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Structural and functional studies of MutS2 from Deinococcus radiodurans

The MutS2 homologues have been found widespread in most prokaryotes, which are involved in DNA repair and reactive oxygen species detoxification. The C-terminal small mutS-related (Smr) domain is critical for its endonucleolytic activity. However, the detailed catalytic mechanism is still unclear. I... Full description

Journal Title: DNA Repair September 2014, Vol.21, pp.111-119
Main Author: Zhang, Hui
Other Authors: Xu, Qiang , Lu, Meihua , Xu, Xin , Wang, Yunguang , Wang, Liangyan , Zhao, Ye , Hua, Yuejin
Format: Electronic Article Electronic Article
Language: English
Subjects:
Smr
ID: ISSN: 1568-7864 ; E-ISSN: 1568-7856 ; DOI: 10.1016/j.dnarep.2014.04.012
Link: https://www.sciencedirect.com/science/article/pii/S1568786414001256
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recordid: elsevier_sdoi_10_1016_j_dnarep_2014_04_012
title: Structural and functional studies of MutS2 from Deinococcus radiodurans
format: Article
creator:
  • Zhang, Hui
  • Xu, Qiang
  • Lu, Meihua
  • Xu, Xin
  • Wang, Yunguang
  • Wang, Liangyan
  • Zhao, Ye
  • Hua, Yuejin
subjects:
  • Muts2
  • Deinococcus Radiodurans
  • Oxidative Stress
  • Crystal Soaking
  • Rotamer Change
  • Metal-Binding Site
  • Smr
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: DNA Repair, September 2014, Vol.21, pp.111-119
description: The MutS2 homologues have been found widespread in most prokaryotes, which are involved in DNA repair and reactive oxygen species detoxification. The C-terminal small mutS-related (Smr) domain is critical for its endonucleolytic activity. However, the detailed catalytic mechanism is still unclear. In this study, we first investigated the role of drMutS2 in , the most radiation-resistant organism exhibits the remarkable DNA repair capacity. double knockout mutants were constructed because the phenotype was strongly masked by the predominant homologous recombination DNA repair pathway in this bacterium. Compared with the mutant, cells devoid of both genes showed increased sensitivity to ionizing radiation and oxidative agents, suggesting that drMutS2 is involved in RecA-independent mechanisms that enhance cellular resistance to oxidative stress-induced DNA damage. Moreover, the basal level of reductase...
language: eng
source:
identifier: ISSN: 1568-7864 ; E-ISSN: 1568-7856 ; DOI: 10.1016/j.dnarep.2014.04.012
fulltext: fulltext
issn:
  • 1568-7864
  • 15687864
  • 1568-7856
  • 15687856
url: Link


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creatorZhang, Hui ; Xu, Qiang ; Lu, Meihua ; Xu, Xin ; Wang, Yunguang ; Wang, Liangyan ; Zhao, Ye ; Hua, Yuejin
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subjectMuts2 ; Deinococcus Radiodurans ; Oxidative Stress ; Crystal Soaking ; Rotamer Change ; Metal-Binding Site ; Smr ; Biology ; Chemistry ; Anatomy & Physiology
descriptionThe MutS2 homologues have been found widespread in most prokaryotes, which are involved in DNA repair and reactive oxygen species detoxification. The C-terminal small mutS-related (Smr) domain is critical for its endonucleolytic activity. However, the detailed catalytic mechanism is still unclear. In this study, we first investigated the role of drMutS2 in , the most radiation-resistant organism exhibits the remarkable DNA repair capacity. double knockout mutants were constructed because the phenotype was strongly masked by the predominant homologous recombination DNA repair pathway in this bacterium. Compared with the mutant, cells devoid of both genes showed increased sensitivity to ionizing radiation and oxidative agents, suggesting that drMutS2 is involved in RecA-independent mechanisms that enhance cellular resistance to oxidative stress-induced DNA damage. Moreover, the basal level of reductase...
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