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Evidence for the use of B-type natriuretic peptides for screening asymptomatic populations and for diagnosis in primary care

To determine the screening and diagnostic properties of BNP and NT-proBNP for heart failure in primary care. We conducted a systematic review of randomized control trials and observational (cohort or case–control) studies of heart failure detection using B-type natriuretic peptides published in Engl... Full description

Journal Title: Clinical Biochemistry 2008, Vol.41(4), pp.240-249
Main Author: Hill, Stephen A
Other Authors: Balion, Cynthia M , Santaguida, Pasqualina , Mcqueen, Matthew J , Ismaila, Afisi S , Reichert, Sonja M , Mckelvie, Robert , Worster, Andrew , Raina, Parminder S
Format: Electronic Article Electronic Article
Language: English
Subjects:
Bnp
Bnp
ID: ISSN: 0009-9120 ; E-ISSN: 1873-2933 ; DOI: 10.1016/j.clinbiochem.2007.08.016
Link: http://dx.doi.org/10.1016/j.clinbiochem.2007.08.016
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recordid: elsevier_sdoi_10_1016_j_clinbiochem_2007_08_016
title: Evidence for the use of B-type natriuretic peptides for screening asymptomatic populations and for diagnosis in primary care
format: Article
creator:
  • Hill, Stephen A
  • Balion, Cynthia M
  • Santaguida, Pasqualina
  • Mcqueen, Matthew J
  • Ismaila, Afisi S
  • Reichert, Sonja M
  • Mckelvie, Robert
  • Worster, Andrew
  • Raina, Parminder S
subjects:
  • Natriuretic Peptide
  • Bnp
  • NT-Probnp
  • Diagnosis
  • Screening
  • Heart Failure
  • Systematic Review
  • Primary Care
  • Natriuretic Peptide
  • Bnp
  • NT-Probnp
  • Diagnosis
  • Screening
  • Heart Failure
  • Systematic Review
  • Primary Care
  • Medicine
  • Chemistry
ispartof: Clinical Biochemistry, 2008, Vol.41(4), pp.240-249
description: To determine the screening and diagnostic properties of BNP and NT-proBNP for heart failure in primary care. We conducted a systematic review of randomized control trials and observational (cohort or case–control) studies of heart failure detection using B-type natriuretic peptides published in English from January 1989 to February 2005. We extracted or calculated sensitivity, specificity, positive and negative likelihood ratios, area under the receiver–operator characteristic curve and diagnostic odds ratio (DOR). We included 17 studies (7 screening, 9 diagnosis in primary care or specialised clinic, 1 both). There was considerable heterogeneity within the study populations, reference standard for diagnosis, and B-type natriuretic peptide decision point. Sensitivity ranged from 26% to 98%; and specificity from 44% to 88%. For screening, the Diagnostic Odds Ratio (DOR) ranged from 2.7 to 29, and for diagnosis from 2.8 to 137. The...
language: eng
source:
identifier: ISSN: 0009-9120 ; E-ISSN: 1873-2933 ; DOI: 10.1016/j.clinbiochem.2007.08.016
fulltext: fulltext
issn:
  • 0009-9120
  • 00099120
  • 1873-2933
  • 18732933
url: Link


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titleEvidence for the use of B-type natriuretic peptides for screening asymptomatic populations and for diagnosis in primary care
creatorHill, Stephen A ; Balion, Cynthia M ; Santaguida, Pasqualina ; Mcqueen, Matthew J ; Ismaila, Afisi S ; Reichert, Sonja M ; Mckelvie, Robert ; Worster, Andrew ; Raina, Parminder S
ispartofClinical Biochemistry, 2008, Vol.41(4), pp.240-249
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subjectNatriuretic Peptide ; Bnp ; NT-Probnp ; Diagnosis ; Screening ; Heart Failure ; Systematic Review ; Primary Care ; Natriuretic Peptide ; Bnp ; NT-Probnp ; Diagnosis ; Screening ; Heart Failure ; Systematic Review ; Primary Care ; Medicine ; Chemistry
descriptionTo determine the screening and diagnostic properties of BNP and NT-proBNP for heart failure in primary care. We conducted a systematic review of randomized control trials and observational (cohort or case–control) studies of heart failure detection using B-type natriuretic peptides published in English from January 1989 to February 2005. We extracted or calculated sensitivity, specificity, positive and negative likelihood ratios, area under the receiver–operator characteristic curve and diagnostic odds ratio (DOR). We included 17 studies (7 screening, 9 diagnosis in primary care or specialised clinic, 1 both). There was considerable heterogeneity within the study populations, reference standard for diagnosis, and B-type natriuretic peptide decision point. Sensitivity ranged from 26% to 98%; and specificity from 44% to 88%. For screening, the Diagnostic Odds Ratio (DOR) ranged from 2.7 to 29, and for diagnosis from 2.8 to 137. The...
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titleEvidence for the use of B-type natriuretic peptides for screening asymptomatic populations and for diagnosis in primary care
authorHill, Stephen A ; Balion, Cynthia M ; Santaguida, Pasqualina ; Mcqueen, Matthew J ; Ismaila, Afisi S ; Reichert, Sonja M ; Mckelvie, Robert ; Worster, Andrew ; Raina, Parminder S
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