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Diagnostic accuracy of BNP and NT-proBNP in patients presenting to acute care settings with dyspnea: A systematic review

We sought to compare the diagnostic performance of B-type natriuretic peptide (BNP) and N-terminal proBNP measurements in patients presenting to acute care settings with dyspnea, a common presenting symptom of heart failure. We conducted a systematic review of the literature. For all included studie... Full description

Journal Title: Clinical Biochemistry 2008, Vol.41(4), pp.250-259
Main Author: Worster, Andrew
Other Authors: Balion, Cynthia M , Hill, Stephen A , Santaguida, Pasqualina , Ismaila, Afisi , Mckelvie, Robert , Reichert, Sonja M , Mcqueen, Matthew J , Booker, Lynda , Raina, Parminder S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Bnp
Bnp
ID: ISSN: 0009-9120 ; E-ISSN: 1873-2933 ; DOI: 10.1016/j.clinbiochem.2007.08.008
Link: http://dx.doi.org/10.1016/j.clinbiochem.2007.08.008
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recordid: elsevier_sdoi_10_1016_j_clinbiochem_2007_08_008
title: Diagnostic accuracy of BNP and NT-proBNP in patients presenting to acute care settings with dyspnea: A systematic review
format: Article
creator:
  • Worster, Andrew
  • Balion, Cynthia M
  • Hill, Stephen A
  • Santaguida, Pasqualina
  • Ismaila, Afisi
  • Mckelvie, Robert
  • Reichert, Sonja M
  • Mcqueen, Matthew J
  • Booker, Lynda
  • Raina, Parminder S
subjects:
  • B-Type Natriuretic Peptide
  • Bnp
  • NT-Probnp
  • Emergency Department
  • Urgent Care
  • Systematic Review
  • Meta-Analysis
  • Diagnosis
  • B-Type Natriuretic Peptide
  • Bnp
  • NT-Probnp
  • Emergency Department
  • Urgent Care
  • Systematic Review
  • Meta-Analysis
  • Diagnosis
  • Medicine
  • Chemistry
ispartof: Clinical Biochemistry, 2008, Vol.41(4), pp.250-259
description: We sought to compare the diagnostic performance of B-type natriuretic peptide (BNP) and N-terminal proBNP measurements in patients presenting to acute care settings with dyspnea, a common presenting symptom of heart failure. We conducted a systematic review of the literature. For all included studies, we applied the QUADAS 14-question quality assessment tool for systematic reviews of diagnostic accuracy and abstracted the data for every published cut point. We screened 4338 studies and included nine in the meta-analysis. All 9 studies scored positively on at least 50% of the QUADAS questions. The pooled estimates of sensitivity and specificity were the same for the BNP studies (0.97 (95% CI: 0.96, 0.98) and 0.70 (95% CI: 0.56, 0.85)) as for the NT-proBNP studies (0.95 (95% CI: 0.90, 1.01) and 0.72 (95% CI: 0.53, 0.90)). Tests for heterogeneity were significant in both subgroups: BNP ( I 2 = 97.9%, p 0.001) and NT-proBNP...
language: eng
source:
identifier: ISSN: 0009-9120 ; E-ISSN: 1873-2933 ; DOI: 10.1016/j.clinbiochem.2007.08.008
fulltext: fulltext
issn:
  • 0009-9120
  • 00099120
  • 1873-2933
  • 18732933
url: Link


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titleDiagnostic accuracy of BNP and NT-proBNP in patients presenting to acute care settings with dyspnea: A systematic review
creatorWorster, Andrew ; Balion, Cynthia M ; Hill, Stephen A ; Santaguida, Pasqualina ; Ismaila, Afisi ; Mckelvie, Robert ; Reichert, Sonja M ; Mcqueen, Matthew J ; Booker, Lynda ; Raina, Parminder S
ispartofClinical Biochemistry, 2008, Vol.41(4), pp.250-259
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subjectB-Type Natriuretic Peptide ; Bnp ; NT-Probnp ; Emergency Department ; Urgent Care ; Systematic Review ; Meta-Analysis ; Diagnosis ; B-Type Natriuretic Peptide ; Bnp ; NT-Probnp ; Emergency Department ; Urgent Care ; Systematic Review ; Meta-Analysis ; Diagnosis ; Medicine ; Chemistry
descriptionWe sought to compare the diagnostic performance of B-type natriuretic peptide (BNP) and N-terminal proBNP measurements in patients presenting to acute care settings with dyspnea, a common presenting symptom of heart failure. We conducted a systematic review of the literature. For all included studies, we applied the QUADAS 14-question quality assessment tool for systematic reviews of diagnostic accuracy and abstracted the data for every published cut point. We screened 4338 studies and included nine in the meta-analysis. All 9 studies scored positively on at least 50% of the QUADAS questions. The pooled estimates of sensitivity and specificity were the same for the BNP studies (0.97 (95% CI: 0.96, 0.98) and 0.70 (95% CI: 0.56, 0.85)) as for the NT-proBNP studies (0.95 (95% CI: 0.90, 1.01) and 0.72 (95% CI: 0.53, 0.90)). Tests for heterogeneity were significant in both subgroups: BNP ( I 2 = 97.9%, p 0.001) and NT-proBNP...
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