schliessen

Filtern

 

Bibliotheken

Phosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion

The biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of phosphatidylinositol-3-phosphate (PtdIns3P) at the phagophore assembly site (PAS), the location where autophagosomes arise. The current model is that Ptd... Full description

Journal Title: Current Biology 11 September 2012, Vol.22(17), pp.1545-1553
Main Author: Cebollero, Eduardo
Other Authors: Van der vaart, Aniek , Zhao, Mantong , Rieter, Ester , Klionsky, Daniel j , Helms, J. bernd , Reggiori, Fulvio
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0960-9822 ; E-ISSN: 1879-0445 ; DOI: 10.1016/j.cub.2012.06.029
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: elsevier_sdoi_10_1016_j_cub_2012_06_029
title: Phosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion
format: Article
creator:
  • Cebollero, Eduardo
  • Van der vaart, Aniek
  • Zhao, Mantong
  • Rieter, Ester
  • Klionsky, Daniel j
  • Helms, J. bernd
  • Reggiori, Fulvio
subjects:
  • Biology
ispartof: Current Biology, 11 September 2012, Vol.22(17), pp.1545-1553
description: The biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of phosphatidylinositol-3-phosphate (PtdIns3P) at the phagophore assembly site (PAS), the location where autophagosomes arise. The current model is that PtdIns3P is involved primarily in the recruitment of Atg proteins to the PAS and that once an autophagosome is complete, the Atg machinery is released from its surface back into the cytoplasm and reused for the formation of new vesicles. We have identified a PtdIns3P phosphatase, Ymr1, that is essential for the normal progression of both bulk and selective types of autophagy. This protein is recruited to the PAS at an early stage of formation of this structure through a process that requires both its GRAM domain and its catalytic activity. In the absence of Ymr1, Atg proteins fail to dissociate from the limiting membrane of autophagosomes, and these vesicles accumulate...
language: eng
source:
identifier: ISSN: 0960-9822 ; E-ISSN: 1879-0445 ; DOI: 10.1016/j.cub.2012.06.029
fulltext: fulltext
issn:
  • 0960-9822
  • 09609822
  • 1879-0445
  • 18790445
url: Link


@attributes
ID664725480
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordiddoi_10_1016_j_cub_2012_06_029
sourceidelsevier_s
recordidTN_elsevier_sdoi_10_1016_j_cub_2012_06_029
sourcesystemPC
dbid
0--K
11RT
2457
34G.
46I.
57-5
6AAEDT
7AAFTH
8AAKRW
9AAQFI
10AAVLU
11AAXJY
12ABVKL
13AFTJW
14AGHFR
15AGUBO
16AITUG
17ALKID
18FDB
19FIRID
20IXB
21J1W
22JIG
23RPZ
24SCP
25SDG
26SES
27SSZ
pqid1039885255
galeid302502358
display
typearticle
titlePhosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion
creatorCebollero, Eduardo ; Van der vaart, Aniek ; Zhao, Mantong ; Rieter, Ester ; Klionsky, Daniel j ; Helms, J. bernd ; Reggiori, Fulvio
ispartofCurrent Biology, 11 September 2012, Vol.22(17), pp.1545-1553
identifier
subjectBiology
descriptionThe biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of phosphatidylinositol-3-phosphate (PtdIns3P) at the phagophore assembly site (PAS), the location where autophagosomes arise. The current model is that PtdIns3P is involved primarily in the recruitment of Atg proteins to the PAS and that once an autophagosome is complete, the Atg machinery is released from its surface back into the cytoplasm and reused for the formation of new vesicles. We have identified a PtdIns3P phosphatase, Ymr1, that is essential for the normal progression of both bulk and selective types of autophagy. This protein is recruited to the PAS at an early stage of formation of this structure through a process that requires both its GRAM domain and its catalytic activity. In the absence of Ymr1, Atg proteins fail to dissociate from the limiting membrane of autophagosomes, and these vesicles accumulate...
languageeng
oafree_for_read
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
linktorsrc$$Uhttp://dx.doi.org/10.1016/j.cub.2012.06.029$$EView_full_text_in_ScienceDirect
search
creatorcontrib
0Cebollero, Eduardo
1Van der vaart, Aniek
2Zhao, Mantong
3Rieter, Ester
4Klionsky, Daniel j
5Helms, J. bernd
6Reggiori, Fulvio
titlePhosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion
description

The biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of phosphatidylinositol-3-phosphate (PtdIns3P) at the phagophore assembly site (PAS), the location where autophagosomes arise. The current model is that PtdIns3P is involved primarily in the recruitment of Atg proteins to the PAS and that once an autophagosome is complete, the Atg machinery is released from its surface back into the cytoplasm and reused for the formation of new vesicles.

We have identified a PtdIns3P phosphatase, Ymr1, that is essential for the normal progression of both bulk and selective types of autophagy. This protein is recruited to the PAS at an early stage of formation of this structure through a process that requires both its GRAM domain and its catalytic activity. In the absence of Ymr1, Atg proteins fail to dissociate from the limiting membrane of autophagosomes, and these vesicles accumulate...

subjectBiology
general
0English
1Elsevier Inc
210.1016/j.cub.2012.06.029
3ScienceDirect (Elsevier)
4ScienceDirect Journals (Elsevier)
sourceidelsevier_s
recordidelsevier_sdoi_10_1016_j_cub_2012_06_029
issn
00960-9822
109609822
21879-0445
318790445
rsrctypearticle
creationdate2012
addtitleCurrent Biology
searchscope
0elsevier_full
1elsevier4
2elsevier2
scope
0elsevier_full
1elsevier4
2elsevier2
lsr45$$EView_full_text_in_ScienceDirect
tmp01ScienceDirect Journals (Elsevier)
tmp02
0--K
11RT
2457
34G.
46I.
57-5
6AAEDT
7AAFTH
8AAKRW
9AAQFI
10AAVLU
11AAXJY
12ABVKL
13AFTJW
14AGHFR
15AGUBO
16AITUG
17ALKID
18FDB
19FIRID
20IXB
21J1W
22JIG
23RPZ
24SCP
25SDG
26SES
27SSZ
startdate20120911
enddate20120911
lsr40Current Biology, 11 September 2012, Vol.22 (17), pp.1545-1553
doi10.1016/j.cub.2012.06.029
citationpf 1545 pt 1553 vol 22 issue 17
lsr30VSR-Enriched:[pqid, galeid]
sort
titlePhosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion
authorCebollero, Eduardo ; Van der vaart, Aniek ; Zhao, Mantong ; Rieter, Ester ; Klionsky, Daniel j ; Helms, J. bernd ; Reggiori, Fulvio
creationdate20120911
lso0120120911
facets
frbrgroupid6852504539301167324
frbrtype5
newrecords20190904
languageeng
topicBiology
collectionScienceDirect (Elsevier)
prefilterarticles
rsrctypearticles
creatorcontrib
0Cebollero, Eduardo
1Van der vaart, Aniek
2Zhao, Mantong
3Rieter, Ester
4Klionsky, Daniel j
5Helms, J. bernd
6Reggiori, Fulvio
jtitleCurrent Biology
creationdate2012
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Cebollero
1Van der vaart
2Zhao
3Rieter
4Klionsky
5Helms
6Reggiori
aufirst
0Eduardo
1Aniek
2Mantong
3Ester
4Daniel j
5J. bernd
6Fulvio
auinitE
auinit1E
au
0Cebollero, Eduardo
1Van der vaart, Aniek
2Zhao, Mantong
3Rieter, Ester
4Klionsky, Daniel j
5Helms, J. bernd
6Reggiori, Fulvio
atitlePhosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion
jtitleCurrent Biology
risdate20120911
volume22
issue17
spage1545
epage1553
pages1545-1553
issn0960-9822
eissn1879-0445
formatjournal
genrearticle
ristypeJOUR
abstract

The biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of phosphatidylinositol-3-phosphate (PtdIns3P) at the phagophore assembly site (PAS), the location where autophagosomes arise. The current model is that PtdIns3P is involved primarily in the recruitment of Atg proteins to the PAS and that once an autophagosome is complete, the Atg machinery is released from its surface back into the cytoplasm and reused for the formation of new vesicles.

We have identified a PtdIns3P phosphatase, Ymr1, that is essential for the normal progression of both bulk and selective types of autophagy. This protein is recruited to the PAS at an early stage of formation of this structure through a process that requires both its GRAM domain and its catalytic activity. In the absence of Ymr1, Atg proteins fail to dissociate from the limiting membrane of autophagosomes, and these vesicles accumulate...

pubElsevier Inc
doi10.1016/j.cub.2012.06.029
lad01Current Biology
oafree_for_read
date2012-09-11