schliessen

Filtern

 

Bibliotheken

Insertion of pH-sensitive bola-type copolymer into liposome as a “stability anchor” for control of drug release

How to design intelligent carriers for delivering drugs to the target accurately and releasing drug timely with the help of a certain environmental stimulus is still a challenge in tumor treatment. In this work, pH-sensitive bola-type triblock copolymers, composed of poly(2-(diisopropylamino) ethylm... Full description

Journal Title: Colloids and Surfaces B: Biointerfaces 01 December 2015, Vol.136, pp.809-816
Main Author: Hao, Weiju
Other Authors: Han, Xia , Shang, Yazhuo , Xu, Shouhong , Liu, Honglai
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2015.10.033
Link: https://www.sciencedirect.com/science/article/pii/S0927776515302642
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_colsurfb_2015_10_033
title: Insertion of pH-sensitive bola-type copolymer into liposome as a “stability anchor” for control of drug release
format: Article
creator:
  • Hao, Weiju
  • Han, Xia
  • Shang, Yazhuo
  • Xu, Shouhong
  • Liu, Honglai
subjects:
  • Bola-Type Copolymer
  • Ph-Sensitivity
  • Liposome
  • Drug Release
  • Engineering
  • Chemistry
  • Anatomy & Physiology
ispartof: Colloids and Surfaces B: Biointerfaces, 01 December 2015, Vol.136, pp.809-816
description: How to design intelligent carriers for delivering drugs to the target accurately and releasing drug timely with the help of a certain environmental stimulus is still a challenge in tumor treatment. In this work, pH-sensitive bola-type triblock copolymers, composed of poly(2-(diisopropylamino) ethylmethacrylate) (PDPA) and methoxy-poly(ethyleneglycol) (mPEG), were synthesized. Liposomes containing these copolymers (Liposome@Bola) have been prepared by simply mixing the copolymer with phospholipids and cholesterol. From the fluorescence polarization measurement, the stability of Liposome@Bola was found to be increased a lot comparing to the pure liposome. As a result, the doxorubicin (DOX) leakage of the former was restrained in neutral environment. However, when pH decreased from 7.4 to 6.0, DOX released percentage had been increased 30–60 points, which was heavily depend on the phospholipid composition. Furthermore, the size effects of PEG and PDPA segments were also investigated. These results indicated the synthesized bola-type copolymers improved the pH-controllability of drug release of liposome, i.e., increased the difference between the release amount under pH 7.4 and pH 6.0. The bola-type copolymer exhibited a good potential application in smartly controlling drug delivery system.
language: eng
source:
identifier: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2015.10.033
fulltext: fulltext
issn:
  • 0927-7765
  • 09277765
  • 1873-4367
  • 18734367
url: Link


@attributes
ID78403685
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_colsurfb_2015_10_033
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_colsurfb_2015_10_033
sourcesystemOther
dbid
0--K
1--M
2.~1
31B1
41~.
5457
64G.
77-5
88P~
99JM
109JN
11AAEDT
12AAEPC
13AAKOC
14AAOAW
15AAQFI
16AARLI
17ABGSF
18ABNUV
19ABXRA
20ABYKQ
21ACDAQ
22ACFVG
23ACRLP
24ADECG
25ADEWK
26ADUVX
27AEHWI
28AEKER
29AEZYN
30AFKWA
31AFTJW
32AFXIZ
33AGHFR
34AGUBO
35AGYEJ
36AHPOS
37AIKHN
38AITUG
39AIVDX
40AJBFU
41AJOXV
42AJSZI
43AMFUW
44BLXMC
45DOVZS
46ENUVR
47EO8
48EO9
49EP2
50EP3
51FDB
52FIRID
53FLBIZ
54FNPLU
55G-Q
56GBLVA
57J1W
58KOM
59MAGPM
60OAUVE
61OGIMB
62P-8
63P-9
64PC.
65Q38
66RPZ
67SDF
68SDG
69SDP
70SES
71SPC
72SSG
73SSK
74SSM
75SSQ
76SSU
77SSZ
78T5K
79~G-
pqid1778027925
galeid520299379
display
typearticle
titleInsertion of pH-sensitive bola-type copolymer into liposome as a “stability anchor” for control of drug release
creatorHao, Weiju ; Han, Xia ; Shang, Yazhuo ; Xu, Shouhong ; Liu, Honglai
ispartofColloids and Surfaces B: Biointerfaces, 01 December 2015, Vol.136, pp.809-816
identifier
subjectBola-Type Copolymer ; Ph-Sensitivity ; Liposome ; Drug Release ; Engineering ; Chemistry ; Anatomy & Physiology
descriptionHow to design intelligent carriers for delivering drugs to the target accurately and releasing drug timely with the help of a certain environmental stimulus is still a challenge in tumor treatment. In this work, pH-sensitive bola-type triblock copolymers, composed of poly(2-(diisopropylamino) ethylmethacrylate) (PDPA) and methoxy-poly(ethyleneglycol) (mPEG), were synthesized. Liposomes containing these copolymers (Liposome@Bola) have been prepared by simply mixing the copolymer with phospholipids and cholesterol. From the fluorescence polarization measurement, the stability of Liposome@Bola was found to be increased a lot comparing to the pure liposome. As a result, the doxorubicin (DOX) leakage of the former was restrained in neutral environment. However, when pH decreased from 7.4 to 6.0, DOX released percentage had been increased 30–60 points, which was heavily depend on the phospholipid composition. Furthermore, the size effects of PEG and PDPA segments were also investigated. These results indicated the synthesized bola-type copolymers improved the pH-controllability of drug release of liposome, i.e., increased the difference between the release amount under pH 7.4 and pH 6.0. The bola-type copolymer exhibited a good potential application in smartly controlling drug delivery system.
languageeng
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttps://www.sciencedirect.com/science/article/pii/S0927776515302642$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
search
creatorcontrib
0Hao, Weiju
1Han, Xia
2Shang, Yazhuo
3Xu, Shouhong
4Liu, Honglai
titleInsertion of pH-sensitive bola-type copolymer into liposome as a “stability anchor” for control of drug release
description

How to design intelligent carriers for delivering drugs to the target accurately and releasing drug timely with the help of a certain environmental stimulus is still a challenge in tumor treatment. In this work, pH-sensitive bola-type triblock copolymers, composed of poly(2-(diisopropylamino) ethylmethacrylate) (PDPA) and methoxy-poly(ethyleneglycol) (mPEG), were synthesized. Liposomes containing these copolymers (Liposome@Bola) have been prepared by simply mixing the copolymer with phospholipids and cholesterol. From the fluorescence polarization measurement, the stability of Liposome@Bola was found to be increased a lot comparing to the pure liposome. As a result, the doxorubicin (DOX) leakage of the former was restrained in neutral environment. However, when pH decreased from 7.4 to 6.0, DOX released percentage had been increased 30–60 points, which was heavily depend on the phospholipid composition. Furthermore, the size effects of PEG and PDPA segments were also investigated. These results indicated the synthesized bola-type copolymers improved the pH-controllability of drug release of liposome, i.e., increased the difference between the release amount under pH 7.4 and pH 6.0. The bola-type copolymer exhibited a good potential application in smartly controlling drug delivery system.

subject
0Bola-Type Copolymer
1Ph-Sensitivity
2Liposome
3Drug Release
4Engineering
5Chemistry
6Anatomy & Physiology
general
0English
1Elsevier B.V
210.1016/j.colsurfb.2015.10.033
3ScienceDirect (Elsevier B.V.)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_colsurfb_2015_10_033
issn
00927-7765
109277765
21873-4367
318734367
rsrctypearticle
creationdate2015
addtitleColloids and Surfaces B: Biointerfaces
searchscope
0elsevier_full
1elsevier2
scope
0elsevier_full
1elsevier2
lsr44$$EView_record_in_ScienceDirect_(Access_to_full_text_may_be_restricted)
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
1--M
2.~1
31B1
41~.
5457
64G.
77-5
88P~
99JM
109JN
11AAEDT
12AAEPC
13AAKOC
14AAOAW
15AAQFI
16AARLI
17ABGSF
18ABNUV
19ABXRA
20ABYKQ
21ACDAQ
22ACFVG
23ACRLP
24ADECG
25ADEWK
26ADUVX
27AEHWI
28AEKER
29AEZYN
30AFKWA
31AFTJW
32AFXIZ
33AGHFR
34AGUBO
35AGYEJ
36AHPOS
37AIKHN
38AITUG
39AIVDX
40AJBFU
41AJOXV
42AJSZI
43AMFUW
44BLXMC
45DOVZS
46ENUVR
47EO8
48EO9
49EP2
50EP3
51FDB
52FIRID
53FLBIZ
54FNPLU
55G-Q
56GBLVA
57J1W
58KOM
59MAGPM
60OAUVE
61OGIMB
62P-8
63P-9
64PC.
65Q38
66RPZ
67SDF
68SDG
69SDP
70SES
71SPC
72SSG
73SSK
74SSM
75SSQ
76SSU
77SSZ
78T5K
79~G-
startdate20151201
enddate20151201
lsr40Colloids and Surfaces B: Biointerfaces, 01 December 2015, Vol.136, pp.809-816
doi10.1016/j.colsurfb.2015.10.033
citationpf 809 pt 816 vol 136
lsr30VSR-Enriched:[galeid, orcidid, pqid]
sort
titleInsertion of pH-sensitive bola-type copolymer into liposome as a “stability anchor” for control of drug release
authorHao, Weiju ; Han, Xia ; Shang, Yazhuo ; Xu, Shouhong ; Liu, Honglai
creationdate20151201
lso0120151201
facets
frbrgroupid6561504195523300532
frbrtype5
newrecords20190904
languageeng
topic
0Bola-Type Copolymer
1Ph-Sensitivity
2Liposome
3Drug Release
4Engineering
5Chemistry
6Anatomy & Physiology
collectionScienceDirect (Elsevier B.V.)
prefilterarticles
rsrctypearticles
creatorcontrib
0Hao, Weiju
1Han, Xia
2Shang, Yazhuo
3Xu, Shouhong
4Liu, Honglai
jtitleColloids and Surfaces B: Biointerfaces
creationdate2015
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Hao
1Han
2Shang
3Xu
4Liu
aufirst
0Weiju
1Xia
2Yazhuo
3Shouhong
4Honglai
auinitW
auinit1W
au
0Hao, Weiju
1Han, Xia
2Shang, Yazhuo
3Xu, Shouhong
4Liu, Honglai
atitleInsertion of pH-sensitive bola-type copolymer into liposome as a “stability anchor” for control of drug release
jtitleColloids and Surfaces B: Biointerfaces
risdate20151201
volume136
spage809
epage816
pages809-816
issn0927-7765
eissn1873-4367
formatjournal
genrearticle
ristypeJOUR
abstract

How to design intelligent carriers for delivering drugs to the target accurately and releasing drug timely with the help of a certain environmental stimulus is still a challenge in tumor treatment. In this work, pH-sensitive bola-type triblock copolymers, composed of poly(2-(diisopropylamino) ethylmethacrylate) (PDPA) and methoxy-poly(ethyleneglycol) (mPEG), were synthesized. Liposomes containing these copolymers (Liposome@Bola) have been prepared by simply mixing the copolymer with phospholipids and cholesterol. From the fluorescence polarization measurement, the stability of Liposome@Bola was found to be increased a lot comparing to the pure liposome. As a result, the doxorubicin (DOX) leakage of the former was restrained in neutral environment. However, when pH decreased from 7.4 to 6.0, DOX released percentage had been increased 30–60 points, which was heavily depend on the phospholipid composition. Furthermore, the size effects of PEG and PDPA segments were also investigated. These results indicated the synthesized bola-type copolymers improved the pH-controllability of drug release of liposome, i.e., increased the difference between the release amount under pH 7.4 and pH 6.0. The bola-type copolymer exhibited a good potential application in smartly controlling drug delivery system.

pubElsevier B.V
doi10.1016/j.colsurfb.2015.10.033
lad01Colloids and Surfaces B: Biointerfaces
orcidid0000-0002-6019-0585
date2015-12-01