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Doxorubicin-loaded photosensitive magnetic liposomes for multi-modal cancer therapy

Multifunctional magnetic nanosystems have attracted an enormous attention of researchers for their potential applications in cancer diagnostics and therapy. The localized nanotherapies triggered by the external stimuli, like magnetic fields and visible light, are significant in clinical applications... Full description

Journal Title: Colloids and Surfaces B: Biointerfaces 01 December 2016, Vol.148, pp.157-164
Main Author: Shah, Saqlain A
Other Authors: Aslam Khan, M.U , Arshad, M , Awan, S.U , Hashmi, M.U , Ahmad, N
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2016.08.055
Link: https://www.sciencedirect.com/science/article/pii/S0927776516306324
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recordid: elsevier_sdoi_10_1016_j_colsurfb_2016_08_055
title: Doxorubicin-loaded photosensitive magnetic liposomes for multi-modal cancer therapy
format: Article
creator:
  • Shah, Saqlain A
  • Aslam Khan, M.U
  • Arshad, M
  • Awan, S.U
  • Hashmi, M.U
  • Ahmad, N
subjects:
  • Magnetic Hyperthermia
  • Superparamagnetic
  • Liposomes
  • Doxorubicin
  • Hela Cells
  • Mtt Assay
  • Proteome Analysis
  • Engineering
  • Chemistry
  • Anatomy & Physiology
ispartof: Colloids and Surfaces B: Biointerfaces, 01 December 2016, Vol.148, pp.157-164
description: Multifunctional magnetic nanosystems have attracted an enormous attention of researchers for their potential applications in cancer diagnostics and therapy. The localized nanotherapies triggered by the external stimuli, like magnetic fields and visible light, are significant in clinical applications. We report a liposomal system that aims to treat cancer by magnetic hyperthermia, photodynamic therapy and chemotherapy simultaneously. The liposomes enclose clinically used photosensitizer m-THPC (Foscan) and anti-cancer drug doxorubicin, in its hydrophobic lipid bilayers, and contains magnetite nanoparticles in hydrophilic core. Three different sizes of magnetic nanoparticles (10, 22 and 30 nm) and liposomes (40, 70 and 110 nm) were used in this study. Magnetite single domain nanoparticles forming the magnetic core were superparamagnetic but liposomes expressed slight coercivity and hysteresis due to the clustering of nanoparticles in the core. This enhanced the heating efficiency (specific power loss) of the liposomes under an AC field (375 kHz, 170 Oe). Cell viability and toxicity were studied on HeLa cells using MTT assay and proteomic analysis. Confocal and fluorescence microscopy were used to study the photosensitizer’s profile and cells response to combined therapy. It revealed that combined therapy almost completely eliminated the cancer cells as opposed to the separate treatments. Magnetic hyperthermia and photodynamic therapies were almost equally effective whereas chemotherapy showed the least effect.
language: eng
source:
identifier: ISSN: 0927-7765 ; E-ISSN: 1873-4367 ; DOI: 10.1016/j.colsurfb.2016.08.055
fulltext: fulltext
issn:
  • 0927-7765
  • 09277765
  • 1873-4367
  • 18734367
url: Link


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subjectMagnetic Hyperthermia ; Superparamagnetic ; Liposomes ; Doxorubicin ; Hela Cells ; Mtt Assay ; Proteome Analysis ; Engineering ; Chemistry ; Anatomy & Physiology
descriptionMultifunctional magnetic nanosystems have attracted an enormous attention of researchers for their potential applications in cancer diagnostics and therapy. The localized nanotherapies triggered by the external stimuli, like magnetic fields and visible light, are significant in clinical applications. We report a liposomal system that aims to treat cancer by magnetic hyperthermia, photodynamic therapy and chemotherapy simultaneously. The liposomes enclose clinically used photosensitizer m-THPC (Foscan) and anti-cancer drug doxorubicin, in its hydrophobic lipid bilayers, and contains magnetite nanoparticles in hydrophilic core. Three different sizes of magnetic nanoparticles (10, 22 and 30 nm) and liposomes (40, 70 and 110 nm) were used in this study. Magnetite single domain nanoparticles forming the magnetic core were superparamagnetic but liposomes expressed slight coercivity and hysteresis due to the clustering of nanoparticles in the core. This enhanced the heating efficiency (specific power loss) of the liposomes under an AC field (375 kHz, 170 Oe). Cell viability and toxicity were studied on HeLa cells using MTT assay and proteomic analysis. Confocal and fluorescence microscopy were used to study the photosensitizer’s profile and cells response to combined therapy. It revealed that combined therapy almost completely eliminated the cancer cells as opposed to the separate treatments. Magnetic hyperthermia and photodynamic therapies were almost equally effective whereas chemotherapy showed the least effect.
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