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Highly uniform and stable cerasomal microcapsule with good biocompatibility for drug delivery

A biocompatible cerasomal microcapsule with high colloidal stability and uniform size was successfully developed to encapsulate anticancer drug doxorubicin at high drug loading content. Efforts to improve the stability of liposomes have recently led to the development of organic–inorganic liposomal... Full description

Journal Title: Colloids and Surfaces B: Biointerfaces 01 April 2014, Vol.116, pp.327-333
Main Author: Zhang, Chun-Yang
Other Authors: Cao, Zhong , Zhu, Wen-Jian , Liu, Jie , Jiang, Qing , Shuai, Xin-Tao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2014.01.013
Link: https://www.sciencedirect.com/science/article/pii/S0927776514000149
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recordid: elsevier_sdoi_10_1016_j_colsurfb_2014_01_013
title: Highly uniform and stable cerasomal microcapsule with good biocompatibility for drug delivery
format: Article
creator:
  • Zhang, Chun-Yang
  • Cao, Zhong
  • Zhu, Wen-Jian
  • Liu, Jie
  • Jiang, Qing
  • Shuai, Xin-Tao
subjects:
  • Microcapsule
  • Drug Delivery
  • Liposomes
  • Stability
  • Uniform Size
  • Engineering
  • Chemistry
  • Anatomy & Physiology
ispartof: Colloids and Surfaces B: Biointerfaces, 01 April 2014, Vol.116, pp.327-333
description: A biocompatible cerasomal microcapsule with high colloidal stability and uniform size was successfully developed to encapsulate anticancer drug doxorubicin at high drug loading content. Efforts to improve the stability of liposomes have recently led to the development of organic–inorganic liposomal cerasomes. However, the uncontrollable size of cerasomes has greatly limited their biomedical applications. In this study, a novel strategy was introduced to fabricate hybrid liposomal cerasomes with high stability and uniform size. The hybrid lipids were first deposited onto CaCO microspheres through electrostatic interactions and self-assembly, and then the CaCO core was removed to obtain hollow microcapsules, i.e. the cerasomes. The species of the lipid oligomers was detected by MALDI-TOF-MS, which demonstrates the existence of siloxane network on microcapsules’ surface. Anticancer drug doxorubicin hydrochloride (DOX) loaded cerasomal microcapsule (DLCM) exhibited an initial burst release behavior followed by the sustained release and remarkably high stability towards surfactant solubilization and long term storage. The DLCM displayed a pH-dependent and sustained DOX release profile in vitro, which can be well explained using a well established mathematical model. Our results indicate that these novel cerasomal microcapsules have great potential to be applied as drug delivery system in cancer therapy.
language: eng
source:
identifier: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2014.01.013
fulltext: fulltext
issn:
  • 0927-7765
  • 09277765
  • 1873-4367
  • 18734367
url: Link


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descriptionA biocompatible cerasomal microcapsule with high colloidal stability and uniform size was successfully developed to encapsulate anticancer drug doxorubicin at high drug loading content. Efforts to improve the stability of liposomes have recently led to the development of organic–inorganic liposomal cerasomes. However, the uncontrollable size of cerasomes has greatly limited their biomedical applications. In this study, a novel strategy was introduced to fabricate hybrid liposomal cerasomes with high stability and uniform size. The hybrid lipids were first deposited onto CaCO microspheres through electrostatic interactions and self-assembly, and then the CaCO core was removed to obtain hollow microcapsules, i.e. the cerasomes. The species of the lipid oligomers was detected by MALDI-TOF-MS, which demonstrates the existence of siloxane network on microcapsules’ surface. Anticancer drug doxorubicin hydrochloride (DOX) loaded cerasomal microcapsule (DLCM) exhibited an initial burst release behavior followed by the sustained release and remarkably high stability towards surfactant solubilization and long term storage. The DLCM displayed a pH-dependent and sustained DOX release profile in vitro, which can be well explained using a well established mathematical model. Our results indicate that these novel cerasomal microcapsules have great potential to be applied as drug delivery system in cancer therapy.
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