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Safety and efficacy in parous women of a 52-mg levonorgestrel-medicated intrauterine device: a 7-year randomized comparative study with the TCu380A

To compare rates of unintended pregnancy, method continuation and reasons for removal among women using the 52-mg levonorgestrel (daily release 20 microg) levonorgestrel IUD (LNG-IUD) or the copper T 380A (TCu380A) intrauterine device. This was an open-label 7-year randomized controlled trial in 20... Full description

Journal Title: Contraception June 2016, Vol.93(6), pp.498-506
Main Author: Rowe, Patrick
Other Authors: Farley, Tim , Peregoudov, Alexandre , Piaggio, Gilda , Boccard, Simone , Landoulsi, Sihem , Meirik, Olav
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0010-7824 ; E-ISSN: 1879-0518 ; DOI: 10.1016/j.contraception.2016.02.024
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recordid: elsevier_sdoi_10_1016_j_contraception_2016_02_024
title: Safety and efficacy in parous women of a 52-mg levonorgestrel-medicated intrauterine device: a 7-year randomized comparative study with the TCu380A
format: Article
creator:
  • Rowe, Patrick
  • Farley, Tim
  • Peregoudov, Alexandre
  • Piaggio, Gilda
  • Boccard, Simone
  • Landoulsi, Sihem
  • Meirik, Olav
subjects:
  • Levonorgestrel IUD
  • Mirena®
  • Tcu380a
  • Paragard®
  • Randomized Trial
  • Seven Years
  • Levonorgestrel IUD
  • Mirena®
  • Tcu380a
  • Paragard®
  • Randomized Trial
  • Seven Years
  • Medicine
ispartof: Contraception, June 2016, Vol.93(6), pp.498-506
description: To compare rates of unintended pregnancy, method continuation and reasons for removal among women using the 52-mg levonorgestrel (daily release 20 microg) levonorgestrel IUD (LNG-IUD) or the copper T 380A (TCu380A) intrauterine device. This was an open-label 7-year randomized controlled trial in 20 centres, 11 of which in China. Data on 1884 women with interval insertion of the LNG-IUD and 1871 of the TCu380A were analysed using life tables with 30-day intervals and Cox proportional hazards models. The cumulative 7-year pregnancy rate of the LNG-IUD was 0.5 (standard error 0.2) per 100, significantly lower than 2.5 (0.4) per 100 of the TCu380A, cumulative method discontinuation rates at 7 years were 70.6 (1.2) and 40.8 (1.3) per 100, respectively. Dominant reasons for discontinuing the LNG-IUD were amenorrhea (26.1 [1.3] per 100) and reduced bleeding (12.5 [1.1] per 100), particularly in Chinese women and, for the TCu380A, increased bleeding...
language: eng
source:
identifier: ISSN: 0010-7824 ; E-ISSN: 1879-0518 ; DOI: 10.1016/j.contraception.2016.02.024
fulltext: fulltext
issn:
  • 0010-7824
  • 00107824
  • 1879-0518
  • 18790518
url: Link


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titleSafety and efficacy in parous women of a 52-mg levonorgestrel-medicated intrauterine device: a 7-year randomized comparative study with the TCu380A
creatorRowe, Patrick ; Farley, Tim ; Peregoudov, Alexandre ; Piaggio, Gilda ; Boccard, Simone ; Landoulsi, Sihem ; Meirik, Olav
contributorfor the IUD Research Group of the UNDP/UNFPA/WHO/World Bank Special Programme of Research; Development and Research Training in Human Reproduction (Corporate Author)
ispartofContraception, June 2016, Vol.93(6), pp.498-506
identifier
subjectLevonorgestrel IUD ; Mirena® ; Tcu380a ; Paragard® ; Randomized Trial ; Seven Years ; Levonorgestrel IUD ; Mirena® ; Tcu380a ; Paragard® ; Randomized Trial ; Seven Years ; Medicine
descriptionTo compare rates of unintended pregnancy, method continuation and reasons for removal among women using the 52-mg levonorgestrel (daily release 20 microg) levonorgestrel IUD (LNG-IUD) or the copper T 380A (TCu380A) intrauterine device. This was an open-label 7-year randomized controlled trial in 20 centres, 11 of which in China. Data on 1884 women with interval insertion of the LNG-IUD and 1871 of the TCu380A were analysed using life tables with 30-day intervals and Cox proportional hazards models. The cumulative 7-year pregnancy rate of the LNG-IUD was 0.5 (standard error 0.2) per 100, significantly lower than 2.5 (0.4) per 100 of the TCu380A, cumulative method discontinuation rates at 7 years were 70.6 (1.2) and 40.8 (1.3) per 100, respectively. Dominant reasons for discontinuing the LNG-IUD were amenorrhea (26.1 [1.3] per 100) and reduced bleeding (12.5 [1.1] per 100), particularly in Chinese women and, for the TCu380A, increased bleeding...
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titleSafety and efficacy in parous women of a 52-mg levonorgestrel-medicated intrauterine device: a 7-year randomized comparative study with the TCu380A
description

To compare rates of unintended pregnancy, method continuation and reasons for removal among women using the 52-mg levonorgestrel (daily release 20 microg) levonorgestrel IUD (LNG-IUD) or the copper T 380A (TCu380A) intrauterine device.

This was an open-label 7-year randomized controlled trial in 20 centres, 11 of which in China. Data on 1884 women with interval insertion of the LNG-IUD and 1871 of the TCu380A were analysed using life tables with 30-day intervals and Cox proportional hazards models.

The cumulative 7-year pregnancy rate of the LNG-IUD was 0.5 (standard error 0.2) per 100, significantly lower than 2.5 (0.4) per 100 of the TCu380A, cumulative method discontinuation rates at 7 years were 70.6 (1.2) and 40.8 (1.3) per 100, respectively. Dominant reasons for discontinuing the LNG-IUD were amenorrhea (26.1 [1.3] per 100) and reduced bleeding (12.5 [1.1] per 100), particularly in Chinese women and, for the TCu380A, increased bleeding...

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abstract

To compare rates of unintended pregnancy, method continuation and reasons for removal among women using the 52-mg levonorgestrel (daily release 20 microg) levonorgestrel IUD (LNG-IUD) or the copper T 380A (TCu380A) intrauterine device.

This was an open-label 7-year randomized controlled trial in 20 centres, 11 of which in China. Data on 1884 women with interval insertion of the LNG-IUD and 1871 of the TCu380A were analysed using life tables with 30-day intervals and Cox proportional hazards models.

The cumulative 7-year pregnancy rate of the LNG-IUD was 0.5 (standard error 0.2) per 100, significantly lower than 2.5 (0.4) per 100 of the TCu380A, cumulative method discontinuation rates at 7 years were 70.6 (1.2) and 40.8 (1.3) per 100, respectively. Dominant reasons for discontinuing the LNG-IUD were amenorrhea (26.1 [1.3] per 100) and reduced bleeding (12.5 [1.1] per 100), particularly in Chinese women and, for the TCu380A, increased bleeding...

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