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Ellagic acid encapsulated chitosan nanoparticles for drug delivery system in human oral cancer cell line (KB)

•Ellagic acid encapsulated chitosan nanoparticles were successfully synthesized by ionic gelation method.•Physicochemical characterization confirms the synthesis of nanoparticles.•In vitro dug release profile showed sustained release of ellagic acid.•Nanoformulated ellagic acid exhibited enhanced cy... Full description

Journal Title: Colloids and Surfaces B: Biointerfaces 01 October 2013, Vol.110, pp.313-320
Main Author: Arulmozhi, V
Other Authors: Pandian, K , Mirunalini, S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2013.03.039
Link: http://dx.doi.org/10.1016/j.colsurfb.2013.03.039
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recordid: elsevier_sdoi_10_1016_j_colsurfb_2013_03_039
title: Ellagic acid encapsulated chitosan nanoparticles for drug delivery system in human oral cancer cell line (KB)
format: Article
creator:
  • Arulmozhi, V
  • Pandian, K
  • Mirunalini, S
subjects:
  • Ellagic Acid
  • Chitosan Nanoparticles
  • Encapsulation
  • In Vitro Studies
  • Anticancer Activity
  • Human Kb Cell Line
  • Ellagic Acid
  • Chitosan Nanoparticles
  • Encapsulation
  • In Vitro Studies
  • Anticancer Activity
  • Human Kb Cell Line
  • Engineering
  • Chemistry
  • Anatomy & Physiology
ispartof: Colloids and Surfaces B: Biointerfaces, 01 October 2013, Vol.110, pp.313-320
description: •Ellagic acid encapsulated chitosan nanoparticles were successfully synthesized by ionic gelation method.•Physicochemical characterization confirms the synthesis of nanoparticles.•In vitro dug release profile showed sustained release of ellagic acid.•Nanoformulated ellagic acid exhibited enhanced cytotoxicity in KB cells. Ellagic acid (EA), a naturally occurring polyphenolic compound is well documented for its anticancer property in numerous pre-clinical models. The properties like poor water solubility and limited oral bio-availability of ellagic acid has hampered its clinical applications. The present study, reports the preparation of ellagic acid encapsulated chitosan nanoparticles (EA@CS-NP) by ionic gelation method as an effective drug delivery for oral cancer treatment. The synthesized ellagic acid nanoparticle is spherical shaped with an average particle size of 176nm. The drug-encapsulation and loading-efficiency of the nanoparticles...
language: eng
source:
identifier: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2013.03.039
fulltext: fulltext
issn:
  • 0927-7765
  • 09277765
  • 1873-4367
  • 18734367
url: Link


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subjectEllagic Acid ; Chitosan Nanoparticles ; Encapsulation ; In Vitro Studies ; Anticancer Activity ; Human Kb Cell Line ; Ellagic Acid ; Chitosan Nanoparticles ; Encapsulation ; In Vitro Studies ; Anticancer Activity ; Human Kb Cell Line ; Engineering ; Chemistry ; Anatomy & Physiology
description•Ellagic acid encapsulated chitosan nanoparticles were successfully synthesized by ionic gelation method.•Physicochemical characterization confirms the synthesis of nanoparticles.•In vitro dug release profile showed sustained release of ellagic acid.•Nanoformulated ellagic acid exhibited enhanced cytotoxicity in KB cells. Ellagic acid (EA), a naturally occurring polyphenolic compound is well documented for its anticancer property in numerous pre-clinical models. The properties like poor water solubility and limited oral bio-availability of ellagic acid has hampered its clinical applications. The present study, reports the preparation of ellagic acid encapsulated chitosan nanoparticles (EA@CS-NP) by ionic gelation method as an effective drug delivery for oral cancer treatment. The synthesized ellagic acid nanoparticle is spherical shaped with an average particle size of 176nm. The drug-encapsulation and loading-efficiency of the nanoparticles...
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•Ellagic acid encapsulated chitosan nanoparticles were successfully synthesized by ionic gelation method.•Physicochemical characterization confirms the synthesis of nanoparticles.•In vitro dug release profile showed sustained release of ellagic acid.•Nanoformulated ellagic acid exhibited enhanced cytotoxicity in KB cells.

Ellagic acid (EA), a naturally occurring polyphenolic compound is well documented for its anticancer property in numerous pre-clinical models. The properties like poor water solubility and limited oral bio-availability of ellagic acid has hampered its clinical applications. The present study, reports the preparation of ellagic acid encapsulated chitosan nanoparticles (EA@CS-NP) by ionic gelation method as an effective drug delivery for oral cancer treatment. The synthesized ellagic acid nanoparticle is spherical shaped with an average particle size of 176nm. The drug-encapsulation and loading-efficiency of the nanoparticles...

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•Ellagic acid encapsulated chitosan nanoparticles were successfully synthesized by ionic gelation method.•Physicochemical characterization confirms the synthesis of nanoparticles.•In vitro dug release profile showed sustained release of ellagic acid.•Nanoformulated ellagic acid exhibited enhanced cytotoxicity in KB cells.

Ellagic acid (EA), a naturally occurring polyphenolic compound is well documented for its anticancer property in numerous pre-clinical models. The properties like poor water solubility and limited oral bio-availability of ellagic acid has hampered its clinical applications. The present study, reports the preparation of ellagic acid encapsulated chitosan nanoparticles (EA@CS-NP) by ionic gelation method as an effective drug delivery for oral cancer treatment. The synthesized ellagic acid nanoparticle is spherical shaped with an average particle size of 176nm. The drug-encapsulation and loading-efficiency of the nanoparticles...

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lad01Colloids and Surfaces B: Biointerfaces
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