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Thermodynamic and structural characterization of Liposomal-Locked in-Dendrimers as drug carriers

A new Liposomal-Locked in-Dendrimer (LLD) formed by DPPC–DPPG and PAMAM 3.5 incorporating the anticancer drug DOX was studied by means of spectroscopic and DSC investigations. Multilamellar Lipid Bilayers were also considered for the sake of comparison. The results were in line with a picture of pha... Full description

Journal Title: Colloids and Surfaces B: Biointerfaces 2010, Vol.81(1), pp.11-19
Main Author: Gardikis, Konstantinos
Other Authors: Hatziantoniou, Sophia , Signorelli, Marco , Pusceddu, Marianna , Micha-Screttas, Maria , Schiraldi, Alberto , Demetzos, Costas , Fessas, Dimitrios
Format: Electronic Article Electronic Article
Language: English
Subjects:
Dox
LLD
Dsc
ID: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2010.06.010
Link: https://www.sciencedirect.com/science/article/pii/S0927776510003279
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recordid: elsevier_sdoi_10_1016_j_colsurfb_2010_06_010
title: Thermodynamic and structural characterization of Liposomal-Locked in-Dendrimers as drug carriers
format: Article
creator:
  • Gardikis, Konstantinos
  • Hatziantoniou, Sophia
  • Signorelli, Marco
  • Pusceddu, Marianna
  • Micha-Screttas, Maria
  • Schiraldi, Alberto
  • Demetzos, Costas
  • Fessas, Dimitrios
subjects:
  • Liposomes
  • Dendrimers
  • Dox
  • LLD
  • Drug Carrier
  • Dsc
  • Engineering
  • Chemistry
  • Anatomy & Physiology
ispartof: Colloids and Surfaces B: Biointerfaces, 2010, Vol.81(1), pp.11-19
description: A new Liposomal-Locked in-Dendrimer (LLD) formed by DPPC–DPPG and PAMAM 3.5 incorporating the anticancer drug DOX was studied by means of spectroscopic and DSC investigations. Multilamellar Lipid Bilayers were also considered for the sake of comparison. The results were in line with a picture of phase separation between DPPC–DPPG lipids and dendrimer that promotes the stability of the liposome membrane and the cooperativity of the relevant gel-to-liquid-crystal transition, which is enhanced in the presence of the dendrimer and the drug. As a result, the inner core of the liposome contained large amounts of dendrimer–DOX complex and was protected by a very stable membrane. This view was given a more general validation through investigations performed with other types of dendrimers, namely PG1 and PG2. The thermodynamic interpretation of the DSC data allowed a better understanding of the physico-chemical factors that justify this behaviour that makes these LLDs very promising as a new class of Modulatory Liposomal Controlled Release System (MLCRS) that could lead to drug formulations with higher safety and efficacy profiles.
language: eng
source:
identifier: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2010.06.010
fulltext: fulltext
issn:
  • 0927-7765
  • 09277765
  • 1873-4367
  • 18734367
url: Link


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titleThermodynamic and structural characterization of Liposomal-Locked in-Dendrimers as drug carriers
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descriptionA new Liposomal-Locked in-Dendrimer (LLD) formed by DPPC–DPPG and PAMAM 3.5 incorporating the anticancer drug DOX was studied by means of spectroscopic and DSC investigations. Multilamellar Lipid Bilayers were also considered for the sake of comparison. The results were in line with a picture of phase separation between DPPC–DPPG lipids and dendrimer that promotes the stability of the liposome membrane and the cooperativity of the relevant gel-to-liquid-crystal transition, which is enhanced in the presence of the dendrimer and the drug. As a result, the inner core of the liposome contained large amounts of dendrimer–DOX complex and was protected by a very stable membrane. This view was given a more general validation through investigations performed with other types of dendrimers, namely PG1 and PG2. The thermodynamic interpretation of the DSC data allowed a better understanding of the physico-chemical factors that justify this behaviour that makes these LLDs very promising as a new class of Modulatory Liposomal Controlled Release System (MLCRS) that could lead to drug formulations with higher safety and efficacy profiles.
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A new Liposomal-Locked in-Dendrimer (LLD) formed by DPPC–DPPG and PAMAM 3.5 incorporating the anticancer drug DOX was studied by means of spectroscopic and DSC investigations. Multilamellar Lipid Bilayers were also considered for the sake of comparison. The results were in line with a picture of phase separation between DPPC–DPPG lipids and dendrimer that promotes the stability of the liposome membrane and the cooperativity of the relevant gel-to-liquid-crystal transition, which is enhanced in the presence of the dendrimer and the drug. As a result, the inner core of the liposome contained large amounts of dendrimer–DOX complex and was protected by a very stable membrane. This view was given a more general validation through investigations performed with other types of dendrimers, namely PG1 and PG2. The thermodynamic interpretation of the DSC data allowed a better understanding of the physico-chemical factors that justify this behaviour that makes these LLDs very promising as a new class of Modulatory Liposomal Controlled Release System (MLCRS) that could lead to drug formulations with higher safety and efficacy profiles.

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A new Liposomal-Locked in-Dendrimer (LLD) formed by DPPC–DPPG and PAMAM 3.5 incorporating the anticancer drug DOX was studied by means of spectroscopic and DSC investigations. Multilamellar Lipid Bilayers were also considered for the sake of comparison. The results were in line with a picture of phase separation between DPPC–DPPG lipids and dendrimer that promotes the stability of the liposome membrane and the cooperativity of the relevant gel-to-liquid-crystal transition, which is enhanced in the presence of the dendrimer and the drug. As a result, the inner core of the liposome contained large amounts of dendrimer–DOX complex and was protected by a very stable membrane. This view was given a more general validation through investigations performed with other types of dendrimers, namely PG1 and PG2. The thermodynamic interpretation of the DSC data allowed a better understanding of the physico-chemical factors that justify this behaviour that makes these LLDs very promising as a new class of Modulatory Liposomal Controlled Release System (MLCRS) that could lead to drug formulations with higher safety and efficacy profiles.

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doi10.1016/j.colsurfb.2010.06.010
lad01Colloids and Surfaces B: Biointerfaces
date2010-11-01