsen, Tom
17Carlotti, Carlos G
18Kalkanis, Steven
19Zenklusen, Jean
jtitleCell Reports
creationdate2018
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
orcidid0000-0003-4051-8114
aulast
0de Souza
1Sabedot
2Malta
3Stetson
4Morozova
5Sokolov
6Laird
7Wiznerowicz
8Iavarone
9Snyder
10Decarvalho
11Sanborn
12Mcdonald
13Friedman
14Tirapelli
15Poisson
16Mikkelsen
17Carlotti
18Kalkanis
19Zenklusen
aufirst
0Camila Ferreira
1Thais S
2Tathiane M
3Lindsay
4Olena
5Artem
6Peter W
7Maciej
8Antonio
9James
10Ana
11Zachary
12Kerrie L
13William A
14Daniela
15Laila
16Tom
17Carlos G
18Steven
19Jean
auinitC
auinit1C
au
0de Souza, Camila Ferreira
1Sabedot, Thais S
2Malta, Tathiane M
3Stetson, Lindsay
4Morozova, Olena
5Sokolov, Artem
6Laird, Peter W
7Wiznerowicz, Maciej
8Iavarone, Antonio
9Snyder, James
10Decarvalho, Ana
11Sanborn, Zachary
12Mcdonald, Kerrie L
13Friedman, William A
14Tirapelli, Daniela
15Poisson, Laila
16Mikkelsen, Tom
17Carlotti, Carlos G
18Kalkanis, Steven
19Zenklusen, Jean
atitleA Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
jtitleCell Reports
risdate20180410
volume23
issue2
spage637
epage651
pages637-651
issn2211-1247
eissn2211-1247
formatjournal
genrearticle
ristypeJOUR
abstract

Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We previously reported that the IDH mutant G-CIMP-high subtype would be a predecessor to the G-CIMP-low subtype. Here, we performed a comprehensive DNA methylation longitudinal analysis of diffuse gliomas from 77 patients (200 tumors) to enlighten the epigenome-based malignant transformation of initially lower-grade gliomas. Intra-subtype heterogeneity among G-CIMP-high primary tumors allowed us to identify predictive biomarkers for assessing the risk of malignant recurrence at early stages of disease. G-CIMP-low recurrence appeared in 9.5% of all gliomas, and these resembled IDH-wild-type primary glioblastoma. G-CIMP-low recurrence can be characterized by distinct epigenetic changes...

pubElsevier Inc
doi10.1016/j.celrep.2018.03.107
lad01Cell Reports
oafree_for_read
date2018-04-10